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Clarification of etiology elucidation of eosinophilic chronic sibusitis and making of the model mouse

Research Project

Project/Area Number 16K11218
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionToho University

Principal Investigator

OTA Yasushi  東邦大学, 医学部, 准教授 (40251285)

Co-Investigator(Kenkyū-buntansha) 石川 文雄  東邦大学, 医学部, 講師 (10130345)
鈴木 光也  東邦大学, 医学部, 教授 (50302724)
池宮城 慶寛  東邦大学, 医学部, 助教 (50439931)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords難治性慢性炎症 / 慢性副鼻腔炎 / IgG4 / デスモグレイン3 / 自己抗体 / 自己抗原 / デスモグレイン3 / 副鼻腔粘膜 / 細胞間隙 / ミクリッツ病 / IgG4 / IgG4-CRS / 好酸球性副鼻腔炎 / アレルギー、喘息 / 自己免疫 / モデルマウス
Outline of Final Research Achievements

I proved autoantibody IgG4 for desmoglein 3 in an intractable chronic rhinosinusitis case. In addition, in six cases of the intractable rhinosinusitis cases, the existence part of IgG4 in the paranasal sinus mucosal epithelium was intercellular space of the epithelium cell. This IgG4 was thought to an antibody in response to a selfantigen. Desmoglein 3 which was representative intercellular space protein existed in the epithelium intercellular space of the paranasal sinus mucosal epithelium. From this, desmoglein 3 was thought to one of the self-antigen of IgG4 which infiltrated a paranasal sinus mucosal epithelium. From this, it was thought that autoantibody IgG4 for desmoglein 3 was one of the causes of intractable chronic rhinosinusitis.

Academic Significance and Societal Importance of the Research Achievements

好酸球性鼻副鼻腔炎に代表される難治性鼻副鼻腔炎は、いまだ難治性慢性炎症がおこるその機序が不明であり、根本的な治療方法も確立されていない。最近患者数も増加しており、その治療方法を確立することは急務である。今回難治性鼻副鼻腔炎の原因の一つに
デスモグレイン3に対する自己抗体IgG4が関与していることが判明した。さらなる研究が必要であると同時に、治療方法の確立に結び付く可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] 【鼻副鼻腔における免疫アレルギー疾患への対応】 難治性慢性鼻副鼻腔炎とIgG4(解説/特集)2018

    • Author(s)
      太田 康
    • Journal Title

      アレルギーの臨床

      Volume: 12 Pages: 1133-1136

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A case of refractory chronic rhinosinusitis with anti-desmoglein 3 IgG4 autoantibody2017

    • Author(s)
      Yasushi Ota, Fumio Ishikawa, Toshiya Sato, Nobuyuki Hiruta,
    • Journal Title

      Allegology International

      Volume: in press

    • NAID

      130006179452

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 副鼻腔粘膜上皮内にIgG4浸潤を認めた慢性鼻副鼻腔炎症例の検討2018

    • Author(s)
      太田 康、鈴木光也
    • Organizer
      第36回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2017 Research-status Report
  • [Presentation] デスモグレイン3に対する自己抗体IgG4が認められた難治性慢性鼻副鼻腔炎症例2017

    • Author(s)
      太田 康、石川文雄、鈴木光也
    • Organizer
      第56回日本鼻科学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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