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Functional analysis of TRP receptor family on eosinophilic inflammation in mucous membrane

Research Project

Project/Area Number 16K11208
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionUniversity of Fukui

Principal Investigator

Tokunaga Takahiro  福井大学, 学術研究院医学系部門, 特別研究員 (10464075)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords好酸球性炎症 / TRPV3 / TRPV1 / アレルギー・ぜんそく
Outline of Final Research Achievements

The menthol which activates TRPV3 and the capsaicin which activates TRPV1 induce inflammatory cytokines such as RANTES, TSLP and IL-33 in nasal polyps of eosinophilic chronic rhinosinusitis. On the other hand, antagonists of TRPV3 and TRPV1 suppress the expression of these inflammatory cytokines.
Furthermore, transnasal administration of menthol and capsaicin induces eosinophil infiltration to nasal mucosa of mice.
This results suggest that TRPV3 and TRPV1 may induce inflammatory cells such as eosinophils in the mucous membrane.

Academic Significance and Societal Importance of the Research Achievements

副鼻腔炎においても気管支喘息においても、その難治性の原因として粘膜における好酸球性炎症が注目を集めている。しかし、気道における好酸球性炎症の発生メカニズムは未だ不明な点が多い。
本研究においてTRP受容体ファミリーが気道粘膜における好酸球性炎症を誘導している可能性が示された。TRP受容体に対するアンタゴニストを用いることで、好酸球性炎症を制御できることから、今後の治療につながる可能性が期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] The significant expression of TRPV3 in nasal polyps of eosinophilic chronic rhinosinusitis2017

    • Author(s)
      Tokunaga T, Ninomiya T, Kato Y, Imoto Y, Sakashita M, Takabayashi T, Noguchi E, Fujieda S
    • Journal Title

      Allergology International

      Volume: 66 Issue: 4 Pages: 610-616

    • DOI

      10.1016/j.alit.2017.04.002

    • NAID

      130006179515

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 好酸球性副鼻腔炎におけるTRPチャンネルの発現2018

    • Author(s)
      加藤幸宣、高林哲司、徳永貴広、二之宮貴裕、吉田加奈子、森川太洋、意元義政、藤枝重治
    • Organizer
      第57回 日本鼻科学会総会・学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 好酸球性副鼻腔炎におけるTRPV3遺伝子の発現解析2016

    • Author(s)
      徳永 貴広, 意元 義政, 坂下 雅文, 高林 哲司, 藤枝 重治
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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