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Kampo medicines rikkunshito and hangeshashinto prevent cisplatin-induced intestinal mucosal injury in rats

Research Project

Project/Area Number 16K11357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionKindai University (2017-2019)
Hyogo Medical University (2016)

Principal Investigator

SASAKI Takashi  近畿大学, 医学部, 准教授 (20388573)

Co-Investigator(Kenkyū-buntansha) 大植 孝治  兵庫医科大学, 医学部, 教授 (50314315)
田中 夏美  兵庫医科大学, 医学部, 助教 (20456958)
銭谷 昌弘  兵庫医科大学, 医学部, 助教 (40643531)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords漢方 / 六君子湯 / 半夏瀉心湯 / 化学療法 / シスプラチン / 腸粘膜保護 / 腸管粘膜傷害 / アポトーシス / 小児がん / 副作用抑制 / 漢方薬 / 抗癌剤 / 腸管粘膜障害
Outline of Final Research Achievements

We examined the effects and mechanisms of rikkunshito (RKT) and hangeshashinto (HST) on cisplatin-induced mucosal injuries in the rat small bowel. Juvenile rats were divided into 6 groups: sham control, cisplatin injection without kampo medicines, and cisplatin injection with oral administration of low and high doses of RKT (1000 mg/kg and 2000 mg/kg) and HST (500 mg/kg and 1000 mg/kg). RKT and HST prevented cisplatin-induced intestinal mucosal injury with increasing proliferation of intestinal epithelial cells. HST also attenuated cisplatin-induced crypt cell apoptosis.

Academic Significance and Societal Importance of the Research Achievements

本検討により、RKTやHSTを化学療法中あるいは開始前から投与することにより小腸粘膜傷害の予防効果が期待され、小児がん患児のQOL向上に寄与する可能性が示唆された。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2019

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Kampo medicines rikkunshito and hangeshashinto prevent intestinal mucosal injury induced by cisplatin in rats2019

    • Author(s)
      Zenitani M, Sasaki T, Oue T
    • Organizer
      32nd International Symposium on Paediatric Surgical Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シスプラチン誘発腸管粘膜傷害ラットモデルを用いた六君子湯, 半夏瀉心湯の小腸粘膜保護効果の検討2019

    • Author(s)
      銭谷昌弘,佐々木隆士,大植孝治
    • Organizer
      第61回日本小児血液・がん学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] シスプラチン誘発腸管粘膜傷害ラットモデルを用いた半夏瀉心湯の小腸粘膜保護効果の検討2019

    • Author(s)
      佐々木隆士,銭谷昌弘,大植孝治
    • Organizer
      第24回日本小児外科漢方研究会
    • Related Report
      2019 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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