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Development of cerebral monitoring by the redox state of cytochrome aa3 for post-resuscitation encephalopathy

Research Project

Project/Area Number 16K11410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionKagoshima University

Principal Investigator

Kakihana Yasuyuki  鹿児島大学, 医歯学域医学系, 教授 (20264426)

Co-Investigator(Kenkyū-buntansha) 安田 智嗣  鹿児島大学, 医歯学域附属病院, 講師 (80437954)
山口 桂司  鹿児島大学, 医歯学域附属病院, 助教 (50377280)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords近赤外線時間分解分光法 / 蘇生後脳症 / 心停止 / 脳内酸素飽和度 / チトクロームaa3 / 散乱係数 / 心肺蘇生法 / 脳浮腫 / NIRS / TRS / cardiopulmonary arrest / encephalopathy / scattering coefficient / cerebral SO2 / MRI / 近赤外線分光法 / 心肺蘇生 / ROSC / 脳モニタリング / 救命 / モニタリング / 脳・神経
Outline of Final Research Achievements

The purpose of this study is to examine whether near infrared time-resolved spectroscopy (TRS) can detect acute changes after resuscitation and post-resuscitation encephalopathy onset, and aim to construct a new brain monitoring method. In this study, it was shown that by using two analysis methods (modified Beer-Lambert law and photon diffusion theory), information of cerebral oxygen saturation (cSO2) in the shallow and deep region of the brain enables to detect separately. On the other hand, the measurement of the scattering coefficient (us') or cytochrome oxidase (Cyt. ox) suggested the possibility of detecting the onset of cerebral edema which cannot be detected by cSO2. Based on the above, it was concluded that measurement of cSO2, us', and Cyt. ox using TRS at the bedside can monitor not only acute brain changes during resuscitation but also severe brain changes such as post-resuscitation encephalopathy onset over time.

Academic Significance and Societal Importance of the Research Achievements

心肺停止に対する迅速な心肺蘇生法と脳低体温療法の導入は、救命率向上と蘇生後脳症の軽減に大きく寄与しているが、それ以外の脳保護療法に関する明確な指針は確立していない。今回の研究結果より、TRSは蘇生直後の急性期変化だけでなく、蘇生数時間後に発症する蘇生後脳症をベッドサイドでリアルタイムにモニタリングできる可能性が示されたため、今後の脳保護療法の選択や導入時期に有用な情報を与えてくれるものと期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study.2018

    • Author(s)
      Kakihana Y, Kamikokuryo C, Furubeppu H, Madokoro Y, Futatsuki T, Miyamoto S, Haraura H, Hatanaka K, Eguchi T, Saitoh Y, Miura N, Suzuki H, Ueda Y, Yasuda T, Ito T.
    • Journal Title

      Adv Exp Med Biol

      Volume: 1072 Pages: 83-87

    • DOI

      10.1007/978-3-319-91287-5_14

    • ISBN
      9783319912851, 9783319912875
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 近赤外線分光法の新たな可能性を探るー危機的状況での必須な情報とは?ー2018

    • Author(s)
      垣花泰之
    • Organizer
      第21回日本光脳機能イメージング学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study2017

    • Author(s)
      Yasuyuki Kakihana
    • Organizer
      45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] THE POTENTIAL OF NEAR-INFRARED SPECTROSCOPY AS AN OXYGENATION INDEX OF PIVOTAL ORGANS AND TISSUE OXYGENATION IN CRITICALLY ILL PATIENTS2016

    • Author(s)
      垣花 泰之
    • Organizer
      第8回世界ショック学会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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