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Mechanism of blood pressure regulation by molecular hydrogen in chronic kiney disease

Research Project

Project/Area Number 16K11420
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionKeio University

Principal Investigator

Suzuki Masaru  慶應義塾大学, 先導研究センター, 特任教授 (70265916)

Co-Investigator(Kenkyū-buntansha) 佐野 元昭  慶應義塾大学, 医学部(信濃町), 准教授 (30265798)
Research Collaborator TAMURA Tomoyoshi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords分子状水素 / 水素ガス / 保存期腎不全 / 腎性高血圧 / 高血圧 / 慢性腎不全 / 神経液性因子 / 救急医学 / 保存期慢性腎不全 / 水素医学 / 循環器・高血圧
Outline of Final Research Achievements

Hydrogen gas inhalation initiated immediately after partial nephrectomy was not effective in improving renal function or preventing an elevation in blood pressure in the acute phase. However, blood pressure showed a tendency to be lowered with repeated intermittent inhalation of the hydrogen gas in subacute phase. The result of the frequency analysis indicated that hydrogen gas exerted an antihypertensive effect independent of the control of the sympathetic nerve activity. A tendency of lowered blood pressure was observed even when hydrogen gas inhalation was initiated 3 weeks after the partial nephrectomy. In the hydrogen group, plasma renin activity, angiotensin II, aldosterone, and urinary norepinephrine tended to decrease and urinary sodium excretion tended to increase. It was suggested that intermittent repeated inhalation of hydrogen gas shows an antihypertensive effect through the inhibition of neurohumoral factors in a remnant kidney model.

Academic Significance and Societal Importance of the Research Achievements

腎機能悪化の懸念からアンギオテンシン変換酵素阻害薬やアンギオテンシンⅡ阻害薬が使用し難い保存機腎不全患者において腎機能に影響せず降圧効果を有するため、水素ガス吸入療法が腎性高血圧の新規治療となる可能性がある。高血圧自然発症ラットを用いた検討では保存期腎不全と比較して降圧効果は弱く、水素ガスの効果は高血圧の病態に依存する可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2017

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] Hydrogen gas inhalation inhibits progression to the “irreversible” stage of shock after severe hemorrhage in rats2017

    • Author(s)
      Matsuoka Tadashi、Suzuki Masaru、Sano Motoaki、Hayashida Kei、Tamura Tomoyoshi、Homma Koichiro、Fukuda Keiichi、Sasaki Junichi
    • Journal Title

      Journal of Trauma and Acute Care Surgery

      Volume: 83 Issue: 3 Pages: 469-475

    • DOI

      10.1097/ta.0000000000001620

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction ― First Pilot Study in Humans ―2017

    • Author(s)
      Katsumata Y, Sano F, Abe T, Tamura T, Fujisawa T, Shiraishi Y, Kohsaka S, Ueda I, Homma K, Suzuki M, Okuda S, Maekawa Y, Kobayashi E, Hori S, Sasaki J, Fukuda K, Sano M.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 7 Pages: 940-947

    • DOI

      10.1253/circj.CJ-17-0105

    • NAID

      130006887049

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial2017

    • Author(s)
      Tamura Tomoyoshi、Hayashida Kei、Sano Motoaki、Onuki Shuko、Suzuki Masaru
    • Journal Title

      Trials

      Volume: 18 Issue: 1 Pages: 1870-1873

    • DOI

      10.1186/s13063-017-2246-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Promising novel therapy with hydrogen gas for emergency and critical care medicine2017

    • Author(s)
      Sano Motoaki、Suzuki Masaru、Homma Koichiro、Hayashida Kei、Tamura Tomoyoshi、Matsuoka Tadashi、Katsumata Yoshinori、Onuki Shuko、Sasaki Junichi
    • Journal Title

      Acute Medicine & Surgery

      Volume: 5 Issue: 2 Pages: 113-118

    • DOI

      10.1002/ams2.320

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 水素ガス吸入システムの考案と 院外心停止後患者への応用2017

    • Author(s)
      多村知剛、林田 敬、鈴木 昌、佐野元昭、堀 進悟
    • Organizer
      第44回日本集中治療医学会学術集会. 札幌市(ロイトン札幌)
    • Related Report
      2017 Research-status Report
  • [Presentation] Hydrogen Gas Inhalation Reduced Adverse Left Ventricular Remodeling after the Percutaneous Coronary Intervention for ST-elevated Myocardial Infarction.2017

    • Author(s)
      Katsumata Y、Sano F、Abe T、Tamura T、Fujisawa T、Shiraishi Y、Kohsaka S、Ueda I、Homma K、Suzuki M、Okuda S、Maekawa Y、Kobayashi E、Hori S、Sasaki J、Fukuda K、Sano M
    • Organizer
      第81回日本循環器学会学術集会. 金沢(石川県立音楽堂他)
    • Related Report
      2017 Research-status Report
  • [Presentation] 心停止後症候群に対する水素ガス吸入療法~ガイドラインで推奨される治療開発を目指して~2017

    • Author(s)
      鈴木 昌、多村知剛、佐野元昭
    • Organizer
      第20回日本臨床救急医学会総会・学術集会.東京(東京ビックサイト)
    • Related Report
      2017 Research-status Report
  • [Presentation] 心停止後症候群に対する水素ガス吸入療法の研究プロトコル紹介2017

    • Author(s)
      鈴木 昌、多村知剛、佐野元昭
    • Organizer
      第7回日本分子状水素医学生物学会年会.名古屋(ホテル名古屋ガーデンパレス)
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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