Gene therapy for head and neck cancer by introducing suppressor of cytokine signaling (SOCS)

• Project/Area Number: 16K11232
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kobe University
• Principal Investigator: Otsuki Naoki 神戸大学, 医学研究科, 准教授 (40343264)
• Co-Investigator(Kenkyū-buntansha): 丹生 健一 神戸大学, 医学研究科, 教授 (20251283)
• Co-Investigator(Renkei-kenkyūsha): Shirakawa Toshiro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 頭頸部癌 / 遺伝子治療 / サイトカインシグナル阻害分子 / サイトカインシグナル阻害因子 / 頭頸部外科学

Outline of Final Research Achievements

The JAK / STAT signaling pathway, which is one of the cytokine signaling pathways activated in head and neck cancer, is suppressed by suppressor of cytokine signaling (SOCS). By overexpression of SOCS3 mediated by adenovirus vector in a head and neck cancer cell line, it was shown that the growth of tumor cells is suppressed.

Academic Significance and Societal Importance of the Research Achievements

頭頸部癌は全悪性腫瘍のうち約５％を占め、その患者数は近年増加傾向にある。サイトカインシグナル伝達の異常とくにJAK/STATシグナル経路は頭頸部癌の発症や増殖に関与していることが知られている。SOCS3遺伝子をアデノウイルスベクターを用いて頭頸部癌細胞株に導入することにより、癌細胞の増殖が抑制されることが示された。SOCS3は頭頸部癌に対する新たな治療ターゲットとして、遺伝子導入による抗腫瘍効果が期待される。

Research Products

• [Journal Article] Functional and oncological outcomes after retropharyngeal node dissection for papillary thyroid carcinoma (2019)
  • Author(s): Otsuki Naoki、Morita Naruhiko、Furukawa Tatsuya、Teshima Masanori、Shinomiya Hitomi、Shinomiya Hirotaka、Nibu Ken-ichi
  • Journal Title: European Archives of Oto-Rhino-Laryngology Volume: 印刷中 Issue: 6 Pages: 1809-1814
  • DOI: 10.1007/s00405-019-05420-w
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Modified spiral tracheoplasty after extensive window resection of trachea for advanced thyroid cancer (2019)
  • Author(s): Otsuki Naoki、Morita Naruhiko、Furukawa Tatsuya、Shinomiya Hirotaka、Teshima Masanori、Kojima Yasutaka、Nibu Ken-ichi
  • Journal Title: Auris Nasus Larynx Volume: 印刷中 Issue: 6 Pages: 946-951
  • DOI: 10.1016/j.anl.2019.02.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of retropharyngeal lymph node dissection in the surgical treatment of hypopharyngeal cancer (2019)
  • Author(s): Teshima Masanori、Otsuki Naoki、Shinomiya Hirotaka、Morita Naruhiko、Furukawa Tatsuya、Morimoto Koichi、Nakamura Tetsu、Hashikawa Kazunobu、Kiyota Naomi、Sasaki Ryohei、Nibu Ken-ichi
  • Journal Title: Head & Neck Volume: 印刷中 Issue: 6 Pages: 1738-1744
  • DOI: 10.1002/hed.25608
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 腫瘍の検査 遺伝子検査 甲状腺がんに対して必要な検査は？ (2017)
  • Author(s): 大月直樹
  • Journal Title: 耳鼻咽喉科・頭頸部外科 増刊号 耳鼻咽喉科検査マニュアル Volume: 89 Pages: 314-314
• [Journal Article] First bite syndrome - An 11-year experience (2017)
  • Author(s): Avincsal M, Hiroshima Y, Shinomiya H, Shinomiya H, Otsuki N, Nibu KI
  • Journal Title: Auris Nasus Larynx Volume: 44 Issue: 3 Pages: 302-305
  • DOI: 10.1016/j.anl.2016.07.012
  • Peer Reviewed
• [Presentation] Surgical approaches for thyroid cancer involving upper mediastinum. (2019)
  • Author(s): Naoki Otsuki, Masanori Teshim, Tatsuya Furukawa, Naruhiko Morita Ken-ichi Nibu
  • Organizer: 6th Congress of Asian Society of Head and Neck Oncology
  • Int'l Joint Research
• [Presentation] 甲状腺癌に対する甲状腺全摘後の副甲状腺機能 (2019)
  • Author(s): 大月直樹 手島直則 四宮弘隆 丹生健一
  • Organizer: 第29回日本頭頸部外科学会
• [Presentation] 50.Postoperative hypoparathyroidism in total thyroidectomy for thyroid cancer. (2018)
  • Author(s): Naoki Otsuki, Masanori Teshima, Naruhiko Morita, Ken-ichi Nibu
  • Organizer: 3th Congress of Asia-Pacific thyroid surgery
  • Int'l Joint Research
• [Presentation] Patterns of neck metastases in surgically treated parotid cancer (2017)
  • Author(s): Naoki OTSUKI, Hitomi SHINOMIYA, , Tatsuya FURUKAWA, Naruhiko MORITA,Ken-ichi NIBU
  • Organizer: The Meeting of 5th Congress of ASHNO
  • Place of Presentation: balli
  • Year and Date: 2017-03-23
  • Int'l Joint Research