High-resolution Imaging using next generation adaprive optics imaging in dry age-related macular degeneration

• Project/Area Number: 16K11321
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: OOTO SOTARO 京都大学, 医学研究科, 特定講師 (10511850)
• Co-Investigator(Kenkyū-buntansha): 池田 華子 京都大学, 医学研究科, 准教授 (20372162)
• Research Collaborator: YAMASHIRO KENJI
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 補償光学 / 加齢黄斑変性 / 脈絡膜 / 視細胞 / 光干渉断層計 / 走査型レーザー検眼鏡 / 眼科学 / 網膜 / 眼底イメージング

Outline of Final Research Achievements

We showed photoreceptor abnormalities in dry arge-related macular degeneration using next generation adaptive optics scanning laser ophthalmoscopy. Photoreceptor density was decreased in dry age-related macular degeneration, compared with normal eyes. Abnormalities were also seen in choroidal circulation. Photoreceptor abnormalities were seen in widespread areas surrouding retinal pigment epithelial abnormalities, and mostly correlated with retinal sensitivity. We called "pachychoroid geographic atrophy" as eyes with pachychoroid phenotype and no drusen. Pachychoroid geographic atrophy was different from dry age-related macular degeneration genetically and phonotypically.

Academic Significance and Societal Importance of the Research Achievements

補償光学を利用した、次世代の眼底イメージング機器を用いて、現在まで病態が不明のままである萎縮型加齢黄斑変性の視細胞異常をはじめて示した。脈絡膜血流のイメージングも世界初であった。また視細胞異常が網膜色素上皮異常の周囲にまで拡大しているという結果は、萎縮型加齢黄斑変性の治療戦略に大きな影響を与えるものである。新しく提唱したpachychoroid geographic atrophyという疾患概念は、従来からの萎縮型加齢黄斑変性と異なるものであり、今後の研究では区別して考えるべきである。

Research Products

• [Journal Article] Pachychoroid Geographic Atrophy: Clinical and Genetic Characteristics (2018)
  • Author(s): 10.Takahashi A, Ooto S, Yamashiro K, Tamura H, Oishi, A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A.
  • Journal Title: Ophthalmology Retina Volume: in press Issue: 4 Pages: 295-305
  • DOI: 10.1016/j.oret.2017.08.016
  • Peer Reviewed
• [Journal Article] Pachychoroid geographic atrophy. Clinical and genetic characteristics (2018)
  • Author(s): Takahashi A, Ooto S, Yamashiro K, et al.
  • Journal Title: Ophthalmology Retina Volume: 2 Pages: 295-305
  • Peer Reviewed
• [Journal Article] Photoreceptor Damage and Reduction of Retinal Sensitivity Surrounding Geographic Atrophy in Agerelated Macular Degeneration (2016)
  • Author(s): Takahashi A, Ooto S, Yamashiro K, Oishi A, Tamura H, Nakanishi H, UedaArakawa N, Tsujikawa A, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 2016 Pages: 260-8
  • DOI: 10.1016/j.ajo.2016.06.006
  • Peer Reviewed
• [Journal Article] Clinical and Genetic Characteristics of Japanese AgeRelated Macular Degeneration Patients with Pseudodrusen (2016)
  • Author(s): Elfandi S, Ooto S, UedaArakawa N, Takahashi A, Yoshikawa M, Nakanishi H, Tamura H, Oishi A, Yamashiro K, Yoshimura N
  • Journal Title: Ophthalmology Volume: 2016 Issue: 10 Pages: 2205-12
  • DOI: 10.1016/j.ophtha.2016.06.052
  • Peer Reviewed
• [Presentation] 補償光学の医科領域への応用：AO-SLOによる眼底イメージング (2018)
  • Author(s): 大音壮太郞
  • Organizer: 第11回NIBBバイオイメージングフォーラム
  • Invited
• [Presentation] 中心性漿液性脈絡網膜症におけるpachydrusenの頻度と臨床的・遺伝学的特徴 (2018)
  • Author(s): 高橋綾子、大音壮太郎、山城健児ら
  • Organizer: 日本眼科学会
• [Presentation] 補償光学の医科領域への応用：AO-SLOによる眼底イメージング (2017)
  • Author(s): 大音壮太郎
  • Organizer: 第11回NIBBバイオイメージングフォーラム
  • Place of Presentation: 岡崎市
  • Year and Date: 2017-02-14
  • Invited
• [Presentation] 最新の画像診断機器 (OCT・SLO) ~広角・高解像度・angio~ (2016)
  • Author(s): 大音壮太郎
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台市
  • Year and Date: 2016-04-07
  • Invited