Inhibitory effects of glucosylceramide on tumorigenesis induced by a carcinogen in mice
| Project/Area Number |
16K11233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
矢間 敬章 鳥取大学, 医学部, 助教 (30444631)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 頭頸部癌 / セラミド / 発癌予防 / 発がん予防 / スフィンゴ脂質 / 癌 |
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| Outline of Final Research Achievements |
In head and neck squamous cell carcinoma, preventing recurrence and second primary cancer is required to improve prognosis. The purpose of the present study was to determine whether dietary glucosylceramide(GluCer) had anti-carcinogenic and anti-tumorigenic effects in a mouse model of HNSCC.
All CB6F1-Tg rasH2@Jcl mice were given 4-nitroquinoline 1-oxide for 24 weeks. GluCer group mice were given a mixture of the normal diet plus GluCer for 24 weeks. Epithelial regions were classified as normal tissue, carcinoma in situ (CIS), or SCC, and the number of each type of region was counted. Compared with the GluCer group mice, control group mice more frequently developed individual and multiple tumors of each type, including CIS and SCC, in the mouth, pharynx, or esophagus. Tumor development was effectively inhibited by dietary glucosylceramide derived from rice bran, indicating that this and related compounds show promise as prophylactic agents for human HNSCC.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、グルコシルセラミドが発癌予防効果を示した。また、使用したグルコシルセラミドは植物由来の抽出物であるため、服用の安全性も高いと考えられる。そのため、本物質が癌予防としての効果を有する物質になる可能性が期待される。
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Report
(4 results)
Research Products
(5 results)
