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Study of neuronal activity, a molecular basis and a behavioral change related to chemoreceptor-mediated nausea and emesis.

Research Project

Project/Area Number 16K11471
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionHokkaido University

Principal Investigator

FUNAHASHI MAKOTO  北海道大学, 歯学研究院, 教授 (80221555)

Co-Investigator(Kenkyū-buntansha) 久留 和成  北海道大学, 歯学研究院, 助教 (00592081)
前澤 仁志  北海道大学, 歯学研究院, 助教 (80567727)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords悪心 / 嘔吐 / 最後野 / 迷走神経 / 化学受容器 / ラット / 化学受容性 / エメチン / トラネキサム酸 / セロトニン受容体 / 摂食行動 / 催吐薬 / 味覚嫌悪学習 / 飲水行動
Outline of Final Research Achievements

As an intracellular mechanism for glucose responsiveness of the area postrema neurons, it was found that the ATP-dependent potassium channel (KATP channel) was closed by an increase in the extracellular glucose concentration, leading to the generation of depolarization and action-potentials. The glucose-responsive neurons were suggested to be H-channel non-expressing cells. The neuronal activity of the area postrema is crucial for the inducing mechanism of emetine-induced nausea, and it was also found that depolarization occurs in the central neurons including the nucleus tractus solitarius, the central nucleus of amygdala, the bed nucleus. It became clear that the memory recall of the taste aversion did not involve the activity of the nervous system related to a nausea induction.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は化学受容性悪心・嘔吐の中枢機序について,延髄最後野のニューロン活動および連携する中枢ニューロン活動に着目して実験を行い,これまで不明であった点を明らかにして新たな概念を樹立するための基礎となる知見を得たものであり,その学術的意義は深い。また,抗がん剤の副作用による悪心・嘔吐の機序解明と新たな制吐方法の創出や制吐薬の開発につながる点では社会的意義が深い。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Premotoneuronal inputs to early developing trigeminal motoneurons.2017

    • Author(s)
      Matsuda K, Nakamura S, Nonaka M, Mochizuki A, Nakayama K, Iijima T, Yokoyama A, Funahashi M, Inoue T.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 59 Pages: 96-103

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological analysis of neurons in the area postrema.2017

    • Author(s)
      Funahashi M
    • Journal Title

      Hokkaido J. Dent. Sci.

      Volume: 38 Pages: 63-67

    • NAID

      120006360111

    • Related Report
      2017 Research-status Report
  • [Journal Article] Movement-related cortical magnetic fields associated with self-paced tongue protrusion in humans2016

    • Author(s)
      Maezawa H, Oguma H, Hirai Y, Hisadome K, Shiraishi H, Funahashi M
    • Journal Title

      Neuroscience Research

      Volume: 117 Pages: 22-27

    • DOI

      10.1016/j.neures.2016.11.010

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of intraperitoneally administered L-histidine on food intake, taste, and visceral sensation in rats2016

    • Author(s)
      Okusha Y, Hirai Y, Maezawa H, Hisadome K, Inoue N, Yamazaki Y, Funahashi M.
    • Journal Title

      The Journal of Physiological Sciences

      Volume: - Issue: 4 Pages: 467-474

    • DOI

      10.1007/s12576-016-0476-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of vagotomy and area postrema lesion on induction of emesis by emetine.2019

    • Author(s)
      Makoto Funahashi, Yoshiyuki Hirai,Mayu Fujita,Kazunari Hisadome, HItoshi Maezawa
    • Organizer
      FAOPS&第96回日本生理学会合同大会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エメチン誘発の悪心に対する迷走神経切除と最後野損傷の影響2018

    • Author(s)
      舩橋誠,平井喜幸,藤田麻由,久留和成,前澤仁志
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] トラネキサム酸の悪心・嘔吐誘発機序の解析2018

    • Author(s)
      藤田麻由,久留和成,平井喜幸,前澤仁志,舩橋誠
    • Organizer
      第98回北海道医学大会生理系分科会(日本生理学会北海道地方会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 絶食ラットの脳幹部における高血糖の影響2017

    • Author(s)
      播磨美樹,久留和成,平井喜幸,北川善政,舩橋誠
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市・アクトシティ浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] エメチンの催吐作用とその中枢機序2017

    • Author(s)
      佐藤孝紀, 久留和成, 平井喜幸, 舩橋誠
    • Organizer
      歯科基礎医学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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