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Molecularly targeted therapy and photo dynamic therapy for refractory lymphangioma

Research Project

Project/Area Number 16K11351
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Fumino Shigehisa  京都府立医科大学, 医学(系)研究科(研究院), 助教 (40405254)

Co-Investigator(Kenkyū-buntansha) 東 真弓  京都府立医科大学, 医学(系)研究科(研究院), 助教 (10380453)
古川 泰三  京都府立医科大学, 医学(系)研究科(研究院), 講師 (20515291)
田尻 達郎  京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsリンパ管腫 / 小児外科
Outline of Final Research Achievements

This study was attempted to develop molecularly targeted therapy and photo dynamic therapy for refractory lymphangioma. Though, the technical difficulty was proved in the development of rat model.
Finally, we attempted clinical application of mTOR inhibitor for patients with refractory lymphangioma. The results of this study is due to be released in near future.

Academic Significance and Societal Importance of the Research Achievements

現在特許出願および臨床研究の一環であるため,結果を公表することはできないが,本研究はリンパ管腫治療を大きく変える可能性がある.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (35 results)

All 2019 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (19 results) (of which Int'l Joint Research: 16 results) Book (7 results)

  • [Journal Article] Thoracoscopic resection for mediastinal thymolipoma in a child2019

    • Author(s)
      Furukawa T, Sakai K, Higashi M, Fumino S, Aoi S, Tajiri T
    • Journal Title

      Asian J Endosc Surg

      Volume: 12 Issue: 2 Pages: 218-221

    • DOI

      10.1111/ases.12627

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo effects of short-and long-term MAPK pathway inhibition against neuroblastoma.2018

    • Author(s)
      Takeuchi T, Tanaka T, Higashi M, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T
    • Journal Title

      J Pediatr Surg

      Volume: 53 Issue: 12 Pages: 2454-2459

    • DOI

      10.1016/j.jpedsurg.2018.08.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thoracoscopic Repair for Postoperative Chylothorax Using Tissue Sealing Sheet, Polyglycolic Acid Sheet, and Fibrin Glue in a Boy With Malignant Mediastinal Germ Cell Tumor2018

    • Author(s)
      都甲さゆり,井上真帆,文野誠久,坂井宏平,東 真弓,青井重善,古川泰三,小関道夫,田尻達郎
    • Journal Title

      Journal of the Japanese Society of Pediatric Surgeons

      Volume: 54 Issue: 1 Pages: 111-115

    • DOI

      10.11164/jjsps.54.1_111

    • NAID

      130006386731

    • ISSN
      0288-609X, 2187-4247
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical procedure for giant infantile retroperitoneal teratoma based on preoperative 3D-CT findings: Two case reports2018

    • Author(s)
      竹内雄毅,文野誠久,古川泰三,内藤泰行,飯田 拓,小関道夫,田尻達郎
    • Journal Title

      The Japanese Journal of Pediatric Hematology / Oncology

      Volume: 55 Issue: 2 Pages: 194-198

    • DOI

      10.11412/jspho.55.194

    • NAID

      130007427887

    • ISSN
      2187-011X, 2189-5384
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced surgical strategy for giant mediastinal germ cell tumor in children.2017

    • Author(s)
      Fumino S, Sakai K, Higashi M, Aoi S, Furukawa T, Yamagishi M, Inoue M, Iehara T, Hosoi H, Tajiri T
    • Journal Title

      J Pediatr Surg Case Rep

      Volume: 27 Pages: 51-55

    • DOI

      10.1016/j.epsc.2017.09.023

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laparoscopic intraperitoneal onlay mesh for pediatric incisional hernia - a case report.2017

    • Author(s)
      Inoue M, Aoi S, Taniguchi A, Sakai K, Higashi M, Fumino S, Furukawa T, Tajiri T
    • Journal Title

      Surg Case Rep

      Volume: 3 Issue: 1 Pages: 122-122

    • DOI

      10.1186/s40792-017-0400-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient direct conversion of human fibroblasts into myogenic lineage induced by co-transduction with MYCL and MYOD12017

    • Author(s)
      Wakao J, Kishida T, Fumino S, Kimura K, Yamamoto K, Kotani SI, Mizushima K, Naito Y, Yoshikawa T, Tajiri T, Mazda O
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 488 Issue: 2 Pages: 368-373

    • DOI

      10.1016/j.bbrc.2017.05.059

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical intervention and perioperative risk factors of retroperitoneal teratomas in children: a single institution experience.2016

    • Author(s)
      Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T
    • Journal Title

      Pediatr Surg Int

      Volume: 32 Issue: 9 Pages: 909-914

    • DOI

      10.1007/s00383-016-3938-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MEK inhibitors as a novel therapy for neuroblastoma: Their in vitro effects and predicting their efficacy.2016

    • Author(s)
      Tanaka T, Higashi M, Kimura K, Wakao J, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T
    • Journal Title

      J Pediatr Surg

      Volume: 51 Issue: 12 Pages: 2074-2079

    • DOI

      10.1016/j.jpedsurg.2016.09.043

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] リンパ管腫に対する集学的治療の中のOK-432硬化療法の位置づけ.2018

    • Author(s)
      文野誠久,坂井宏平,東真弓,青井重善,古川泰三,田尻達郎
    • Organizer
      第118回日本外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小腸捻転を起こしたびまん性腸間膜リンパ管腫の一例.2018

    • Author(s)
      瀧本篤朗,文野誠久,竹本正和,坂井宏平,東 真弓,青井重善,古川泰三,田尻達郎
    • Organizer
      第54回小児外科学会近畿地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 巨大頸部リンパ管腫切除におけるNerve Integrity Monitor(NIM)による顔面神経モニタリングの使用経験.2018

    • Author(s)
      文野誠久,富樫佑一,髙山勝平,古川泰三,坂井宏平,東 真弓,青井重善,杉山庸一郎,平野 滋,田尻達郎
    • Organizer
      第38回日本小児内視鏡外科・手術手技研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Advanced Surgical Strategy for Giant Mediastinal Germ Cell Tumor in Children.2017

    • Author(s)
      Fumino S, Sakai K, Higashi M, Aoi S, Furukawa T, Yamagishi M, Inoue M, Iehara T, Hosoi H, Tajiri T
    • Organizer
      50th Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Direct Conversion of Human Fibroblasts Toward the Myogenic Cell Lineage: The implications of Diaphragmatic Regeneration.2017

    • Author(s)
      Wakao J,Kishida T,Fumino S,Kimura K,Higashi M,Aoi S,Furukawa T,Mazda O,Tajiri T
    • Organizer
      50th Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Immunohistochemical analysis of pre- and post-chemotherapeutic ERK phosphorylation in clinical neuroblastoma samples.2017

    • Author(s)
      Tanaka T,Takeuchi Y,Higashi M,Fumino S,Iehara T,Hosoi H,Sakai T,Tajiri T
    • Organizer
      3rd Asia-Pacific International Symposium of Neuroblastoma
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Preclinical study of novel MEK inhibitors on neuroblastoma and the biomarker for their therapeutic effects in neuroblastoma xenograft mice.2017

    • Author(s)
      Takeuchi Y, Tanaka T, Higashi M, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T
    • Organizer
      3rd Asia-Pacific International Symposium of Neuroblastoma
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Current surgical intervention for pediatric giant mediastinal germ cell tumors.2017

    • Author(s)
      Fumino S, Sakai K, Higashi M, Aoi S, Furukawa T, Yamagishi M, Inoue M, Iehara T, Hosoi H, Tajiri T
    • Organizer
      9th Congress of the International Society of Paediatric Oncology (SIOP)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Treatment strategies for different types of lymphangioma. 28-years experience in a single institution.2016

    • Author(s)
      17)Kimura O, Furukawa T, Fumino S, Aoi S, Tajiri T
    • Organizer
      68th Annual Autum Congress of the Korean Surgical Society,
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Retroperitoneal teratomas in children: still challenging for surgeons.2016

    • Author(s)
      Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T
    • Organizer
      40th World Congress of the International College of Surgeons
    • Place of Presentation
      京都
    • Year and Date
      2016-10-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] JNK-STAT3 pathway in neuroblastoma.2016

    • Author(s)
      Higashi M, Sakai K, Fumino S, Aoi S, Furukawa T, Tajiri T
    • Organizer
      40th World Congress of the International College of Surgeons
    • Place of Presentation
      京都
    • Year and Date
      2016-10-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Immunohistochemical staining of phosphorylated-ERK as a predictor of therapeutic effects of MEK inhibitors on neuroblastoma.2016

    • Author(s)
      Tanaka T, Higashi M, Wakao J, Kimura K Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T
    • Organizer
      40th World Congress of the International College of Surgeons,
    • Place of Presentation
      京都
    • Year and Date
      2016-10-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Perioperative management and surgical intervention for retroperitoneal teratomas in children.2016

    • Author(s)
      Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T
    • Organizer
      48th Congress of the International Society of Paediatric Oncology (SIOP)
    • Place of Presentation
      Dublin,Ireland
    • Year and Date
      2016-10-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Postoperative bowel management for the patients with anorectal malformation associating spinal lesions: A single institute experience.2016

    • Author(s)
      Aoi S, Furukawa T, Higashi M, Sakai K, Fumino S, Kimura O, Tajiri T
    • Organizer
      International Children's Continence Society
    • Place of Presentation
      京都
    • Year and Date
      2016-06-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] MEK inhibitors as a novel therapy for neuroblastoma: Their in vitro effects & predicting their efficacy.2016

    • Author(s)
      Tanaka T, Higashi M, Kimura K, Wakao J, Fumino S, Iehara T, Hosoi H, Sakai T, Tajiri T
    • Organizer
      49th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS)
    • Place of Presentation
      Kauai,USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surgical management and perioperative risk factors of retroperitoneal teratomas in children: A single institution experience.2016

    • Author(s)
      Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T
    • Organizer
      49th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS)
    • Place of Presentation
      Kauai,USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A clinical trial of low-dose mTOR inhibitor therapy for the treatment of children with refractory lymphatic anomaly.2016

    • Author(s)
      Furukawa T, Sakai K, Higashi M, Fumino S, Aoi S, Kimura O, Ozeki M, Tajiri T
    • Organizer
      49th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS)
    • Place of Presentation
      Kauai,USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tumor-homing effect of human mesenchymal stem cells in a TH-MYCN mouse model of neuroblastoma.2016

    • Author(s)
      Kimura K, Kishida T, Wakao J, Tanaka T, Higashi M, Fumino S, Aoi S, Furukawa T, Mazda O, Tajiri T
    • Organizer
      49th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS)
    • Place of Presentation
      Kauai,USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Thoracoscopic resection of ectopic mediastinal parathyroid adenoma utilizing gamma probe and intraoperative PTH monitoring in a child.2016

    • Author(s)
      Furukawa T, Fumino S, Sakai K, Higashi M, Aoi S, Tajiri T
    • Organizer
      IPEG’s 25th Annual Congress for Endosurgery in Children
    • Place of Presentation
      福岡
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] Pancreaticobiliary maljunction and congenital biliary dilatation2018

    • Author(s)
      Fumino S
    • Total Pages
      261
    • Publisher
      Springer Nature Singapore
    • ISBN
      9789811086533
    • Related Report
      2018 Annual Research Report
  • [Book] 標準小児外科学 第7版 第22章小児腫瘍 B神経芽腫2017

    • Author(s)
      髙松 英夫 田尻 達郎
    • Total Pages
      432
    • Publisher
      医学書院
    • ISBN
      9784260027809
    • Related Report
      2017 Research-status Report
  • [Book] 標準小児外科学 第7版 G悪性リンパ腫2017

    • Author(s)
      髙松 英夫 田尻 達郎
    • Total Pages
      432
    • Publisher
      医学書院
    • ISBN
      9784260027809
    • Related Report
      2017 Research-status Report
  • [Book] 標準小児外科学 第7版 Iその他の良性腫瘍2017

    • Author(s)
      髙松 英夫 田尻 達郎
    • Total Pages
      432
    • Publisher
      医学書院
    • ISBN
      9784260027809
    • Related Report
      2017 Research-status Report
  • [Book] スタンダード小児がん手術 : 臓器別アプローチと手技のポイント2017

    • Author(s)
      田口 智章、黒田 達夫 田尻 達郎
    • Total Pages
      313
    • Publisher
      メジカルビュー社
    • ISBN
      9784758304658
    • Related Report
      2017 Research-status Report
  • [Book] Ⅷ.血液,腫瘍 固形腫瘍(神経芽腫)2017

    • Author(s)
      山岸 敬幸 田尻 達郎
    • Total Pages
      407
    • Publisher
      診断と治療社
    • Related Report
      2017 Research-status Report
  • [Book] 小児疾患診療のための病態生理 改訂第5版【Ⅶ.血液・腫瘍性疾患】性腺腫瘍2016

    • Author(s)
      文野誠久,田尻達郎
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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