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SCL-CHEP: analyses of long term effects

Research Project

Project/Area Number 16K11243
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionYokohama City University

Principal Investigator

NAKAYAMA MEIJIN  横浜市立大学, 医学研究科, 客員教授 (20207955)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords喉頭癌 / 頭頸部外科 / 機能温存 / 喉頭部分切除 / 喉頭機能温存 / 喉頭亜全摘出術 / 低侵襲手術 / 手術 / 経口的手術 / 頭頸部癌 / 亜全摘術 / 嚥下機能 / 臨床研究 / 喉頭がん / 音声 / 嚥下
Outline of Final Research Achievements

Twenty-three years has pasted since we at the Kitasato University first introduced Supracricoid Larygectomy with Cricohyoidoepiglottopexy(SCL-CHEP) in 1997. We had studied the anatomical and physiological mechanisms which supported the laryngeal functions after SCL-CHEP and reflected the results to refine the surgical techniques. In this grant period, we analyzed the long-term clinical and oncological results of SCL-CHEP cases in reflect to their pathological examinations. SCL-CHEP showed solid pathological results as an oncological surgery. In the long-term follow-up of swallowing function and vocal quality, both showed stable functional results.

Academic Significance and Societal Importance of the Research Achievements

喉頭癌は頭頸部癌の中でも予後が比較的良好な悪性腫瘍である。しかし、機能温存治療の主役である放射線根治照射後に再発した症例や進行喉頭癌症例は、本邦では喉頭全摘出術が第一選択となる。喉頭全摘出術を受けると、患者さんの生活の質を大きく変えることとなる。喉頭機能温存手術(SCL-CHEP)は、永久気管孔を作らずに、上気道の呼吸を介した生理的生活の質を低下させることもない。本研究では、長期観察例の検討を通して、本術式が包括的に安定した効果を提供することができることが確認され、重要な学術的意義と社会的意義に貢献できた。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2016 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results)

  • [Int'l Joint Research] スタンフォード大学(米国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] The dawn of robotic surgery in otolaryngology: head and neck surgery.2019

    • Author(s)
      Meijin Nakayama
    • Journal Title

      JJCO

      Volume: - Issue: 5 Pages: 404-411

    • DOI

      10.1093/jjco/hyz020

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endoscopic Transoral Hybrid Supracricoid Partial Laryngectomy with Cricohyoidoepiglottopexy2019

    • Author(s)
      Nakayama Meijin、Orosco Ryan K.、Holsinger F. Christopher、Spriano Giuseppe、Succo Giovanni、De Virgilio Armando、Oridate Nobuhiko
    • Journal Title

      Annals of Otology, Rhinology & Laryngology

      Volume: 129 Issue: 3 Pages: 273-279

    • DOI

      10.1177/0003489419885139

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hybrid supracricoid partial laryngectomy with cricohyoidoepiglottopexy via transoral robotic surgery.2018

    • Author(s)
      MEIJIN NAKAYAMA
    • Journal Title

      Laryngoscope

      Volume: - Issue: 9 Pages: 2065-2070

    • DOI

      10.1002/lary.27628

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neoglottal revisions after supracricoid laryngectomy with cricohyoidoepiglottopexy2016

    • Author(s)
      中山明仁、宮本俊輔、清野由輩、岡本旅人、加納孝一
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 47(7) Issue: 7 Pages: 642-645

    • DOI

      10.1093/jjco/hyw044

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] DEVELOPMENT OF NEXT GENERATION SCPL2019

    • Author(s)
      MEIJIN NAKAYAMA
    • Organizer
      ASHNO 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HYBRID SCPL-CHEP: A PERL OF INTERNATIONAL COLLABORATION2019

    • Author(s)
      MEIJIN NAKAYAMA
    • Organizer
      TSOHNS 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of next generation Supracricoid Partial Laryngectomy2019

    • Author(s)
      MEIJIN NAKAYAMA
    • Organizer
      ASHNO 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 喉頭亜全摘の切除限界について2018

    • Author(s)
      中山明仁
    • Organizer
      スタンフォード大学特別招聘セミナー
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2021-02-19  

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