| Project/Area Number |
16K11254
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
HANAI Nobuhiro 愛知県がんセンター(研究所), がん予防研究分野, 研究員 (80381797)
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| Research Collaborator |
FURUKAWA Madoka
MATSUURA Kazuto
FUJIMOTO Yasushi
MONDEN Nobuya
SHIMODE Yuzo
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 超音波検査 / 頭頸部癌 / 化学放射線療法 / 頸部リンパ節転移 / 頭頸部外科学 |
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| Outline of Final Research Achievements |
Cervical lymph node diagnosis was performed using the treatment effect criteria (draft) after CRT by US, and the usefulness of US diagnosis after CRT was evaluated. As a final result, the correct diagnosis rate of US was 81% (specificity 83%, negative predictive value 86%). There were significant changes in size, echo level and blood flow in the observation items before and 12 weeks after treatment. On the other hand, the correct diagnosis rate of PET-CT was 94% (specificity 93%, negative predictive value 100%). Although the correct diagnosis rate was less than that of PET-CT, there is a possibility that the accuracy can be further improved by the improvement of the treatment effect judgment criteria (draft) and the equalization of the interpretation among the practitioners. The US was shown to be excellent in that it was inexpensive and simple, and was minimally invasive and repeatable.
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| Academic Significance and Societal Importance of the Research Achievements |
CRT後の頸部リンパ節診断は正診率においてPET-CTが最も優れると言われるが、PET-CTは設備の偏在、また高額であることから保険制度上の施行制限があり、実臨床ではCTによって診断を行わざるを得ない場面も多い。本研究はCRT後の頸部リンパ節診断におけるUS診断の有用性、またCTに対する優位性を示したものである。USは人体にとって低侵襲であり、反復検査を行うことが出来る。US診断を用いることによって、患者負担を軽減し、医療経済面でもコストの軽減が可能である。
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