Crosstalk of Inflammation and Coagulation and the Role of Vasoactive Substances in DIC Pathology
| Project/Area Number |
16K11396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
KADOHIRA Yasuko
YAMADSA Shinya
ARAHATA Masahisa
MORISHITA Eriko
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | DIC / 播種性血管内凝固症候群 |
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| Outline of Final Research Achievements |
The essential features of DIC are marked coagulation activation and multiple microthrombi, which, when advanced, cause irreversible organ damage and bleeding symptoms. The development of appropriate diagnostic criteria and early intervention according to the disease state are necessary for improvement of prognosis. In our study using the DIC model, even if sufficient anticoagulation therapy is performed, the progression of DIC with organ damage caused by microcirculatory disturbance and endothelial disturbance is irreversible especially in the disease state with strong inflammation, and elements other than coagulation activation seem to be deeply involved in the disease state. Vasoactive substances are likely to affect the hemodynamics of DIC, but their significance is unclear. The significance of vasoactive substances in the DIC model will be continuously examined in future.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦では、癌と血栓性が二大死因である。血栓性には、心筋梗塞、脳梗塞、静脈血栓塞栓症（肺塞栓など）が含まれており致死的となる。そのため、血栓症の克服は、日本国民の健康寿命を延伸するための最重要課題の一つである。種々の血栓症の中でも、播種性血管内凝固症候群（DIC）は、「究極の血栓症」とも言える病態である。DICに対する病態解析の手法や治療法改善の考え方は、そのまま一般的な血栓症に応用可能である。
ラットを用いたDICモデルの作成は容易であり、このモデルを用いた研究は、広く血栓症全体の病態解析や治療法の改善に応用することができる。
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Report
(4 results)
Research Products
(114 results)
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[Journal Article] Thrombosis Prediction Based on Reference Ranges of Coagulation-Related Markers in Different Stages of Pregnancy.2017
Author(s)
Sekiya A, Hayashi T, Kadohira Y, Shibayama M, Tsuda T, Jin X, Nomoto H, Asakura H, Wada T, Ohtake S, Morishita E
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Journal Title
Clin Appl Thromb Hemost
Volume: 印刷中
Issue: 7
Pages: 844-850
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Causative genetic mutations for antithrombin deficiency and their clinical background among Japanese patients.2017
Author(s)
Sekiya A, Taniguchi F, Yamaguchi D, Kamijima S, Kaneko S, Katsu S, Hanamura M, Takata M, Nakano H, Asakura H, Ohtake S, Morishita E
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Journal Title
Int J Hematol
Volume: 105
Issue: 3
Pages: 287-294
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis.2017
Author(s)
Aota T, Wada H, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Usui M, Isaji S, Asakura H, Okamoto K, Katayama N.
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Journal Title
Clin Appl Thromb Hemost.
Volume: 印刷中
Issue: 6
Pages: 579-584
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gene analysis of six cases of congenital protein S deficiency and functional analysis of protein S mutations (A139V, C449F, R451Q, C475F, A525V and D599TfsTer13）2017
Author(s)
Taniguchi F, Morishita E, Sekiya A, Nomoto H, Katsu S, Kaneko S, Asakura H, Ohtake S
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Journal Title
Thromb Res
Volume: 151
Pages: 8-16
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The valuable diagnosis of DIC and pre-DIC and prediction of a poor outcome by the evaluation of diagnostic criteria for DIC in patients with hematopoietic injury established by the Japanese Society of Thrombosis and Hemostasis2016
Author(s)
Aota T, Wada H, Fujimoto N, Sugimoto K, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Kawasugi K, Madoiwa S, Asakura H, Katayama N
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Journal Title
Thromb Res
Volume: 147
Pages: 80-84
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 血液凝固検査の解釈2016
Author(s)
朝倉英策
Organizer
第34回日本血液学会北陸地方会
Place of Presentation
金沢市（石川県立中央病院）
Year and Date
2016-07-23
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