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Gene therapy for head and neck cancer by introducing suppressor of cytokine signaling (SOCS)

Research Project

Project/Area Number 16K11232
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKobe University

Principal Investigator

Otsuki Naoki  神戸大学, 医学研究科, 准教授 (40343264)

Co-Investigator(Kenkyū-buntansha) 丹生 健一  神戸大学, 医学研究科, 教授 (20251283)
Co-Investigator(Renkei-kenkyūsha) Shirakawa Toshiro  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords頭頸部癌 / 遺伝子治療 / サイトカインシグナル阻害分子 / サイトカインシグナル阻害因子 / 頭頸部外科学
Outline of Final Research Achievements

The JAK / STAT signaling pathway, which is one of the cytokine signaling pathways activated in head and neck cancer, is suppressed by suppressor of cytokine signaling (SOCS). By overexpression of SOCS3 mediated by adenovirus vector in a head and neck cancer cell line, it was shown that the growth of tumor cells is suppressed.

Academic Significance and Societal Importance of the Research Achievements

頭頸部癌は全悪性腫瘍のうち約5%を占め、その患者数は近年増加傾向にある。サイトカインシグナル伝達の異常とくにJAK/STATシグナル経路は頭頸部癌の発症や増殖に関与していることが知られている。SOCS3遺伝子をアデノウイルスベクターを用いて頭頸部癌細胞株に導入することにより、癌細胞の増殖が抑制されることが示された。SOCS3は頭頸部癌に対する新たな治療ターゲットとして、遺伝子導入による抗腫瘍効果が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Functional and oncological outcomes after retropharyngeal node dissection for papillary thyroid carcinoma2019

    • Author(s)
      Otsuki Naoki、Morita Naruhiko、Furukawa Tatsuya、Teshima Masanori、Shinomiya Hitomi、Shinomiya Hirotaka、Nibu Ken-ichi
    • Journal Title

      European Archives of Oto-Rhino-Laryngology

      Volume: 印刷中 Issue: 6 Pages: 1809-1814

    • DOI

      10.1007/s00405-019-05420-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Modified spiral tracheoplasty after extensive window resection of trachea for advanced thyroid cancer2019

    • Author(s)
      Otsuki Naoki、Morita Naruhiko、Furukawa Tatsuya、Shinomiya Hirotaka、Teshima Masanori、Kojima Yasutaka、Nibu Ken-ichi
    • Journal Title

      Auris Nasus Larynx

      Volume: 印刷中 Issue: 6 Pages: 946-951

    • DOI

      10.1016/j.anl.2019.02.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of retropharyngeal lymph node dissection in the surgical treatment of hypopharyngeal cancer2019

    • Author(s)
      Teshima Masanori、Otsuki Naoki、Shinomiya Hirotaka、Morita Naruhiko、Furukawa Tatsuya、Morimoto Koichi、Nakamura Tetsu、Hashikawa Kazunobu、Kiyota Naomi、Sasaki Ryohei、Nibu Ken-ichi
    • Journal Title

      Head & Neck

      Volume: 印刷中 Issue: 6 Pages: 1738-1744

    • DOI

      10.1002/hed.25608

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 腫瘍の検査 遺伝子検査 甲状腺がんに対して必要な検査は?2017

    • Author(s)
      大月直樹
    • Journal Title

      耳鼻咽喉科・頭頸部外科 増刊号 耳鼻咽喉科検査マニュアル

      Volume: 89 Pages: 314-314

    • Related Report
      2016 Research-status Report
  • [Journal Article] First bite syndrome - An 11-year experience2017

    • Author(s)
      Avincsal M, Hiroshima Y, Shinomiya H, Shinomiya H, Otsuki N, Nibu KI
    • Journal Title

      Auris Nasus Larynx

      Volume: 44 Issue: 3 Pages: 302-305

    • DOI

      10.1016/j.anl.2016.07.012

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Surgical approaches for thyroid cancer involving upper mediastinum.2019

    • Author(s)
      Naoki Otsuki, Masanori Teshim, Tatsuya Furukawa, Naruhiko Morita Ken-ichi Nibu
    • Organizer
      6th Congress of Asian Society of Head and Neck Oncology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 甲状腺癌に対する甲状腺全摘後の副甲状腺機能2019

    • Author(s)
      大月直樹 手島直則 四宮弘隆 丹生健一
    • Organizer
      第29回日本頭頸部外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 50.Postoperative hypoparathyroidism in total thyroidectomy for thyroid cancer.2018

    • Author(s)
      Naoki Otsuki, Masanori Teshima, Naruhiko Morita, Ken-ichi Nibu
    • Organizer
      3th Congress of Asia-Pacific thyroid surgery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Patterns of neck metastases in surgically treated parotid cancer2017

    • Author(s)
      Naoki OTSUKI, Hitomi SHINOMIYA, , Tatsuya FURUKAWA, Naruhiko MORITA,Ken-ichi NIBU
    • Organizer
      The Meeting of 5th Congress of ASHNO
    • Place of Presentation
      balli
    • Year and Date
      2017-03-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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