The role of PRIP in the Regulation of Insulin Signaling
Project/Area Number |
16K11479
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional basic dentistry
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Research Institution | Kyushu University |
Principal Investigator |
Gao Jing 九州大学, 歯学研究院, 助教 (40585882)
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | PRIP / インスリンシグナル経路 / インスリンシグナリング / インスリン受容体 / AKT / IRS / Akt / インスリンシグナル伝達 / リン酸化 |
Outline of Final Research Achievements |
In the present study, we have elucidated the role of a signaling molecule PRIP in the insulin signaling pathway. It was found that PRIP suppressed the internalization of insulin receptor (IR) in adipocytes and maintained the appropriate expression level of IR in the cell membrane. We also found that PRIP promoted the dephosphorylation of serine/threonine phosphorylation of the insulin receptor substrate (IRS) -1, which is a major mechanism involved in the negative regulation of the insulin signaling pathway. These results suggest that PRIP plays an important role in the regulation of insulin signal pathway.
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Academic Significance and Societal Importance of the Research Achievements |
肥満や糖尿病などのメタボリック症候群は健康寿命の延伸と密接に関わり、その軽減と解消が課題となる。また、メタボリック症候群は歯周病の増悪とも密接に関わることが明らかにされ、歯学からの情報発信も臨床基礎を問わずに期待されるようになった。しかし、発症基盤であるインスリンシグナル伝達経路の異常の分子メカニズムについては、未だ不明な点も多い。本研究によりインスリンシグナル伝達経路の調節機構に新規分子P R I Pを登場させ、その分子メカニズムの一つが解明された。本領域疾患の病態解明、治療方法の確立や創薬技術の発展に貢献することが期待できる。
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] GLP-1 signaling is required for improvement of glucose tolerance by osteocalcin. J. Endocrinol.2020
Author(s)
Mizokami, A., Mukai, S., Gao, J., Kawakubo-Yasukochi, T., Otani, T., Takeuchi, H., Jimi, E., Hirata, M.
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Journal Title
Journal of Endocrinology
Volume: 244
Issue: 2
Pages: 285-296
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Bif‐1/Endophilin B1/SH3GLB1 regulates bone homeostasis2019
Author(s)
Touyama Kenya、Khan Masud、Aoki Kazuhiro、Matsuda Miho、Hiura Fumitaka、Takakura Nana、Matsubara Takuma、Harada Yui、Hirohashi Yuna、Tamura Yukihiko、Gao Jing、Mori Kayo、Kokabu Shoichiro、Yasuda Hisataka、Fujita Yuko、Watanabe Koji、Takahashi Yoshinori、Maki Kenshi、Jimi Eijiro
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Journal Title
Journal of Cellular Biochemistry
Volume: 120
Issue: 11
Pages: 18793-18804
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Differential role of SNAP-25 phosphorylation by protein kinases A and C in the regulation of SNARE complex formation and exocytosis in PC12 cells2016
Author(s)
Gao, J., Hirata, Makiko, Mizokami, A., Zhao, J., Takahashi, I., Takeuchi, H. and Hirata, Masato
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Journal Title
Cell. Signal.
Volume: 28
Issue: 5
Pages: 425-437
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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