• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of Intestinal disorder and liver damage resulting from cardiac arrest

Research Project

Project/Area Number 16K11413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionSapporo Medical University

Principal Investigator

Harada Keisuke  札幌医科大学, 医学部, 講師 (00560004)

Co-Investigator(Kenkyū-buntansha) 上村 修二  札幌医科大学, 医学部, 講師 (10448607)
水口 徹  札幌医科大学, 保健医療学部, 教授 (30347174)
井上 弘行  札幌医科大学, 医学部, 助教 (30721568)
成松 英智  札幌医科大学, 医学部, 教授 (70295343)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心停止後症候群 / 経皮的心肺補助装置 / 肝不全 / 腸管障害 / 小型肝細胞 / 小型幹細胞
Outline of Final Research Achievements

We established a rat model of intestinal ischemic injury with post cardiopulmonary arrest syndrome. We also evaluated the damage of intestine and liver cells after cardiopulomonary resuscitation. The cell damage induced by extracorporeal pulmonary resuscitation, which were found in intestinal mucosa, but were not found in hepatic tissue.
The mechanism of intestinal dysfunction induced by the short term of resuscitation, the change of hemodynamics and brain hypothermia therapy might also correlated with reperfusion injury after the cardiopulmonary arrest.

Academic Significance and Societal Importance of the Research Achievements

院外心停止患者は極めて予後不良であり、また脳・心臓後遺症を併発する心停止後症候群患者の増加は社会問題である。我々はこれまでに、心肺脳蘇生法としての経皮的心肺補助(PCPS)を応用し、良好な治療成績を報告してきたが、蘇生後、下痢など消化器症状や、続発する肝障害を高率に経験した。これらは、心肺停止に伴う腸管虚血再潅流や、PCPS下での腸管血流の変化によって生じたと考えられ、最終的には肝不全から多臓器不全に至る“蘇生後腸管症候群”と定義される。このような病態について、ラット蘇生後腸管症候群モデルを確立し、病態解明を進めるとともに、救命戦略としての治療介入を探索することを目的に研究を行った。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (27 results)

All 2020 2019 2018 2017

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 9 results) Presentation (16 results)

  • [Journal Article] Prognostic Significance of the Difference Between Mixed and Jugular Venous Oxygen Saturation After Severe Traumatic Brain Injury: A Post Hoc Analysis of the Brain Hypothermia Study.2020

    • Author(s)
      Bunya N, Aisaka W, Miyata K, Narimatsu E, Yamashita S, Kuroda Y, Kobata H, Kaneko T, Fujita M, Dohi K, Oda Y, Maekawa T; B-HYPO Study Group.
    • Journal Title

      World Neurosurg.

      Volume: - Pages: e68-e74

    • DOI

      10.1016/j.wneu.2020.01.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elderly-onset acute necrotizing encephalopathy mimicking severe heat stroke: a case report and review of the literature.2019

    • Author(s)
      Odagiri A, Yamaoka A, Miyata K, Bunya N, Kasai T, Takeyama Y, Uemura S, Mikami T, Narimatsu E.
    • Journal Title

      Acute Med Surg.

      Volume: - Issue: 3 Pages: 316-320

    • DOI

      10.1002/ams2.418

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful use of veno-arterial extracorporeal membrane oxygenation for septic cardiomyopathy in a patient with pre-existing chronic heart failure.2019

    • Author(s)
      Wada K, Bunya N, Kakizaki R, Kasai T, Uemura S, Harada K, Narimatsu E.
    • Journal Title

      Acute Med Surg.

      Volume: - Issue: 3 Pages: 301-304

    • DOI

      10.1002/ams2.407

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prognostic value of agonal respiration in refractory cardiac arrest: a case series of non-shockable cardiac arrest successfully resuscitated through extracorporeal cardiopulmonary resuscitation.2019

    • Author(s)
      Bunya N, Wada K, Yamaoka A, Kakizaki R, Katayama Y, Kasai T, Kyan R, Murakami N, Kokubu N, Uemura S, Narimatsu E.
    • Journal Title

      Acute Med Surg.

      Volume: 6 Issue: 2 Pages: 197-200

    • DOI

      10.1002/ams2.398

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful use of vino-arterial extracorporeal membrane oxygenation for septic cardiomyopathy in a patient with pre-existing chronic heart failure2019

    • Author(s)
      Wada K, Bunya N, Kakizaki R, Kasai T, Uemura S, Harada K, Narimatsu E.
    • Journal Title

      Acute Med Surg.

      Volume: xx

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors for acute pancreatitis in patients with accidental hypothermia2019

    • Author(s)
      Inoue H, Uemura S, Harada K, Mizuno H, Bunya N, Nomura K, Kakizaki R, Narimatsu E.
    • Journal Title

      American Journal of Emergency Medicine

      Volume: 37 Issue: 2 Pages: 189-193

    • DOI

      10.1016/j.ajem.2018.05.008

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Takotsubo cardiomyopathy developed during rewarming of accidental hypothermia with extracorporeal membrane oxygenation.2019

    • Author(s)
      Kakizaki R, Bunya N, Uemura S, Odagiri A, Kasai T, Narimatsu E.
    • Journal Title

      Acute Med Surg.

      Volume: 6 Issue: 2 Pages: 201-205

    • DOI

      10.1002/ams2.399

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delayed retroperitoneal hemorrhage during veno-venous extracorporeal membrane oxygenation: a case report.2019

    • Author(s)
      Sugiura G, Bunya N, Yamaoka A, Okuda H, Saito M, Mizuno H, Inoue H, Narimatsu E.
    • Journal Title

      Acute Med Surg.

      Volume: 6 Issue: 2 Pages: 180-184

    • DOI

      10.1002/ams2.385

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful resuscitation for cardiac arrest due to severe accidental hypothermia accompanied by mandibular rigidity: a case of cold stiffening mimicking rigor mortis.2018

    • Author(s)
      Bunya N, Sawamot K, Kakizaki R, Wada K, Katayama Y, Mizuno H, Inoue H, Uemura S, Harada K, Narimatsu E.
    • Journal Title

      Int J Emerg Med.

      Volume: xx Pages: 46-46

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effectiveness of hybrid treatment for severe multiple trauma: a case of multiple trauma for damage control laparotomy and thoracic endovascular repair.2017

    • Author(s)
      Bunya N, Harada K, Kuroda Y, Toyohara T, Kubota N, Kakizaki R, Irifune H, Uemura S, Narimatsu E.
    • Journal Title

      Inl J Emerg Med.

      Volume: 10:5 Issue: 1 Pages: 1-5

    • DOI

      10.1186/s12245-017-0145-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] How to manage Tension gastrthorax: A case report of tension gastrothorax with multiple trauma due to traumatic diaphragmatic rupture.2017

    • Author(s)
      Bunya N, Sawamoto K, Uemura S, Toyohara T, Yukino M, Kyan R, Miyata K, Irifune H, Harada K, Narimatsu E.
    • Journal Title

      Inl J Emerg Med.

      Volume: 10:4 Issue: 1 Pages: 1-4

    • DOI

      10.1186/s12245-017-0131-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ECPR下に施行した緊急開腹手術症例の検討2019

    • Author(s)
      原田敬介, 石井雅之, 西舘敏彦, 沖田憲司, 成松英智, 竹政伊知朗
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 体外膵液循環を確立した膵損傷の治療経験2019

    • Author(s)
      原田敬介, 文屋尚史, 喜屋武玲子, 成松英智
    • Organizer
      第33回日本外傷学会総会・定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 体表冷却ラットを用いた低体温に起因する膵傷害発現の病態解明2019

    • Author(s)
      井上弘行, 原田敬介, 文屋尚史, 上村修二, 成松英智
    • Organizer
      第47回日本救急医学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 重症急性胆管炎においてVA-ECMO導入下でERBDを施行し救命した1症例2019

    • Author(s)
      加藤三四郎, 文屋尚史, 原田敬介, 佐藤昌太, 柿崎隆一郎, 井上弘行, 上村修二, 成松英智
    • Organizer
      第46回日本集中治療医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 当院における敗血症性ショックに対するVA-ECMO導入基準の検討2019

    • Author(s)
      文屋尚史, 柿崎隆一郎, 加藤三四郎, 上村修二, 原田敬介, 成松英智
    • Organizer
      第46回日本集中治療医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 敗血症性ショックに伴うNOMIに対する治療戦略~PCPSとDLの位置付け2018

    • Author(s)
      原田敬介, 柿崎隆一郎, 文屋尚史, 喜屋武玲子, 水野浩利, 井上弘行, 上村修二, 成松英智
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 偶発性低体温症における急性膵炎のリスク因子:2018

    • Author(s)
      井上弘行, 上村修二, 原田敬介, 文屋尚史, 野村和史, 成松英智
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 出血合併症を伴うECPR症例に対する治療戦略の検討2018

    • Author(s)
      佐藤弘樹, 文屋尚史, 村上直人, 上村修二, 國分宣明, 原田敬介, 成松英智
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 来院時神経学的所見はECPR導入患者の予後良好予測因子である2018

    • Author(s)
      加藤三四郎, 文屋尚史, 柿崎隆一郎, 井上弘行, 上村修二, 宮田圭, 國分宣明, 原田敬介, 成松英智
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ECPR症例において病院到着後のアドレナリン投与は神経学的予後改善に寄与しない2018

    • Author(s)
      文屋尚史, 上村修二, 柿崎隆一郎, 井上弘行, 宮田圭, 國分宣明, 原田敬介, 成松英智
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ECPR症例に非閉塞性腸管虚血を来した1例2018

    • Author(s)
      加藤三四郎, 文屋尚史, 上村修二, 原田敬介, 佐藤昌太, 國分宣明, 成松英智
    • Organizer
      第42回北海道救急医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 腹腔内出血を合併したECPR症例に対する治療戦略の検討2018

    • Author(s)
      佐藤弘樹, 文屋尚史, 村上直人, 上村修二, 國分宣明, 宮田圭, 原田敬介, 成松英智
    • Organizer
      第42回北海道救急医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 院外心停止症例において死戦期呼吸はECPR導入患者の予後良好の予測因子である2018

    • Author(s)
      文屋 尚史, 沢本 圭悟, 上村 修二, 原田 敬介, 成松 英智
    • Organizer
      第45回日本集中治療医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 敗血症による高度の心機能障害に対しECMOを導入し救命した1例2017

    • Author(s)
      和田健志郎, 文屋尚史, 喜屋武玲子, 原田敬介, 成松英智
    • Organizer
      第45回日本救急医学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 敗血症による高度の心機能障害に対しECMOを導入し救命した1例2017

    • Author(s)
      和田健志郎, 文屋尚史, 喜屋武玲子, 原田敬介, 成松英智
    • Organizer
      第1回日本集中治療医学会北海道支部学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当院におけるVeno-arterio extracorporeal membrane oxygenationの使用経験2017

    • Author(s)
      文屋尚史, 和田健志郎, 山岡歩, 喜屋武玲子, 上村修二, 原田敬介, 成松英智
    • Organizer
      第1回日本集中治療医学会北海道支部学術集会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi