Molecular-based mechanism underlying oral ulcerative mucositis following anti-cancer drugs
| Project/Area Number |
16K11483
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
Ono Kentaro 九州歯科大学, 歯学部, 教授 (40316154)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
人見 涼露 九州歯科大学, 歯学部, 講師 (70548924)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 口内炎 / 疼痛 / 抗癌薬 / 三叉神経節 / プロスタグランジン / TRPV1 / TRPA1 / TRPV4 / 口内炎疼痛 / 5-FU / シスプラチン / TRPチャネル / 細菌浸潤 / 三叉神経節ニューロン / 唾液 / 鎮痛薬 / 細菌感染 / 神経科学 / 麻酔 |
|---|
| Outline of Final Research Achievements |
The anti-cancer drug 5-fluorouracil-received oral ulcerative mucositis model of rats showed severe mucositis due to massive bacterial infection in the ulcerative region following leucopenia. Bacterial toxins excited pain-related nerves via activation of nociceptive TRP channels. Other oral ulcerative mucositis models by mechanical injury or another anti-cancer drug cisplatin demonstrated different molecular mechanism underlying oral mucositis-induced pain. The Japanese herbal medicine, Hangeshashinto, has been reported to improve oral mucositis in cancer patients. In the 5-fluorouracil-received oral ulcerative mucositis model, the traditional drug elicited anti-nociceptive effect on pain by shogaols at ingredient level.
|
| Academic Significance and Societal Importance of the Research Achievements |
癌治療患者における激しい疼痛を伴う口内炎の発症は、臨床上大きな問題となっていたものの、その発症メカニズムは不明であった。本研究成果にて、抗癌剤による全身的な影響が口内炎の症状を増悪させ、特定の侵害受容TRPチャネルを介して痛みを生じていることが明らかとなった。口内炎の発症原因や抗癌剤の種類によって病態やTRPチャネルの種類が異なっていたため、患者によってより効果的な治療法を選択する必要があることが示唆される。また、臨床で使用される漢方薬の西洋科学的エビデンスを提供できたと考えている。
|
Report
(4 results)
Research Products
(47 results)
-
-
-
-
-
-
-
-
[Journal Article] Prostanoid-dependent spontaneous pain and PAR2-dependent mechanical allodynia following oral mucosal trauma: Involvement of TRPV1, TRPA1, and TRPV42017
Author(s)
Misa Ito, Kentaro Ono, Suzuro Hitomi, Tomotaka Nodai, Teppei Sago, Kiichiro Yamaguchi, Nozomu Harano, Kaori Gunjigake, Ryuji Hosokawa, Tatsuo Kawamoto and Kiyotoshi Inenaga
-
Journal Title
Molecular Pain
Volume: 13
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na+ channels.2017
Author(s)
Hitomi, S., Ono, K., Terawaki, K., Matsumoto, C., Mizuno, K., Yamaguchi, K., Imai, R., Omiya, Y., Hattori, T., Kase, Y., Inenaga, K.
-
Journal Title
Pharmacological Research
Volume: 117
Pages: 288-302
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Hitomi, S., Ono, K., Ujihara, I., Terawaki, K., Matsumoto, C., Omiya, Y., Inenaga, K.2017
Author(s)
Hitomi, S., Ono, K., Ujihara, I., Terawaki, K., Matsumoto, C., Omiya, Y., Inenaga, K.
Organizer
Oral neuroscience
Related Report
Int'l Joint Research
-
[Presentation] Oral ulcerative mucositis induces pain via endothelin receptors.2017
Author(s)
Nodai, T., Hitomi, S., Masaki, C., Ito, M., Hosokawa, R., Ono, K. and Inenaga, K.
Organizer
アジア太平洋国際カンファレンス
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
