| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal disorders characterized by progressive photoreceptor degeneration leading to a reduction of vision. . However, the mechanisms of deconstruction and reprogramming of the middle and inner retina during and after the photoreceptor degeneration has not been elucidated. In the current study we used rhodopsin Pro347Leu transgenic rabbits (P347L Tg) as an animal model of RP and investigated the change of the inner retina in the course of photoreceptor degeneration. In the middle stage of retinal degeneration, enhancement of function in retinal bipolar cells was detected. In the end stage of RP, severe gliosis was observed and damaged the inner retinal function. However the structure of the optic nerve was relatively preserved.
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