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Research in the excitatory synaptic transmission during critical period of feeding

Research Project

Project/Area Number 16K11488
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

Nakamura Shiro  昭和大学, 歯学部, 准教授 (60384187)

Co-Investigator(Kenkyū-buntansha) 井上 富雄  昭和大学, 歯学部, 教授 (70184760)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords生後発達 / 摂食行動 / 閉口筋運動ニューロン / シナプス伝達 / グルタミン酸性受容体 / 開口筋運動ニューロン / 顎運動 / 咀嚼筋支配運動ニューロン / グルタミン酸受容体 / 臨界期 / 咀嚼 / 吸啜 / 三叉神経運動ニューロン / 神経科学 / 生理学 / 興奮性シナプス伝達
Outline of Final Research Achievements

We electrophysiologically investigated the developmental nature of glutamatergic synaptic transmission to the jaw-closing and jaw-opening motoneurons to elucidate the role of glutamatergic receptor functions in the regulation of feeding. The synaptic inputs mediated by NMDA receptors containing NR2A and NR2B subunits to the jaw-closing motoneurons decreased with postnatal age. In contrast, there were no differences of NMDA receptor-mediated synaptic inputs to the jaw-opening motoneurons throughout the postnatal period. These results suggest that the NMDA receptor-mediated synaptic inputs alter during postnatal period, which may contribute to the developmental transition of feeding behavior from suckling to mastication.

Academic Significance and Societal Importance of the Research Achievements

本研究で明らかとなった、顎筋運動ニューロンにおけるグルタミン酸性シナプス伝達の生後発育変化は、吸啜から咀嚼への転換に重要な役割を果たしている可能性が考えられる。今回の基礎データは、摂食行動の臨界期制御機構の一端が明らかになっただけでなく、自閉症等の発達障害児で問題となる摂食障害の発症機序の解明にもつながり、歯科医学の分野だけでなく小児医学・生涯発達学などの多くの分野に貢献することができる。さらにNMDA受容体サブユニットをターゲットとした摂食障害の治療法開発につながるという波及効果も期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (69 results)

All 2019 2018 2017 2016 Other

All Journal Article (17 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 16 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (49 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Book (2 results) Remarks (1 results)

  • [Journal Article] 5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses therough Src kinase in the dendrites of rat jaw-closing motoneurons.2019

    • Author(s)
      Dantsuji M, Nakamura S, Nakayam, K, Mochizuki A, Park SK, Bae YC, Ozeki M, Inoue T.
    • Journal Title

      J. Physiol.

      Volume: 印刷中 Issue: 9 Pages: 2565-2589

    • DOI

      10.1113/jp275440

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serotonin1B receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons.2019

    • Author(s)
      Nagata A, Nakayama K, Nakamura S, Mochizuki A, Gemba C, Aoki R, Dantsuji M, Maki K, Inoue T.
    • Journal Title

      Brain Res Bull.

      Volume: 149 Pages: 260-267

    • DOI

      10.1016/j.brainresbull.2019.05.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High molecular weight amyloid β1‐42 oligomers induce neurotoxicity via plasma membrane damage2019

    • Author(s)
      Yasumoto Taro、Takamura Yusaku、Tsuji Mayumi、Watanabe‐Nakayama Takahiro、Imamura Keiko、Inoue Haruhisa、Nakamura Shiro、Inoue Tomio、Kimura Atsushi、Yano Satoshi、Nishijo Hisao、Kiuchi Yuji、Teplow David B.、Ono Kenjiro
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 8 Pages: 9220-9234

    • DOI

      10.1096/fj.201900604r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhancement of swallowing motor activity by the ACE inhibitor imidapril in an arterially perfused rat preparation.2019

    • Author(s)
      Moriya T, Nakayama K, Nakamura S, Mochizuki A, Ofuji T, Shirota T, Inoue T.
    • Journal Title

      Eur J Pharmacol.

      Volume: 861 Pages: 172601-172601

    • DOI

      10.1016/j.ejphar.2019.172601

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Experimental Study on Involvement of the Central Nervous System in Inferior Alveolar Nerve Damage-Associated Hyperalgesia of the Mental Region2018

    • Author(s)
      Kiyomoto Masaaki、Shirota Tatsuo、Moriya Takashi、Sato Hitoshi、Nakamura Shiro、Inoue Tomio
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 76 Issue: 10 Pages: 2089.e1-2089.e8

    • DOI

      10.1016/j.joms.2018.06.021

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Generation of orthotopically functional salivary gland from embryonic stem cells2018

    • Author(s)
      Tanaka Junichi、Ogawa Miho、Hojo Hironori、Kawashima Yusuke、Mabuchi Yo、Hata Kenji、Nakamura Shiro、Yasuhara Rika、Takamatsu Koki、Irie Tarou、Fukada Toshiyuki、Sakai Takayoshi、Inoue Tomio、Nishimura Riko、Ohara Osamu、Saito Ichiro、Ohba Shinsuke、Tsuji Takashi、Mishima Kenji
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4216-4216

    • DOI

      10.1038/s41467-018-06469-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of orexin in lipid accumulation in the liver2018

    • Author(s)
      Mochizuki Ayako、Nakayama Kiyomi、Nakamura Shiro、Dantsuji Masanori、Kamijo Ryutaro、Shioda Seiji、Sakurai Takeshi、Ozeki Masahiko、Inoue Tomio
    • Journal Title

      Journal of Oral Biosciences

      Volume: 60 Issue: 3 Pages: 76-82

    • DOI

      10.1016/j.job.2018.07.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Confocal calcium imaging analysis of respiratory-related burst activity in the parafacial region.2018

    • Author(s)
      Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T.
    • Journal Title

      Brain Res Bull.

      Volume: 139 Pages: 16-20

    • DOI

      10.1016/j.brainresbull.2018.01.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Premotoneuronal inputs to early developing trigeminal motoneurons2017

    • Author(s)
      Matsuda K, Nakamura S, Nonaka M, Mochizuki A, Nakayama K, Iijima T, Yokoyama A, Funahashi M, Inoue T
    • Journal Title

      Journal of Oral Biosciences

      Volume: 印刷中 Issue: 2 Pages: 96-103

    • DOI

      10.1016/j.job.2017.01.003

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus2017

    • Author(s)
      Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Satoh F, Kawakami H, Takahashi K, Inoue T.
    • Journal Title

      Neuroscience

      Volume: 358 Pages: 211-226

    • DOI

      10.1016/j.neuroscience.2017.06.035

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Central Neural Mechanisms Involved in the Control of Jaw Movement during Postnatal Development2017

    • Author(s)
      NAKAMURA Shiro、NAGATA Shoko、NONAKA Mutsumi、NISHIMURA Akiko、NAGOYA Kouta、DANTSUJI Masanori、NAKAYAMA Kiyomi、MOCHIZUKI Ayako、IIJIMA Takehiko、OZEKI Masahiko、YAMAMOTO Matsuo、INOUE Tomio
    • Journal Title

      The Showa University Journal of Medical Sciences

      Volume: 29 Issue: 3 Pages: 221-229

    • DOI

      10.15369/sujms.29.221

    • NAID

      130006219349

    • ISSN
      0915-6380, 2185-0968
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coordinated control of the tongue during suckling-like activity and respiration2017

    • Author(s)
      Inoue T, Nakayama K, Ihara Y, Tachikawa S, Nakamura S, Mochizuki A, Takahashi K, Iijima T
    • Journal Title

      Journal of Oral Science

      Volume: 59 Issue: 2 Pages: 183-188

    • DOI

      10.2334/josnusd.16-0850

    • NAID

      130006882397

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 咀嚼の運動制御機構2017

    • Author(s)
      井上富雄,中山希世美,中村史朗
    • Journal Title

      Clinical Neuroscience

      Volume: 35 Pages: 689-692

    • Related Report
      2017 Research-status Report
  • [Journal Article] Continuous monitoring of caspase-3 activation induced by propofol in developing mouse brain.2016

    • Author(s)
      Konno A, Nishimura A, Nakayama S, Mochizuki A, Yamada A, Kamijo R, Inoue T, Iijima T
    • Journal Title

      Int J Dev Neurosci

      Volume: 51 Issue: 1 Pages: 42-49

    • DOI

      10.1016/j.ijdevneu.2016.04.007

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Postnatal changes in glutamatergic inputs of jaw-closing motoneuron dendrites2016

    • Author(s)
      Nagata S, Nakamura S, Nakayama K, Mochizuki A, Yamamoto M, Inoue T
    • Journal Title

      Brain Res Bull

      Volume: 127 Pages: 47-55

    • DOI

      10.1016/j.brainresbull.2016.08.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice2016

    • Author(s)
      Ikawa Y, Mochizuki A, Katayama K, Kato T, Ikeda M, Abe Y, Nakamura S, Nakayama K, Wakabayashi N, Baba K, Inoue T
    • Journal Title

      Neurosci Res

      Volume: 113 Pages: 48-55

    • DOI

      10.1016/j.neures.2016.07.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coordinated Respiratory Motor Activity in Nerves Innervating the Upper Airway Muscles in Rats2016

    • Author(s)
      Tachikawa S, Nakayama K, Nakamura S, Mochizuki A, Iijima T, Inoue T
    • Journal Title

      PLoS One

      Volume: 11 Issue: 11 Pages: e0166436-e0166436

    • DOI

      10.1371/journal.pone.0166436

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 除脳ラット動脈灌流標本を用いた咀嚼様リズム神経活動の誘発2019

    • Author(s)
      大藤拓生, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 井上富雄
    • Organizer
      日本顎口腔機能学会 第63回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] erotonin1b receptor mediated presynaptic inhibition of jaw closing motoneurons2019

    • Author(s)
      Nakayama K, Nagata A, Nakamura S, Mochizuki A, Dantsuji M, Maki K, Inoue T
    • Organizer
      Society for Neuroscience 49th annual meeting
    • Related Report
      2019 Annual Research Report
  • [Presentation] Orexin modulates electrophysiological properties of Phox2b neurons located around trigeminal motor nucleus2019

    • Author(s)
      Nagoya K, Nakamura S, Tsujimura T, Inoue M, Inoue T
    • Organizer
      Society for Neuroscience 49th annual meeting
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス咬筋の筋活動に対するSSRIの影響2019

    • Author(s)
      望月文子,池田美菜子,中村史朗,中山希世美,壇辻昌典,加藤隆史,馬場一美,井上富雄
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 嚥下関連筋支配神経の活動に対するイミダプリルの効果2019

    • Author(s)
      守谷崇, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 井上富雄
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Serotonin1B receptors are involved in presynaptic inhibition of proprioceptive afferent transmission to jaw-closing motoneurons2019

    • Author(s)
      Inoue T, Nagata A, Nakayama K, Dantsuji M, Nakamura S, Mochizuki A, Maki K
    • Organizer
      The 10th IBRO World Congress of Neuroscience
    • Related Report
      2019 Annual Research Report
  • [Presentation] Presynaptic Activation of 5-HT1B Receptors Inhibits Proprioceptive Sensory Inputs to Jaw-Closing Motoneurons2019

    • Author(s)
      Inoue T, Nagata A, Nakayama K, Dantsuji M, Nakamura S, Mochizuki A, Maki K.
    • Organizer
      FENS Regional Meeting 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Electrophysiological recordings of neurons derived from sleep bruxism patient-specific iPSCs2019

    • Author(s)
      Nakai K, Shiga T, Abe Y, Hoashi Y, Nakamura S, Yasuhara R, Matsumoto T, Avijite KS, Kotani K, Mishima K, Inoue T, Akamatsu W, Baba K
    • Organizer
      ISSCR Annual Meeting
    • Related Report
      2019 Annual Research Report
  • [Presentation] Patch-clamp recordings of neurons induced from sleep bruxism patient specific iPSCs2019

    • Author(s)
      Nakai K, Hoashi Y, Abe Y, Nakamura S, Siga T, Avijite KS, Yasuhara R, Matsumoto T, Kotani K, Inoue T, Mishima K, Akamatsu W, Baba K
    • Organizer
      97th general session & exhibition of the IADR
    • Related Report
      2019 Annual Research Report
  • [Presentation] 睡眠時ブラキシズム特異的iPS細胞由来GABA作動性神経細胞の電気生理学的評価2019

    • Author(s)
      中井健人,小溪啓介,帆足有理恵,松本貴志,安部友佳,安原理佳,美島健二,中村史朗,井上富雄,志賀孝宏,赤松和士,馬場一美
    • Organizer
      日本補綴歯科学会128回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 嚥下関連筋支配神経への嚥下改善薬の効果2019

    • Author(s)
      守谷崇, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 代田達夫, 井上富雄
    • Organizer
      日本顎口腔機能学会 第62回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 転写因子Phox2bを発現する小細胞性網様体ニューロンの生理学的解析2019

    • Author(s)
      梶原里紗,中村史朗,中山希世美,望月文子,壇辻昌典,飯島毅彦,井上富雄
    • Organizer
      第13回三叉神経領域の感覚-運動統合機構研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus2019

    • Author(s)
      Nakamura S, Nagoya K, Ikeda K, Onimaru H, Kawakami K, Nakayama K, Mochizuki A, Dantsuji M, Inoue T. Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus
    • Organizer
      9th FAOPS congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウスの睡眠覚醒ステージにおける咬筋活動に対するSSRIの影響2018

    • Author(s)
      池田美菜子,望月文子,中村史朗,中山希世美,馬場一美,井上富雄
    • Organizer
      日本顎口腔機能学会第60回学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Imaging analysis of respiratory-related burst activity in the parafacial region of newborn rat2018

    • Author(s)
      Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T
    • Organizer
      11th FENS Forum of Neuroscience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 咬筋運動ニューロン樹状突起のグルタミン酸応答に対するセロトニンの効果2018

    • Author(s)
      壇辻昌典,中村史朗,望月文子,中山希世美,尾関雅彦,井上富雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] マウスの睡眠覚醒ステージにおける咬筋活動に対するSSRIの影響2018

    • Author(s)
      池田美菜子,望月文子,中村史朗,中山希世美,馬場一美,井上富雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] マウスの脂質代謝におけるオレキシンの影響2018

    • Author(s)
      望月文子,中山希世美,中村史朗,壇辻昌典,井上富雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 発達期における閉口筋および開口筋運動ニューロンのグルタミン酸入力比較2018

    • Author(s)
      中村史朗,中山希世美,望月文子,壇辻昌典,井上富雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 閉口筋および開口筋運動ニューロンへの興奮性シナプス伝達の生後発達様式の比較2018

    • Author(s)
      中村史朗,中山希世美,望月文子,壇辻昌典,井上富雄
    • Organizer
      日本顎口腔機能学会第61回学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effects of pharmacological agents administered for swallowing disorders on swallowing motor activity in nerves innervating infrahyoid and laryngeal muscles2018

    • Author(s)
      Moriya T, Nakayama K, Nakamura S, Mochizuki A, Shirota T, Inoue T
    • Organizer
      Society for Neuroscience 48th annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Activation of 5-HT2A receptor enhances function of GluN2A-containing NMDA receptor via Src kinase in dendrites of rat jaw-closing motoneurons2018

    • Author(s)
      Dantsuji M, Nakamura S, Nakayama K, Mochizuki A, Park S, Bae Y, Ozeki M, Inoue T
    • Organizer
      Society for Neuroscience 48th annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 嚥下改善薬の使用による嚥下の影響2018

    • Author(s)
      守谷崇,中山希世美,望月文子,中村史朗,代田達夫,井上富雄
    • Organizer
      第65回昭和大学学士会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高分子Aβオリゴマーは細胞膜を破綻し神経細胞毒性を誘導する2018

    • Author(s)
      安本太郎,辻まゆみ,中村史朗,小野賢二郎,井上富雄,木内祐二
    • Organizer
      第65回昭和大学学士会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] マウスES細胞を用いた3次元唾液腺組織の分化誘導2018

    • Author(s)
      田中準一,小川美帆,北條宏徳,中村史朗,波多賢二,馬渕洋,安原理佳,西村理行,井上富雄,大庭伸介,斎藤一郎,辻 孝,美島健二
    • Organizer
      第17回再生医療学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Postnatal change of glutamatergic synaptic transmission in the jaw-closing and jaw-opening motoneurons2018

    • Author(s)
      Shimono S, Teshima R, Nakamura S, Nakayama K, Mochizuki A, Ikeda M, Inoue T
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Effects of imidapril on swallowing activity in in situ rat preparations2018

    • Author(s)
      Moriya T, Nakayama K, Nakamura S, Mochizuki A, Shirota T, Inoue T
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Activation of serotonin 2A receptor modulates NMDA receptor-mediated glutamate responses via Src in dendrites of rat jaw-closing motoneurons2017

    • Author(s)
      Dantsuji M, Nakamura S, Mochizuki A, Nakayama K, Kiyomoto M, Ozeki Masahiko, Inoue T
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 転写因子Phox2bを発現する三叉神経運動核背側網様体ニューロンの生理学的および形態学的解析2017

    • Author(s)
      那小屋公太,中村史朗,中山希世美,望月文子,吉田 篤,井上 誠,井上富雄
    • Organizer
      日本顎口腔機能学会第58回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラット三叉神経運動核の背側網様体に存在するPhox2b陽性ニューロンの電気生理学的および形態学的特性はPhox2b陰性ニューロンと異なる2017

    • Author(s)
      那小屋公太,中村史朗,中山希世美,望月文子,佐藤文彦,吉田 篤,井上 誠,井上富雄
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] ラット三叉神経運動核背側網様体に存在するPhox2b陽性ニューロンの生理学的・形態学的性質2017

    • Author(s)
      那小屋公太,中村史朗,中山希世美,望月文子,佐藤文彦,吉田 篤,井上 誠,井上富雄
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Glutamatergic synaptic currents of rat jaw-closing motoneurons during transition period from sucking to chewing2017

    • Author(s)
      Nakamura S, Nakayama K, Mochizuki A, Inoue T
    • Organizer
      Society for Neuroscience 47th annual meeting
    • Related Report
      2017 Research-status Report
  • [Presentation] Distinctive properties of Phox2b neurons located in the rat reticular formation dorsal to the trigeminal motor nucleus2017

    • Author(s)
      Nagoya K, Nakamura S, Ikeda K, Onimaru H, Nakayama K, Mochizuki A, Sato F, Yoshida A, Kawakami K, Inoue M, Inoue T
    • Organizer
      Society for Neuroscience 47th annual meeting
    • Related Report
      2017 Research-status Report
  • [Presentation] Postnatal changes of glutamatergic inputs to rat jaw-closing and jaw-opening motoneurons2017

    • Author(s)
      Teshima R, Shimono S, Nakamura S, Nakayama K, Mochizuki A, Ikeda M, Inoue T
    • Organizer
      第65回国際歯科研究学会日本部会総会・学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] The effect of citalopram administration on the occurrence of vigilance states in the mouse model of depression2017

    • Author(s)
      Mochizuki A, Ikeda M, Nakamura S, Nakayama K, Inoue T
    • Organizer
      第65回国際歯科研究学会日本部会総会・学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 咬筋運動ニューロン樹状突起における興奮性シナプス入力のセロトニンによる増幅機構2017

    • Author(s)
      壇辻昌典,中村史朗,望月文子,中山希世美,尾関雅彦,井上富雄
    • Organizer
      日本顎口腔機能学会第59回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 咬筋運動ニューロンへのシナプス入力に対するセロトニンの影響2017

    • Author(s)
      永田愛,中山希世美,中村史朗,望月文子,槇宏太郎,井上富雄
    • Organizer
      第64回昭和大学学士会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 自己組織化技術を用いたマウスES細胞由来3次元唾液腺組織の誘導2017

    • Author(s)
      田中準一,中村史朗,安原理佳,井上富雄,美島健二
    • Organizer
      第62回日本唾液腺学会総会・学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] The effects of Citalopram on the masseter muscle activity during non-REM sleep in mice2017

    • Author(s)
      Mochizuki A, Ikawa Y, Kato T, Ikeda M, Nakamura S, Nakayama K, Baba K, Inoue T
    • Organizer
      The 6th Annual International Institute for Integrative Sleep Medicine (IIIS) Symposium
    • Related Report
      2017 Research-status Report
  • [Presentation] Serotonergic modulation of glutamate-evoked responses through 5-HT2A receptors in the dendrites of rat jaw-closing motoneurons2016

    • Author(s)
      Dantsuji M, Nakamura S, Nakayama K, Mochizuki A, Kiyomoto M, Park SK, Bae C, Ozeki M, Inoue T
    • Organizer
      Society for Neuroscience 46th annual meeting
    • Place of Presentation
      San Diego, United States
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 三叉神経運動ニューロンへのグルタミン酸性シナプス伝達機構の生後変化2016

    • Author(s)
      中村史朗,望月文子,中山希世美,井上富雄
    • Organizer
      日本顎口腔機能学会第57回学術大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-10-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 覚醒制御に関わる脳内生理活性物質の三叉神経中脳路核ニューロンおよび閉口筋運動ニューロンに対する影響2016

    • Author(s)
      井上富雄,中村史朗,中山希世美,望月文子,清本聖文
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 発達期ラット三叉神経運動ニューロンへのグルタミン酸性シナプス入力2016

    • Author(s)
      中村史朗,中山希世美,望月文子,清本聖文,井上富雄
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ノンレム睡眠時の咬筋活動に対するシタロプラムの作用2016

    • Author(s)
      野川泰葉,望月文子,加藤隆史,片山慶祐,安部友佳,中村史朗,中山希世美,馬場一美,若林則幸,井上富雄
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] セロトニンは5-HT2A受容体を介してNMDA受容体機能を調節し咬筋運動ニューロンのグルタミン酸応答を増大する2016

    • Author(s)
      壇辻昌典,中村史朗,中山希世美,望月文子,清本聖文,尾関雅彦,井上富雄
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット三叉神経運動核背側領域に存在するPhox2b陽性ニューロンの電気生理学的特性2016

    • Author(s)
      那小屋公太,中村史朗,中山希世美,望月文子,清本聖文,井上富雄
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Serotonergic modulation of NMDA receptor-mediated glutamate responses in the dendrites of rat jaw-closing motoneurons2016

    • Author(s)
      Dantsuji M, Nakamura S, Nakayama K, Mochizuki A, Kiyomoto M, Ozeki M, Inoue T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Serotonin modulates NMDA receptor-mediated glutamate responses through 5-HT2A receptors in the dendrites of rat jaw-closing motoneurons2016

    • Author(s)
      Inoue T, Dantsuji M, Nakamura S, Nakayama K, Mochizuki A, Kiyomoto M, Ozeki M
    • Organizer
      10th FENS Forum of Neuroscience
    • Place of Presentation
      Copenhagen, Danmark
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 顎運動制御に関与する中枢神経機構の解明2016

    • Author(s)
      中村史朗
    • Organizer
      第330回昭和学士会例会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 新 よくわかる顎口腔機能2017

    • Author(s)
      井上富雄,中村史朗(分担執筆)
    • Total Pages
      304
    • Publisher
      医歯薬出版
    • ISBN
      9784263444894
    • Related Report
      2017 Research-status Report
  • [Book] 新 よくわかる顎口腔機能2017

    • Author(s)
      井上富雄,中村史朗(分担執筆)
    • Total Pages
      287
    • Publisher
      医歯薬出版
    • Related Report
      2016 Research-status Report
  • [Remarks] 昭和大学歯学部口腔生理学講座

    • URL

      http://www10.showa-u.ac.jp/~oralphys/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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