Development of contact lens new design for myopia control based on higher-order aberration theory

Research Project

Project/Area Number	16K11316
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Ophthalmology
Research Institution	University of Tsukuba
Principal Investigator	Hiraoka Takahiro 筑波大学, 医学医療系, 講師 (30359575)
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	近視 / 高次収差 / コンタクトレンズ / 調節 / 視機能 / 眼軸長 / 眼科学
Outline of Final Research Achievements	We accumulated a large set of clinical data from myopic schoolchildren, and analyzed those in detail. As a result, a close relationship between some components of higher-order aberrations (HOA) and myopia progression (axial elongation) was observed. These findings were reported as a scientific article (Hiraoka T, et al. Relationship between higher-order wavefront aberrations and natural progression of myopia in schoolchildren. Sci Rep. 2017). In addition, we experimentally produce a specially-designed soft contact lens (SCL) with appropriate amounts of HOA. Eight normal volunteers wore the lens, and various examinations were performed. The SCL significantly reduce accommodative responses for near sight and accommodative microfluctuations. This indicated that the specially-designed lens can decrease accommodative burden and ocular fatigue especially at near work.
Academic Significance and Societal Importance of the Research Achievements	一連の研究により，高次収差の増加が調節負荷の軽減を介して近視進行や眼軸長伸長に抑制的に働くというメカニズムの一部を証明することができた．この光学メカニズムを最大限に利用することにより，非常に有効な近視進行抑制法の臨床応用が実現できる可能性が広がり，将来的な病的近視や近視関連合併症の発生を減少させるという観点から，その医学的・社会的意義は極めて大きいと考えられる．