• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Change of inner retinal function and sturcture in retinitis pigmentosa

Research Project

Project/Area Number 16K11320
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNagoya University

Principal Investigator

Ueno Shinji  名古屋大学, 医学部附属病院, 講師 (80528670)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords網膜色素変性 / リモデリング / 網膜変性 / 遺伝子改変動物 / 網膜電図 / 網膜変性モデル / 遺伝子改変ウサギ / 双極細胞 / フリッカERG
Outline of Final Research Achievements

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal disorders characterized by progressive photoreceptor degeneration leading to a reduction of vision. . However, the mechanisms of deconstruction and reprogramming of the middle and inner retina during and after the photoreceptor degeneration has not been elucidated. In the current study we used rhodopsin Pro347Leu transgenic rabbits (P347L Tg) as an animal model of RP and investigated the change of the inner retina in the course of photoreceptor degeneration. In the middle stage of retinal degeneration, enhancement of function in retinal bipolar cells was detected. In the end stage of RP, severe gliosis was observed and damaged the inner retinal function. However the structure of the optic nerve was relatively preserved.

Academic Significance and Societal Importance of the Research Achievements

現在網膜色素変性に対しては、人工網膜、遺伝子治療、光感受性遺伝子の導入など様々な治療法が試みられている。その多くの治療が、視細胞消失後の網膜内層機能を利用しようとするものである。しかし、視細胞消失後にどのような変化が起きているかについては今まで詳細に研究されてこなかった。今回の研究は、ウサギという、比較的長寿のモデル動物を使うことにより、長期にわたる網膜内層の変化を観察できた。本研究の結果は、視細胞の消失に伴い網膜内層にもかなりの形態の障害をきたしていることを示しており、今後の治療法の開発には網膜内層の変化を考慮すべきであることを示していた。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 8 results)

  • [Journal Article] Electrically Evoked Potentials Are Reduced Compared to Axon Numbers in Rhodopsin P347L Transgenic Rabbits With Severe Photoreceptor Degeneration.2019

    • Author(s)
      Kominami T, Ueno S, Nishida K, Inooka D, Kominami A, Kondo M, Terasaki H.
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 60 Issue: 7 Pages: 2543-2550

    • DOI

      10.1167/iovs.19-26972

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Course of loss of photoreceptor function and progressive Mueller cell gliosis in rhodopsin P347L transgenic rabbits.2019

    • Author(s)
      Ueno S, Kominami T, Okado S, Inooka D, Kondo M, Terasaki H.
    • Journal Title

      Experimental Eye Research

      Volume: 184 Pages: 192-200

    • DOI

      10.1016/j.exer.2019.04.026

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three cases of acute-onset bilateral photophobia2019

    • Author(s)
      Ueno Shinji、Inooka Daiki、Meinert Monika、Ito Yasuki、Tsunoda Kazushige、Fujinami Kaoru、Iwata Takeshi、Ohde Hisao、Terasaki Hiroko
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 63 Issue: 2 Pages: 172-180

    • DOI

      10.1007/s10384-018-00649-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant Relationship of Visual Field Sensitivity in Central 10° to Thickness of Retinal Layers in Retinitis Pigmentosa.2018

    • Author(s)
      Sayo A, Ueno S, Kominami T, Okado S, Inooka D, Komori S, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 2;59(8) Issue: 8 Pages: 3469-3475

    • DOI

      10.1167/iovs.18-24635

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations Between Outer Retinal Structures and Focal Macular Electroretinograms in Patients With Retinitis Pigmentosa.2017

    • Author(s)
      Kominami T, Ueno S, Kominami A, Nakanishi A, Yasuda S, Piao CH, Okado S, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 1;58 Issue: 12 Pages: 5122-5128

    • DOI

      10.1167/iovs.17-22040

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temporal Properties of Flicker ERGs in Rabbit Model of Retinitis Pigmentosa.2017

    • Author(s)
      Okado S, Ueno S, Kominami T, Nakanishi A, Inooka D, Sayo A, Kondo M, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 1;58 Issue: 12 Pages: 5518-5525

    • DOI

      10.1167/iovs.17-22332

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa.2017

    • Author(s)
      Sayo A, Ueno S, Kominami T, Nishida K, Inooka D, Nakanishi A, Yasuda S, Okado S, Takahashi K, Matsui S, Terasaki H.
    • Journal Title

      Sci Rep

      Volume: 27;7 Issue: 1 Pages: 16383-16383

    • DOI

      10.1038/s41598-017-16640-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantification of Macular Microvascular Changes in Patients With Retinitis Pigmentosa Using Optical Coherence Tomography Angiography.2017

    • Author(s)
      Inooka D, Ueno S, Kominami T, Sayo A, Okado S, Ito Y, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 1;59 Issue: 1 Pages: 433-438

    • DOI

      10.1167/iovs.17-23202

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contributions of Second- and Third-Order Retinal Neurons to Cone Electroretinograms After Loss of Rod Function in Rhodopsin P347L Transgenic Rabbits2017

    • Author(s)
      Kominami T, Ueno S, Okado S, Nakanishi A, Kondo M, Terasaki H
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 58 Issue: 3 Pages: 1417-1424

    • DOI

      10.1167/iovs.16-20344

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi