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Functional analysis of KIAA1199 in skin wound healing

Research Project

Project/Area Number 16K11380
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionKeio University

Principal Investigator

ARAMAKI Noriko  慶應義塾大学, 医学部(信濃町), 講師 (80365311)

Co-Investigator(Kenkyū-buntansha) 貴志 和生  慶應義塾大学, 医学部(信濃町), 教授 (40224919)
下田 将之  慶應義塾大学, 医学部(信濃町), 准教授 (70383734)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsヒアルロン酸 / 創傷治癒 / 瘢痕 / KIAA1199 / 細胞外マトリックス / KIAA / ヒアルロン酸分解酵素
Outline of Final Research Achievements

In this study, we analyze the function of KIAA1199 in skin and cutaneous wounds by investigating the healing process of adult and fetal wounds using knockout mice of the new hyaluronan degrading enzyme KIAA1199. There have been no previous reports of functional analysis of KIAA1199 in the wound healing process, our data suggested that KIAA deficiency affects the wound healing process, especially the stage of scar formation. Since we have not conducted research on angiogenesis in this study, it is thought that future analysis is necessary, but it is expected to be applied to treatments such as scar management in the future.

Academic Significance and Societal Importance of the Research Achievements

難治性創傷や瘢痕は、形成外科分野での解決すべき臨床課題である。今回の我々の研究成果からKIAA1199が創傷治癒過程や瘢痕形成期に関与していることが示唆され、またその抑制が瘢痕形成の抑制につながる可能性が示された。今後研究を進めていくこと行くことで、将来的な臨床応用が期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Presentation (2 results)

  • [Presentation] ケロイド・肥厚性瘢痕の病態形成―細胞外マトリックスの関与について2018

    • Author(s)
      荒牧典子、貴志和生
    • Organizer
      第61回日本形成外科総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ケロイド・肥厚性瘢痕組織におけるKIAA1199の発現比較検討2017

    • Author(s)
      荒牧典子、岡部圭介、酒井成貴、貴志和生
    • Organizer
      第26回日本形成外科学会基礎学術集会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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