Topdown signaling from the motor cortex for pain inhibition
| Project/Area Number |
16K11454
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
KURAMOTO Eriko 鹿児島大学, 医歯学域歯学系, 助教 (60467470)
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| Co-Investigator(Kenkyū-buntansha) |
桑木 共之 鹿児島大学, 医歯学域医学系, 教授 (80205260)
齋藤 充 鹿児島大学, 医歯学域歯学系, 教授 (50347770)
柏谷 英樹 鹿児島大学, 医歯学域医学系, 講師 (70328376)
大野 幸 鹿児島大学, 医歯学域鹿児島大学病院, 助教 (00535693)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 三叉神経痛 / 大脳皮質 / 運動野 / 帯状野 / 中脳水道周囲灰白質 / 前頭眼野 / 視床 内側下核 / 大脳皮質運動野 / 痛覚抑制 / 三叉神経系 / 痛覚 / 前頭前野 |
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| Outline of Final Research Achievements |
As a treatment for trigeminal neuralgia, it is recently reported that electrical stimulation of the motor cortical area is effective. We aimed to elucidate anatomically and behaviorally the mechanism of pain suppression by electrical stimulation of the motor cortex. Tracing experiments with viral vectors revealed that axons from the motor cortex were mostly distributed in the sensory, cingulate, and orbitofrontal cortices, but not in the periaqueductal gray. Therefore, it was suggested that the pathway of motor cortex → cingulate cortex → periaqueductal gray → locus coeruleus exerts a pain suppressive function. In addition, since the orbitofrontal cortical area strongly projects to the submedial thalamic nucleus, which is related to pain suppression, it is suggested that the pathway of motor area → orbitofrontal area → submedial thalamic nucleus may also have an effect on pain suppression.
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| Academic Significance and Societal Importance of the Research Achievements |
三叉神経痛の中には、薬物や外科的療法により治療できない症例が少なからず存在する。こうした難治性の三叉神経痛の治療法として、大脳皮質 運動野の電気刺激療法がおこなわれて、一定の治療効果が得られている。しかしながら、運動野を刺激することで、なぜ、痛覚抑制の効果が得られるのか、そのメカニズムはほとんど明らかにされていない。
このメカニズムの詳細を明らかにすることができれば、より効果的な治療方法への改善や、より効果的で侵襲性の低い治療法の開発の糸口にすることが可能である。三叉神経痛だけでなく、難治性の神経陰性疼痛の治療へ、広く適応できる可能性が高く、社会的意義が大きい。
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] Inhibition of GluR Current in Microvilli of Sensory Neurons via Na(+)-Microdomain Coupling among GluR, HCN channel and Na(+)/K(+) Pump.2018
Author(s)
Kawasaki Y, Saito M, Won J, Bae JY, Sato H, Toyoda H, Kuramoto E, Kogo M, Tanaka T, Kaneko T, Oh SB, Bae YC, Kang Y.
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Journal Title
Front. Cell. Neurosci.
Volume: 印刷中
Pages: 113-113
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A distinct functional distribution of α and γ motoneurons in the rat trigeminal motor nucleus.2017
Author(s)
Morita-Isogai, Y., Sato, H., Saito, M., Kuramoto, E., Yin, D., Kaneko, T., Yamashiro, T., Takada, K., Oh, S.B., Toyoda, H., & Kang, Y.
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Journal Title
Brain Structure and Function
Volume: -
Issue: 7
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Distinct functional and morphological properties of the frontal and parietal layer 5 corticothalamic pathways.2020
Author(s)
Eriko Kuramoto, Hajnelka Bokor, Nora Hadinger, Emilia Bosz, Boglarka Toth, Csaba David, Gergely Komlosi, Gordon Shepherd, Naoki Yamawaki, Tetsuya Goto, Laszlo Acsady.
Organizer
Gordon Research Conference, "Thalamocortical Interaction"
Related Report
Int'l Joint Research
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