Assessment of genetic factors associated with surgical effects in primary open-angle glaucoma

• Project/Area Number: 16K11267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: Akagi Tadamichi 京都大学, 医学研究科, 准教授 (30580112)
• Co-Investigator(Kenkyū-buntansha): 中西 秀雄 京都大学, 医学研究科, 助教 (80724278)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 緑内障 / 流出路再建術 / 遺伝因子 / 手術成績 / 眼圧下降

Outline of Final Research Achievements

In recent years, minimally invasive glaucoma surgery (MIGS) has become a popular first-line surgery worldwide. Intraocular pressure reduction targets and expected success rates were not very different between the MIGS and the classic trabeculotomy.
It was examined whether genetic factors, such as TMCO1, CAV1/CAV2, CDKN2B-AS1, ABCA1, SIX1/SIX6, and LOXL1, were associated with the surgical effects in 377 cases. However, the results were not significant and it might be difficult to use single-nucleotide polymorphism (SNP) as a marker for postoperative outcomes.

Academic Significance and Societal Importance of the Research Achievements

最近の小切開低侵襲緑内障手術が従来のものとおよそ同程度の手術効果が期待できることが確認できたことは、今後も小切開手術を施行していくうえで意義の大きい結果といえる。今回の結果からは緑内障手術の流出路再建術の術後成績を遺伝因子で予測することは困難であることが示唆された。

Research Products

• [Journal Article] A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field. (2019)
  • Author(s): Kadomoto S, Uji A, Muraoka Y, Akagi T, Miyata M, Tsujikawa A.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: in press Issue: 6 Pages: 1199-1206
  • DOI: 10.1007/s00417-019-04310-5
  • Peer Reviewed
• [Journal Article] Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma (2019)
  • Author(s): Hou Huiyuan、Moghimi Sasan、Zangwill Linda M.、Shoji Takuhei、Ghahari Elham、Penteado Rafaella C.、Akagi Tadamichi、Manalastas Patricia Isabel C.、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 199 Pages: 120-132
  • DOI: 10.1016/j.ajo.2018.11.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anterior Segment OCT Angiography Images of Avascular Bleb after Trabeculectomy (2018)
  • Author(s): Akagi T, Okamoto Y, Tsujikawa A
  • Journal Title: Ophthalmology Glaucoma Volume: 2 Issue: 2 Pages: 102-102
  • DOI: 10.1016/j.ogla.2018.10.009
  • Peer Reviewed
• [Journal Article] Baerveldt or Ahmed glaucoma valve implantation with pars plana tube insertion in Japanese eyes with neovascular glaucoma: 1-year outcomes. (2018)
  • Author(s): Masayo Suda, Hideo Nakanishi, Tadamichi Akagi, Tomoaki Murakami, Kiyoshi Suzuma, Kenji Suda, Takanori Kameda, Satoshi Morooka, Hanako O Ikeda, Akitaka Tsujikawa
  • Journal Title: Clinical Ophthalmology Volume: 12 Pages: 2439-2449
  • DOI: 10.2147/opth.s183689
  • NAID: 120006545198
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Structure-Function Relationships in Longitudinal Changes of Glaucoma using the Spectralis OCT Follow-Up Mode (2018)
  • Author(s): Suda Kenji、Akagi Tadamichi、Nakanishi Hideo、Noma Hisashi、Ikeda Hanako Ohashi、Kameda Takanori、Hasegawa Tomoko、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 17158-17158
  • DOI: 10.1038/s41598-018-35419-y
  • NAID: 120006541994
  • Peer Reviewed / Open Access
• [Journal Article] Association between Rates of Retinal Nerve Fiber Layer Thinning and Previous Disc Hemorrhage in Glaucoma (2018)
  • Author(s): Akagi Tadamichi、Saunders Luke J.、Shoji Takuhei、De Moraes Carlos Gustavo、Skaat Alon、Manalastas Patricia Isabel C.、Girkin Christopher A.、Liebmann Jeffrey M.、Zangwill Linda M.、Weinreb Robert N.
  • Journal Title: Ophthalmology Glaucoma Volume: 1 Issue: 1 Pages: 23-31
  • DOI: 10.1016/j.ogla.2018.06.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Visualization of the Lamina Cribrosa Microvasculature in Normal and Glaucomatous Eyes: A Swept-source Optical Coherence Tomography Angiography Study. (2018)
  • Author(s): Numa S, Akagi T, Uji A, Suda K, Nakanishi H, Kameda T, Ikeda HO, Tsujikawa A.
  • Journal Title: J Glaucoma Volume: 27 Issue: 11 Pages: 1032-1035
  • DOI: 10.1097/ijg.0000000000001069
  • Peer Reviewed
• [Journal Article] Conjunctival and Intrascleral Vasculatures Assessed Using Anterior Segment Optical Coherence Tomography Angiography in Normal Eyes (2018)
  • Author(s): Akagi Tadamichi、Uji Akihito、Huang Alex S.、Weinreb Robert N.、Yamada Tatsuya、Miyata Manabu、Kameda Takanori、Ikeda Hanako Ohashi、Tsujikawa Akitaka
  • Journal Title: American Journal of Ophthalmology Volume: 196 Pages: 1-9
  • DOI: 10.1016/j.ajo.2018.08.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography (2018)
  • Author(s): Akagi Tadamichi、Zangwill Linda M.、Shoji Takuhei、Suh Min Hee、Saunders Luke J.、Yarmohammadi Adeleh、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
  • Journal Title: PLOS ONE Volume: 13 Issue: 8 Pages: e0201729-e0201729
  • DOI: 10.1371/journal.pone.0201729
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Outer Plexiform Layer Elevations as a Marker for Prior Ocular Attacks in Patients With Behcet's Disease (2018)
  • Author(s): Kido Ai、Uji Akihito、Morooka Satoshi、Kuroda Yoshimasa、Arichika Shigeta、Akagi Tadamichi、Tsujikawa Akitaka
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 59 Issue: 7 Pages: 2828-2828
  • DOI: 10.1167/iovs.18-24348
  • Peer Reviewed
• [Journal Article] Lacrimal Canaliculus Imaging Using Optical Coherence Tomography Dacryography (2018)
  • Author(s): Fujimoto Masahiro、Uji Akihito、Ogino Ken、Akagi Tadamichi、Yoshimura Nagahisa
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 9808-9808
  • DOI: 10.1038/s41598-018-27802-6
  • NAID: 120006489934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pilot study assessing the structural changes in posttrabecular aqueous humor outflow pathway after trabecular meshwork surgery using swept-source optical coherence tomography (2018)
  • Author(s): Yoshikawa Munemitsu、Akagi Tadamichi、Uji Akihito、Nakanishi Hideo、Kameda Takanori、Suda Kenji、Ikeda Hanako Ohashi、Tsujikawa Akitaka
  • Journal Title: PLOS ONE Volume: 13 Issue: 6 Pages: e0199739-e0199739
  • DOI: 10.1371/journal.pone.0199739
  • NAID: 120006491989
  • Peer Reviewed / Open Access
• [Journal Article] CCDC102B confers risk of low vision and blindness in high myopia (2018)
  • Author(s): Hosoda Yoshikatsu、Nagahama Study group、Yoshikawa Munemitsu、Miyake Masahiro、Tabara Yasuharu、Shimada Noriaki、Zhao Wanting、Oishi Akio、Nakanishi Hideo、Hata Masayuki、Akagi Tadamichi、Ooto Sotaro、Nagaoka Natsuko、Fang Yuxin、Ohno-Matsui Kyoko、Cheng Ching-Yu、Saw Seang Mei、Yamada Ryo、Matsuda Fumihiko、
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 1782-1782
  • DOI: 10.1038/s41467-018-03649-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deep-Layer Microvasculature Dropout by Optical Coherence Tomography Angiography and Microstructure of Parapapillary Atrophy (2018)
  • Author(s): Suh MH, Zangwill LM, Manalastas PIC, Belghith A, Yarmohammadi A, Akagi T, Diniz-Filho A, Saunders L, Weinreb RN
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 59 Issue: 5 Pages: 1995-2004
  • DOI: 10.1167/iovs.17-23046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optical Coherence Tomography Angiography Macular Vascular Density Measurements and the Central 10-2 Visual Field in Glaucoma (2018)
  • Author(s): Penteado RC, Zangwill LM, Daga FB, Saunders LJ, Manalastas PIC, Shoji T, Akagi T, Christopher M, Yarmohammadi A, Moghimi S, Weinreb RN
  • Journal Title: J Glaucoma Volume: 印刷中 Issue: 6 Pages: 1-1
  • DOI: 10.1097/ijg.0000000000000964
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma. Reply. (2018)
  • Author(s): Akagi T, Zangwill LM, Weinreb RN
  • Journal Title: Ophthalmology Volume: 125 Issue: 3 Pages: e22-e23
  • DOI: 10.1016/j.ophtha.2017.10.013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Progression of Primary Open Angle Glaucoma in Diabetic and Non-diabetic Patients (2018)
  • Author(s): Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders LJ, Hasenstab K, Ghahari E, Manalastas PIC, Akagi T, Christopher M, Penteado RC, Weinreb RN
  • Journal Title: Am J Ophthalmol Volume: 189 Pages: 1-9
  • DOI: 10.1016/j.ajo.2018.02.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of Bruch's membrane opening and optic disc morphology to axial length and visual field defects in eyes with primary open-angle glaucoma (2018)
  • Author(s): Nakanishi H, Suda K, Yoshikawa M, Akagi T, Kameda T, Ikeda HO, Yokota S, Kurimoto Y, Tsujikawa A
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 256 Issue: 3 Pages: 599-610
  • DOI: 10.1007/s00417-017-3874-8
  • Peer Reviewed / Open Access
• [Journal Article] Comparative outcomes of trabeculotomy ab externo versus trabecular ablation ab interno for open angle glaucoma (2018)
  • Author(s): Kinoshita-Nakano E, Nakanishi H, Ohashi-Ikeda H, Morooka S, Akagi T
  • Journal Title: Jpn J Ophthalmol Volume: 62 Issue: 2 Pages: 201-208
  • DOI: 10.1007/s10384-017-0559-0
  • Peer Reviewed
• [Journal Article] The Association between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes (2018)
  • Author(s): Manalastas PIC, Zangwill LM, Daga FB, Christopher MA, Saunders LJ, Shoji T, Akagi T, Penteado RC, Yarmohammadi A, Suh MH, Medeiros FA, Weinreb RN
  • Journal Title: J Glaucoma Volume: 27 Issue: 3 Pages: 227-232
  • DOI: 10.1097/ijg.0000000000000862
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes (2017)
  • Author(s): Manalastas PIC, Zangwill LM, Saunders LJ, Mansouri K, Belghith A, Suh MH, Yarmohammadi A, Penteado RC, Akagi T, Shoji T, Weinreb RN
  • Journal Title: J Glaucoma Volume: 26 Issue: 10 Pages: 851-859
  • DOI: 10.1097/ijg.0000000000000768
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study (2017)
  • Author(s): Shoji T, Zangwill LM, Akagi T, Saunders LJ, Yarmohammadi A, Manalastas PIC, Penteado RC, Weinreb RN
  • Journal Title: Am J Ophthalmol Volume: 182 Pages: 107-117
  • DOI: 10.1016/j.ajo.2017.07.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Retinal Blood Flow Velocity Change in Parafoveal Capillary after Topical Tafluprost Treatment in Eyes with Primary Open-angle Glaucoma (2017)
  • Author(s): Iida Y, Akagi T, Nakanishi H, Ohashi Ikeda H, Morooka S, Suda K, Hasegawa T, Yokota S, Yoshikawa M, Uji A, Yoshimura N
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 5019-5019
  • DOI: 10.1038/s41598-017-05258-4
  • NAID: 120006366777
  • Peer Reviewed / Open Access
• [Journal Article] Rates of Local Retinal Nerve Fiber Layer Thinning before and after Disc Hemorrhage in Glaucoma (2017)
  • Author(s): Akagi T, Zangwill LM, Saunders LJ, Yarmohammadi A, Manalastas PIC, Suh MH, Girkin CA, Liebmann JM, Weinreb RN
  • Journal Title: Ophthalmology Volume: 124 Issue: 9 Pages: 1403-1411
  • DOI: 10.1016/j.ophtha.2017.03.059
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of Glaucoma-Susceptible Genes to Regional Circumpapillary Retinal Nerve Fiber Layer Thickness and Visual Field Defects (2017)
  • Author(s): Yoshikawa M, Nakanishi H, Yamashiro K, Miyake M, Akagi T, Gotoh N, Ikeda HO, Suda K, Yamada H, Hasegawa T, Iida Y, Yamada R, Matsuda F, Yoshimura N; Nagahama Study Group
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 58 Issue: 5 Pages: 2510-2519
  • DOI: 10.1167/iovs.16-20797
  • Peer Reviewed / Open Access
• [Journal Article] Peripapillary and Macular Vessel Density in Patients with Glaucoma and Single-Hemifield Visual Field Defect (2017)
  • Author(s): Yarmohammadi A, Zangwill LM, Diniz-Filho A, Saunders LJ, Suh MH, Wu Z, Manalastas PI, Akagi T, Medeiros FA, Weinreb RN
  • Journal Title: Ophthalmology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Longitudinal change in choroidal thickness after trabeculectomy in primary open-angle glaucoma patients (2016)
  • Author(s): Yoshikawa M, Akagi T, Nakanishi H, Ikeda HO, Morooka S, Yamada H, Hasegawa T, Iida Y, Yoshimura N
  • Journal Title: Jpn J Ophthalmol Volume: 61 Issue: 1 Pages: 105-112
  • DOI: 10.1007/s10384-016-0482-9
  • NAID: 210000178255
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influence of high myopia on outcomes of trabeculectomy with mitomycin C in patients with primary open-angle glaucoma (2016)
  • Author(s): Tanaka D, Nakanishi H, Hangai M, Akagi T, Morooka S, Ikeda HO, Yoshimura N
  • Journal Title: Jpn J Ophthalmol Volume: 60 Pages: 446-453
  • Peer Reviewed
• [Journal Article] Microvascular Density in Glaucomatous Eyes with Hemifield Visual Field Defects: An Optical Coherence Tomography Angiography Study (2016)
  • Author(s): Akagi T, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 170 Pages: 248-249
  • DOI: 10.1016/j.ajo.2016.08.018
  • Peer Reviewed
• [Journal Article] Cone Integrity in Glaucoma: An Adaptive-Optics Scanning Laser Ophthalmoscopy Study (2016)
  • Author(s): Hasegawa T, Ooto S, Takayama K, Makiyama Y, Akagi T, Ikeda HO, Nakanishi H, Suda K, Yamada H, Uji A, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 171 Pages: 53-66
  • DOI: 10.1016/j.ajo.2016.08.021
  • Peer Reviewed
• [Journal Article] Morphological Changes after Trabeculectomy in Highly Myopic Eyes with High Intraocular Pressure using Swept-source Optical Coherence Tomography (2016)
  • Author(s): Akagi T, Nakanishi H, Yoshimura N
  • Journal Title: Am J Ophthalmol Case Rep Volume: 29 Pages: 54-60
  • NAID: 120005980848
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clustering of Combined 24-2 and 10-2 Visual Field Grids and Their Relationship With Circumpapillary Retinal Nerve Fiber Layer Thickness (2016)
  • Author(s): Nakanishi H, Akagi T, Suda K, Hasegawa T, Yamada H, Yokota S, Yoshikawa M, Iida Y, Ikeda HO, Morooka S, Ishihara K, Yoshimura N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 57 Issue: 7 Pages: 3203-3210
  • DOI: 10.1167/iovs.15-18798
  • Peer Reviewed
• [Journal Article] Microvascular Density in Glaucomatous Eyes with Hemifield Visual Field Defects: An Optical Coherence Tomography Angiography Study (2016)
  • Author(s): Akagi T, Iida Y, Nakanishi H, Terada N, Morooka S, Yamada H, Hasegawa T, Yokota S, Yoshikawa M, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 168 Pages: 237-249
  • DOI: 10.1016/j.ajo.2016.06.009
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Vascular imaging of optic nerve and retina using OCT-angiography (2018)
  • Author(s): Tadamichi Akagi
  • Organizer: 4th Asia-Pacific Glaucoma Congress
  • Int'l Joint Research / Invited
• [Presentation] 緑内障の眼圧非依存因子アップデート、近視と緑内障の関係 (2018)
  • Author(s): 赤木忠道
  • Organizer: 第29回日本緑内障学会
  • Invited
• [Presentation] 正常眼における前眼部OCTアンギオグラフィーを用いた強膜内血流評価 (2018)
  • Author(s): 赤木忠道、須田謙史、中西秀雄、亀田隆範、池田華子、三宅正裕、宇治彰人、山田達矢、辻川明孝
  • Organizer: 第29回日本緑内障学会
• [Presentation] 緑内障の眼圧下降治療を考える (2018)
  • Author(s): 赤木忠道
  • Organizer: 第69回京大眼科同窓会学会
  • Invited
• [Presentation] Optical Coherence Tomography Angiography Microvasculature Dropout (2017)
  • Author(s): Akagi T, Zangwill LM, Shoji T, Saunders LJ, Manalastas PIC, Penteado RC, Yarmohammadi A, Medeiros FA, Weinreb RN
  • Organizer: American Academy of Ophthalmology
  • Int'l Joint Research
• [Presentation] Rates of Local Retinal Nerve Fiber Layer Thinning (2017)
  • Author(s): Akagi T, Zangwill LM, Saunders LJ, Yarmohammadi A, Manalastas PIC, Suh MH, Girkin CA, Liebmann JM, Weinreb RN
  • Organizer: The Association for Research in Vision and Ophthalmology
  • Int'l Joint Research
• [Presentation] OCT Angiography in Glaucoma Eyes (2017)
  • Author(s): 赤木忠道
  • Organizer: 第28回日本緑内障学会
  • Invited
• [Presentation] 緑内障眼における乳頭出血発症時期と網膜神経線維層菲薄化速度の関係 (2017)
  • Author(s): 赤木忠道、Robert N. Weinreb、庄司拓平、辻川明孝
  • Organizer: 日本臨床眼科学会
• [Presentation] Optical Coherence Tomography Angiography Microvasculature Dropout inside the Optic Disc in Glaucoma Eyes (2017)
  • Author(s): 赤木忠道、庄司拓平、Robert N. Weinreb、辻川明孝
  • Organizer: 第28回日本緑内障学会
• [Presentation] 高眼圧を伴う強度近視眼に対して線維柱帯切除術後に眼球形状変化を認めた症例 (2016)
  • Author(s): 諸岡諭、赤木忠道、中西秀雄、亀田隆範、池田華子、須田謙史、長谷川智子、横田聡、吉川宗光、飯田悠人、吉村長久
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-03
• [Presentation] 補償光学走査型レーザー検眼鏡を用いた緑内障眼での視神経線維束の経時変化 (2016)
  • Author(s): 長谷川智子、大音壮太郎、赤木忠道、中西秀雄、池田華子、亀田隆範、諸岡諭、須田謙史、横田聡、吉川宗光、飯田悠人、高山弘平、吉村長久
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-03
• [Presentation] Swept-source光干渉断層計を用いた流出路再建術前後での強膜内房水流出路の観察 (2016)
  • Author(s): 吉川宗光、赤木忠道、宇治彰人、中西秀雄、池田華子、亀田隆範、諸岡諭、須田謙史、吉村長久
  • Organizer: 第27回日本緑内障学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-09-17
• [Presentation] OCT angiographyによる上下半視野障害の原発開放隅角緑内障眼の視神経乳頭周囲微小血管密度 (2016)
  • Author(s): 飯田悠人、赤木忠道、中西秀雄、池田華子、亀田隆範、諸岡諭、須田謙史、長谷川智子、横田聡、吉村長久
  • Organizer: 第27回日本緑内障学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-09-17
• [Presentation] Evaluation of retinal blood flow speed before and after topical tafluprost treatment in glaucoma patients using adaptive optics scanning laser ophthalmoscopy (2016)
  • Author(s): Iida Y, Akagi T, Nakanishi H, Ikeda HO, Morooka S, Suda K, Hasegawa T, Yamada H, Yoshikawa M, Uji A, Yoshimura N
  • Organizer: The Association for Research in Vision and Ophthalmology
  • Place of Presentation: シアトル（米国）
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Book] 緑内障を見逃さない 眼底・OCT の診かた、第5章 OCTアンギオグラフィーと緑内障診断 (2018)
  • Author(s): 赤木忠道
  • Total Pages: 7
  • Publisher: 日本医事新報社
• [Book] 眼科、特集：今、OCT angiographyでわかること・わからないこと「6.緑内障」 (2017)
  • Author(s): 赤木忠道
  • Total Pages: 8
  • Publisher: 金原出版
• [Book] Retina Medicine, Vol.5, no.2 (2016)
  • Author(s): 赤木忠道
  • Total Pages: 3
  • Publisher: 先端医学社