Comprehensive genomic analysis focusing on IGF-1R and EpCAM in recurrent head and neck squamous cell carcinoma
| Project/Area Number |
16K11246
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
森 泰昌 国立研究開発法人国立がん研究センター, 中央病院, 医員 (00296708)
|
|---|
| Project Period (FY) |
2016-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 頭頸部癌 / 再発腫瘍 / EPCAM / IGF-IR / 次世代シーケンサー / IGF-1R / 頭頸部扁平上皮癌 / EpCAM / EPCaM |
|---|
| Outline of Final Research Achievements |
Clinically well-annotated FFPE specimens from 317 patients with HNSCC treated by surgery were examined by all-exon TP53 sequencing using a next-generation sequencer and p53 proein phenotype by immunohistochemistry. Two risk categories were classified as“p53 adverse function”and“p53 favorable function”based on TP53 mutation status and p53 protein phenotype. Local control rates were compared between the risk groups using Fisher’s exact test. Multivariate analysis identified“p53 adverse function”as an independent poor predictor of overall survival, local control, and distant metastasis-free survival. All-exon TP53 sequencing and p53 protein phenotype analysis using FFPE specimens can accurately predict clinical outcomes.
|
| Academic Significance and Societal Importance of the Research Achievements |
頭頸部癌における予後因子に関してはp53は代表的な予後因子であるが、その機能ごとの詳細な検討はされていない。今回の結果からはEPCAMも含め頭頸部癌の予後の予測につながる。頭頸部癌治療の大きなパラダイムシフトとまでは残念ながら至らないが治療方針の決定の一助となる可能性がある。
|
Report
(5 results)
Research Products
(29 results)
-
-
-
-
-
[Journal Article] A surgical approach to schwannomas originating from the esophageal branch of the recurrent laryngeal nerve: Pictorial essay.2019
Author(s)
Kobayashi K, Matsumoto Y, Matsumoto F, Sato T, Mori T, Tsuchida T, Omura G, Matsumura S, Ikeda A, Sakai A, Eguchi K, and Yoshimoto S.
-
Journal Title
Head Neck
Volume: 41
Issue: 11
Pages: 4054-4059
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] All-Exon TP53 Sequencing and Protein Phenotype Analysis Accurately Predict Clinical Outcome after Surgical Treatment of Head and Neck Squamous Cell Carcinoma2019
Author(s)
Kobayashi K, Yoshimoto S, Matsumoto F, Ando M, Murakami N, Omura G, Fukasawa M, Matsumoto Y, Matsumura M, Akamatsu M, Hiraoka N, Eigitsu R, and Mori T
-
Journal Title
Annals of Surgical Oncology
Volume: 印刷中
Issue: 7
Pages: 2294-2303
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] Impact of Surgical Margin in Skull Base Surgery for Head and Neck Sarcomas2018
Author(s)
Matsumoto Fumihiko、Miyakita Yasuji、Mori Taisuke、Shimoi Tatsunori、Murakami Naoya、Yoshida Akihiko、Arakawa Ayumu、Omura Go、Fukasawa Masahiko、Matsumoto Yoshifumi、Matsumura Satoko、Itami Jun、Narita Yoshitaka、Yoshimoto Seiichi、Kobayashi Kenya
-
Journal Title
Journal of Neurological Surgery Part B: Skull Base
Volume: 79
Issue: 05
Pages: 437-444
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Impact of microscopic orbital periosteum invasion in orbital preservation surgery.2017
Author(s)
Kobayashi K, Mori T, Matsumoto F, Murakami N, Teshima M, Fukasawa M, Matsumoto Y, Matsumura S, Itami J, Asai M, Yoshimoto S.
-
Journal Title
Jpn J Clin Oncol.
Volume: 47
Issue: 4
Pages: 321-327
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
