Research in the excitatory synaptic transmission during critical period of feeding
| Project/Area Number |
16K11488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 富雄 昭和大学, 歯学部, 教授 (70184760)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 生後発達 / 摂食行動 / 閉口筋運動ニューロン / シナプス伝達 / グルタミン酸性受容体 / 開口筋運動ニューロン / 顎運動 / 咀嚼筋支配運動ニューロン / グルタミン酸受容体 / 臨界期 / 咀嚼 / 吸啜 / 三叉神経運動ニューロン / 神経科学 / 生理学 / 興奮性シナプス伝達 |
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| Outline of Final Research Achievements |
We electrophysiologically investigated the developmental nature of glutamatergic synaptic transmission to the jaw-closing and jaw-opening motoneurons to elucidate the role of glutamatergic receptor functions in the regulation of feeding. The synaptic inputs mediated by NMDA receptors containing NR2A and NR2B subunits to the jaw-closing motoneurons decreased with postnatal age. In contrast, there were no differences of NMDA receptor-mediated synaptic inputs to the jaw-opening motoneurons throughout the postnatal period. These results suggest that the NMDA receptor-mediated synaptic inputs alter during postnatal period, which may contribute to the developmental transition of feeding behavior from suckling to mastication.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で明らかとなった、顎筋運動ニューロンにおけるグルタミン酸性シナプス伝達の生後発育変化は、吸啜から咀嚼への転換に重要な役割を果たしている可能性が考えられる。今回の基礎データは、摂食行動の臨界期制御機構の一端が明らかになっただけでなく、自閉症等の発達障害児で問題となる摂食障害の発症機序の解明にもつながり、歯科医学の分野だけでなく小児医学・生涯発達学などの多くの分野に貢献することができる。さらにNMDA受容体サブユニットをターゲットとした摂食障害の治療法開発につながるという波及効果も期待できる。
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Report
(5 results)
Research Products
(69 results)
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[Journal Article] Generation of orthotopically functional salivary gland from embryonic stem cells2018
Author(s)
Tanaka Junichi、Ogawa Miho、Hojo Hironori、Kawashima Yusuke、Mabuchi Yo、Hata Kenji、Nakamura Shiro、Yasuhara Rika、Takamatsu Koki、Irie Tarou、Fukada Toshiyuki、Sakai Takayoshi、Inoue Tomio、Nishimura Riko、Ohara Osamu、Saito Ichiro、Ohba Shinsuke、Tsuji Takashi、Mishima Kenji
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Journal Title
Nature Communications
Volume: 9
Issue: 1
Pages: 4216-4216
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus2017
Author(s)
Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Satoh F, Kawakami H, Takahashi K, Inoue T.
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Journal Title
Neuroscience
Volume: 358
Pages: 211-226
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice2016
Author(s)
Ikawa Y, Mochizuki A, Katayama K, Kato T, Ikeda M, Abe Y, Nakamura S, Nakayama K, Wakabayashi N, Baba K, Inoue T
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Journal Title
Neurosci Res
Volume: 113
Pages: 48-55
DOI
Related Report
Peer Reviewed
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[Presentation] Electrophysiological recordings of neurons derived from sleep bruxism patient-specific iPSCs2019
Author(s)
Nakai K, Shiga T, Abe Y, Hoashi Y, Nakamura S, Yasuhara R, Matsumoto T, Avijite KS, Kotani K, Mishima K, Inoue T, Akamatsu W, Baba K
Organizer
ISSCR Annual Meeting
Related Report
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[Presentation] Patch-clamp recordings of neurons induced from sleep bruxism patient specific iPSCs2019
Author(s)
Nakai K, Hoashi Y, Abe Y, Nakamura S, Siga T, Avijite KS, Yasuhara R, Matsumoto T, Kotani K, Inoue T, Mishima K, Akamatsu W, Baba K
Organizer
97th general session & exhibition of the IADR
Related Report
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[Presentation] Distinctive properties of Phox2b neurons located in the rat reticular formation dorsal to the trigeminal motor nucleus2017
Author(s)
Nagoya K, Nakamura S, Ikeda K, Onimaru H, Nakayama K, Mochizuki A, Sato F, Yoshida A, Kawakami K, Inoue M, Inoue T
Organizer
Society for Neuroscience 47th annual meeting
Related Report
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