Analysis of Behcet's disease and the associated genes in Central Asian countries
| Project/Area Number |
16K11297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
南場 研一 (南塲 研一) 北海道大学, 大学病院, 講師 (70333599)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ベーチェット病 / 中央アジア / カザフスタン / モンゴル / キルギスタン / ネパール / 遺伝子 / ゲノム |
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| Outline of Final Research Achievements |
The topics of this project are following, (1) presence or absence of Behcet's disease in internal region of Eurasian continent, (2) if presence, the symptoms are similar or different from Japanese patients, and (3) the patients have same disease associated genes or not compared to other countries.
Behcet's patients were observed in Azerbaijani, Armenian, Chechen, Dagestan, Russian, Kazakh, and Mongolian. We saw many Behce's patients in Mongol particularly. Their clinical symptoms are similar to those of Japanese patients. Some of them have HLA-B51, that is the most associated gene. However, the prevalence of the gene is still unknown in those countries among healthy population. Gene analysis is now in progress.
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| Academic Significance and Societal Importance of the Research Achievements |
ベーチェット病は古代シルクロード沿いに多発地域が偏在する。途中の中央アジアやモンゴル、カフカス地方は未調査の空白地域であるが、この地域でも患者が存在することを明らかにした。またその臨床像は日本人と同様であった。疾患関連遺伝子 HLA-B51 は東へ行くほど眼症状との関連が強くなり、またアレルギー症状と逆相関した。失明率の高い難病の重症化あるいは軽症化のメカニズム、生活環境や衛生状態と発症との関連に医学的手がかりを得た。さらに調査対象諸国の医師に本病の診断法などを伝え、ディスカッションを通じて、これらの国々の医療水準の向上にもいくばくか貢献できたと考える。
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] HLA-B51 carriers are susceptible to ocular symptoms of Behcet disease and the association between the two becomes stronger towards the east along the silk road: A literature survey.2017
Author(s)
Horie Y, Meguro A, Ohta T, Lee EB, Namba K, Mizuuchi K, Iwata D, Mizuki N, Ota M, Inoko H, Ishida S, Ohno S, Kitaichi N.
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Journal Title
Ocul Immunol Inflamm.
Volume: 25(1)
Issue: 1
Pages: 37-40
DOI
Related Report
Peer Reviewed
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[Journal Article] Investigation of the association between IL10 gene polymorphisms and Vogt-Koyanagi-Harada disease in a Japanese population.2016
Author(s)
Kaori Higashia, Akira Meguroa, Masaki Takeuchiab, Takahiro Yamanea, Nobuyoshi Kitaichic, Yukihiro Horiec, Kenichi Nambad, Shigeaki Ohnod, Kumiko Nakaoe, Taiji Sakamotoe, at el.
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Journal Title
Ophthalmic Genetics
Volume: -
Issue: 2
Pages: 187-189
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Ocular Behcet’s disease is less complicated with allergic disorders. A nationwide survey in Japan.2016
Author(s)
Horie Y, Kitaichi N, Hijioka K, Sonoda K, Saishin Y, Kezuka T, Goto H, Takeuchi M, Nakamura S, Kimoto T, Shimakawa M, Kita M, Sugita S, Mochizuki M, Hori J, Iwata M, Shoji J, Fukuda M, Kaburaki T, Numaga J, Kawashima H, Fukushima A, Joko T, Takai N, Ozawa Y, Meguro A, Mizuki N, Namba K, Ishida S, Ohno S.
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Journal Title
Clin Exp Rheumatol.
Volume: 102
Pages: 1100-1105
Related Report
Peer Reviewed
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[Journal Article] Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease.2016
Author(s)
Tagawa Y, Namba K, Mizuuchi K, Takemoto Y, Iwata D, Uno T, Fukuhara T, Hirooka K, Kitaichi N, Ohno S, Ishida S
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Journal Title
Br J Ophthalmol
Volume: 100
Issue: 4
Pages: 473-477
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Choroidal circulation impairment during the anterior recurrence of Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy.2016
Author(s)
Takemoto Y, Namba K, Uno T, Mizuuchi K, Iwata D, Ohno S, Hirooka K, Hashimoto Y, Saito W, Sugiyama K, Ishida S.
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Journal Title
Acta Ophthalmol.
Volume: 94
Issue: 7
Pages: 629-636
DOI
Related Report
Peer Reviewed / Open Access
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