| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In the present study, we have elucidated the role of a signaling molecule PRIP in the insulin signaling pathway. It was found that PRIP suppressed the internalization of insulin receptor (IR) in adipocytes and maintained the appropriate expression level of IR in the cell membrane. We also found that PRIP promoted the dephosphorylation of serine/threonine phosphorylation of the insulin receptor substrate (IRS) -1, which is a major mechanism involved in the negative regulation of the insulin signaling pathway. These results suggest that PRIP plays an important role in the regulation of insulin signal pathway.
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