Functional analysis of TRP receptor family on eosinophilic inflammation in mucous membrane
| Project/Area Number |
16K11208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
Tokunaga Takahiro 福井大学, 学術研究院医学系部門, 特別研究員 (10464075)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 好酸球性炎症 / TRPV3 / TRPV1 / アレルギー・ぜんそく |
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| Outline of Final Research Achievements |
The menthol which activates TRPV3 and the capsaicin which activates TRPV1 induce inflammatory cytokines such as RANTES, TSLP and IL-33 in nasal polyps of eosinophilic chronic rhinosinusitis. On the other hand, antagonists of TRPV3 and TRPV1 suppress the expression of these inflammatory cytokines.
Furthermore, transnasal administration of menthol and capsaicin induces eosinophil infiltration to nasal mucosa of mice.
This results suggest that TRPV3 and TRPV1 may induce inflammatory cells such as eosinophils in the mucous membrane.
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| Academic Significance and Societal Importance of the Research Achievements |
副鼻腔炎においても気管支喘息においても、その難治性の原因として粘膜における好酸球性炎症が注目を集めている。しかし、気道における好酸球性炎症の発生メカニズムは未だ不明な点が多い。
本研究においてTRP受容体ファミリーが気道粘膜における好酸球性炎症を誘導している可能性が示された。TRP受容体に対するアンタゴニストを用いることで、好酸球性炎症を制御できることから、今後の治療につながる可能性が期待できる。
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Report
(4 results)
Research Products
(3 results)
