| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Mfa1 fimbrial forms are composed of five proteins of Mfa1-Mfa5, but there is limited information about their polymerization mechanisms and functions. Here, we evaluated the localization and function of Mfa5 in biogenesis of Mfa1 fimbriae. As a result, Mfa5 was necessary for expression of intact Mfa1 fimbriae on the cells surface. Mfa5 may be localized at the tip of the fimbrial shaft. Moreover, Mfa5 function required T9SS-mediated translocation across the outer membrane, and subsequent incorporation into fibers.
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