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The establishment of tumor marker in diagnosing inverted papilloma and sinonasal squamous cell carcinoma

Research Project

Project/Area Number 16K11235
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyushu University

Principal Investigator

Yasumatsu Ryuji  九州大学, 医学研究院, 准教授 (00444787)

Co-Investigator(Kenkyū-buntansha) 中島 寅彦  九州大学, 医学研究院, 准教授 (00284505)
中野 貴史  独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 頭頸科医師 (20770100)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords鼻・副鼻腔腫瘍 / SCC抗原 / 腫瘍マーカー / 鼻・副鼻腔乳頭腫 / 扁平上皮癌 / SCCA1 / SCCA2
Outline of Final Research Achievements

Sinonasal inverted papilloma (IP) is a histologically benign tumor. Differentiating IP from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with IP or SCC. As a result, the serum SCCA1 concentration was significantly higher in the IP group than in the SCC group, whereas the serum SCCA2 level was significantly higher in the SCC group than in the IP group. This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal IP from SCC.
Regarding the relationship high risk HPV infection and SCC-associated IP, we could not find any correlations among them.Our results suggest that high-risk HPV does not play a common role in either the development of IP or in its transformation into carcinoma.

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍の早期発見を目的として腫瘍マーカーが実臨床において用いられている。これまでにSCC抗原が鼻・副鼻腔内反性乳頭腫症例において腫瘍マーカーとして極めて有用であることを報告してきた。ただ、鼻・副鼻腔乳頭腫では癌化を来すことや癌合併を伴うことがあり、SCC抗原のみの測定では腫瘍成分が乳頭腫なのか癌なのか鑑別が困難であるという問題が残されていた。
今回の結果において血清SCC抗原値とともにSCCA1、SCCA2を測定することによって癌と乳頭腫の鑑別が可能であることが示唆された。術前あるいは術後の経過観察や乳頭腫と癌の鑑別も含めた有用な腫瘍マーカーになり得ると考えている。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] The clinical value of serum squamous cell carcinoma antigens 1 and 2 in head and neck squamous cell carcinoma2019

    • Author(s)
      Yasumatsu Ryuji、Nakano Takafumi、Hashimoto Kazuki、Kogo Ryunosuke、Wakasaki Takahiro、Nakagawa Takashi
    • Journal Title

      Auris Nasus Larynx

      Volume: 46 Issue: 1 Pages: 135-140

    • DOI

      10.1016/j.anl.2018.07.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma2018

    • Author(s)
      Yasumatsu Ryuji、Nakano Takafumi、Sato Masanobu、Jiroumaru Rina、Hashimoto Kazuki、Kogo Ryunosuke、Wakasaki Takahiro、Nakashima Torahiko、Nakagawa Takashi
    • Journal Title

      Head & Neck

      Volume: 40 Issue: 12 Pages: 2583-2589

    • DOI

      10.1002/hed.25351

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wnt/β-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland2018

    • Author(s)
      Sato Masanobu、Yamamoto Hidetaka、Hatanaka Yui、Nishijima Toshimitsu、Jiromaru Rina、Yasumatsu Ryuji、Taguchi Kenichi、Masuda Muneyuki、Nakagawa Takashi、Oda Yoshinao
    • Journal Title

      Pathology - Research and Practice

      Volume: 214 Issue: 4 Pages: 586-592

    • DOI

      10.1016/j.prp.2017.12.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma.2017

    • Author(s)
      Yasumatsu R, Nakashima T, Sato M, Nakano T, Kogo R, Hashimoto K, Sawatsubashi M, Nakagawa T
    • Journal Title

      Auris Nasus Larynx

      Volume: 44 Issue: 1 Pages: 98-103

    • DOI

      10.1016/j.anl.2016.04.004

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中咽頭癌を見逃さないコツとpitfall2017

    • Author(s)
      安松隆治
    • Journal Title

      ENTONI

      Volume: 202 Pages: 42-46

    • Related Report
      2017 Research-status Report
  • [Journal Article] 中咽頭癌を見逃さないコツとpitfal2017

    • Author(s)
      安松隆治
    • Journal Title

      ENTONI

      Volume: 202 Pages: 42-46

    • Related Report
      2016 Research-status Report
  • [Presentation] 乳頭腫ウイルスをめぐる諸問題 鼻副鼻腔乳頭腫2018

    • Author(s)
      安松隆治
    • Organizer
      第119回日本耳鼻咽喉科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 甲状腺扁平上皮癌症例の臨床的検討2017

    • Author(s)
      安松隆治、内龍太郎、中野貴文、橋本和樹、古後龍之介、田浦政彦、松尾未央子、中島寅彦、中川尚志
    • Organizer
      第27回日本頭頸部外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] The usefulness of combined measurements of squamous cell carcinoma antigens 1 and 2 in diagnosing inverted papilloma and sinonasal squamous cell carcinoma2017

    • Author(s)
      Yasumatsu R, Nakano T, Kogo R, Hashimoto K, Nakagawa T
    • Organizer
      Combined Otolaryngology Spring Meetings
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Management of squamous cell carcinoma associated with sinonasal inverted papilloma2016

    • Author(s)
      Yasumatsu R
    • Organizer
      The 9th Head and neck cancer conference
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 悪性腫瘍を合併した鼻副鼻腔乳頭腫症例2016

    • Author(s)
      安松隆治
    • Organizer
      第40回日本頭頸部癌学会
    • Place of Presentation
      埼玉県大宮市
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Book] 臨床頭頸部癌学2016

    • Author(s)
      安松隆治,中島寅彦
    • Total Pages
      330
    • Publisher
      南江堂
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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