| Project/Area Number |
16K11231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka City General Hospital (2017-2019)
Osaka University (2016) |
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Principal Investigator |
Hanamoto Atsushi 地方独立行政法人大阪市民病院機構大阪市立総合医療センター(臨床研究センター), 臨床研究センター, 医長 (20625917)
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| Project Period (FY) |
2016-10-21 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 甲状腺癌 / FDG-PET / ワールブルグ効果 |
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| Outline of Final Research Achievements |
We investigated glucose metabolism as a prognostic factor for thyroid cancer. First, we examined FDG-PET, which is currently covered by insurance as a glucose metabolism test. These results showed that preoperative FDG-PET with large SUVmax, which indicates the degree of accumulation, and large tumor metabolic volume had a poor prognosis. As a further study, immunostaining of the excised specimen was performed. Glucose Transporter 1, Lactate Dehydrogenase A, Monocarboxylate Transporter 4, Fatty acid synthetase and Ki-67 were examined, but no significant difference in the degree of staining was observed in the degree of accumulation.
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| Academic Significance and Societal Importance of the Research Achievements |
甲状腺癌はハイリスク群とローリスク群に分けられ、ローリスク群は甲状腺葉切除＋D1郭清、ハイリスク群は甲状腺全摘＋頸部郭清＋ヨード治療が推奨されている。しかし、両群ともに該当しない症例も多くあり、治療指針に関しては各施設にゆだねられている。この両群ともに該当しない症例をさらに細分化して、より正確な個別化治療ができることが望まれる。今回の研究でのFDGの集積の程度で更なる治療法の細分化ができる可能性がある。
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