Establishment of swallowing function evaluation method by Cine MRI

• Project/Area Number: 16K11514
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu Dental College
• Principal Investigator: Tanaka Tatsurou 九州歯科大学, 歯学部, 准教授 (50326469)
• Project Period (FY): 2016-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 摂食・嚥下機能評価 / Cine MRI / 摂食・嚥下機能障害 / 嚥下機能障害 / 診断 / 歯科放射線学 / 摂食・嚥下

Outline of Final Research Achievements

In this study, we attempted to evaluate swallowing function by Cine MRI using T2WI in patients with malignant tumors in the oral region. As a result, we were able to confirmed the flow of saline into the esophagus by Cine MRI of all patients. Various parameters of Cine MRI showed a significant correlation with the score of dysphagia by interviewing patients. We also showed that the mobility of the patient's soft tissues significantly deteriorated after surgery. In particular, it was confirmed that this tendency is remarkable in postoperative patients with a large degree of surgical invasiveness.

Academic Significance and Societal Importance of the Research Achievements

本研究ではT2強調像をベースにしたCine MRIにより、口腔癌患者の嚥下機能を評価することが可能であることを明らかにした。実際に全ての患者において誤嚥の有無を評価することが可能であった。更に、MR像であるため嚥下に関連する軟組織の可動性についても、個別に評価ができることも明らかにした。

Research Products

• [Journal Article] Real time-evaluation of swallowing in patients with oral cancers using cine-magnetic resonance imaging based on T2-weighted sequences. (2020)
  • Author(s): Tanaka T, Tanaka R, Yeung AWK, Bornstein MM, Nishimura S, Oda M, Habu M, Takahashi O, Yoshiga D, Sago T, Miyamoto I, Kodama M, Wakasugi-Sato N, Matsumoto-Takeda S, Joujima T, Miyamura Y, Morimoto Y
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 130 Issue: 5 Pages: 583-592
  • DOI: 10.1016/j.oooo.2020.05.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Predicting the therapeutic effect of carbamazepine in trigeminal neuralgia by analysis of neurovascular compression utilizing magnetic resonance cisternography (2019)
  • Author(s): Tanaka T.、Shiiba S.、Yoshino N.、Harano N.、Sago T.、Kito S.、Matsumoto-Takeda S.、Wakasugi-Sato N.、Oda M.、Joujima T.、Miyamura Y.、Imamura Y.、Morimoto Y.
  • Journal Title: International Journal of Oral and Maxillofacial Surgery Volume: 48 Issue: 4 Pages: 480-487
  • DOI: 10.1016/j.ijom.2018.09.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Advocacy of diagnostic criteria for maxillary incisive canal cysts based on alteration of normal maxillary incisive canals according to aging in Japanese populations (2019)
  • Author(s): Ueda N, Tanaka T, Oda M, Wakasugi-Sato N, Matsumoto-Takeda S, Miyamura Y, Jyoujima T, Kiyota K, Tsutsumi K, Morimoto Y
  • Journal Title: Head Face Med Volume: 15 Issue: 1 Pages: 25-25
  • DOI: 10.1186/s13005-019-0209-5
  • Peer Reviewed / Open Access
• [Journal Article] Significance and usefulness of imaging characteristics of gubernaculum tracts for the diagnosis of odontogenic tumors or cysts (2018)
  • Author(s): Oda M、Nishida I、Miyamoto I、Saeki K、Tanaka T、Kito S、Yamamoto N、Yada N、Yoshiga D、Matsumoto-Takeda S、Wakasugi-Sato N、Habu M、Kodama M、Kokuryo S、Osawa K、Nishimura S、Joujima T、Miyamura Y、Matsuo K、Tominaga K、Yoshioka I、Maki Ki、Morimoto Y
  • Journal Title: PLOS ONE Volume: 13 Issue: 7 Pages: e0199285-e0199285
  • DOI: 10.1371/journal.pone.0199285
  • Peer Reviewed / Open Access
• [Journal Article] Functional evaluation of swallowing in patients with tongue cancer before and after surgery using high-speed continuous magnetic resonance imaging based on T2-weighted sequences. (2017)
  • Author(s): Nishimura S, Tanaka T, Oda M, Habu M, Kodama M, Yoshiga D, Osawa K, Kokuryo S, Miyamoto I, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Joujima T, Miyamura Y, Hitomi S, Yamamoto N, Uehara M, Sasaguri M, Ono K, Yoshioka I, Tominaga K, Morimoto Y.
  • Journal Title: Oral surgery, oral medicine, oral pathology and oral radiology. Volume: 125 Issue: 1 Pages: 88-98
  • DOI: 10.1016/j.oooo.2017.09.012
  • Peer Reviewed
• [Journal Article] Basic and important points regarding the diagnosis of oral cancers using fluorine-18-labeled fluoro-2-deoxy-d-glucose positron emission tomography?computed tomography: a review (2017)
  • Author(s): Kito Shinji, Koga Hirofumi, Oda Masafumi, Tanaka Tatsurou, et al
  • Journal Title: Oral radiol Volume: 33 Issue: 3 Pages: 170-177
  • DOI: 10.1007/s11282-017-0273-0
  • Peer Reviewed
• [Journal Article] Alterations in 18F-FDG accumulation into neck-related muscles after neck dissection for patients with oral cancers (2016)
  • Author(s): Kito S, Koga H, Kodama M, Habu M, Kokuryo S, Oda M, Matsuo K, Nishino T, Matsumoto-Takeda S, Uehara M, Yoshiga D, Tanaka T, Nishimura S, Miyamoto I, Sasaguri M, Tominaga K, Yoshioka I, Morimoto Y
  • Journal Title: Med Oral Patol Oral Cir Bucal Volume: 21
  • Peer Reviewed
• [Journal Article] 口腔、顎、顔面領域の疾患に対する初学者のための画像検査の進め方 (2016)
  • Author(s): 森本泰宏，西村 瞬，田中達朗，小田昌史，鬼頭慎司，松本（武田）忍，若杉（佐藤）奈緒，武藤隆史
  • Journal Title: 歯放 Volume: 56 Pages: 8-16
  • NAID: 130005249484
  • Peer Reviewed
• [Presentation] 三叉神経痛 の治療効果予測におけるMR cisternographyを用いた新たなアプローチ法 (2019)
  • Author(s): 田中達朗, 小田昌史, 若杉奈緒, 松本忍, 城嶋孝章, 宮村侑一, 森本泰宏
  • Organizer: 第60回 日本歯科放射線学会学術大会
• [Presentation] T2強調像を応用した超高速MRIによる舌癌患者の手術前後における嚥下機能評価の有効性 (2018)
  • Author(s): 西村 瞬, 田中達朗, 小田昌史, 今村義治, 城嶋孝章, 宮村侑一, 若杉（佐藤）奈緒, 松本（武田）忍, 鬼頭慎司, 森本泰宏
  • Organizer: 日本歯科放射線学会総会・学術大会
• [Presentation] Cine MRIによる摂食嚥下機能の評価 (2017)
  • Author(s): 4.田中達朗，西村 瞬，小田昌史，若杉奈緒，松本 忍，鬼頭慎司，森本泰宏
  • Organizer: 第17回日本外傷歯歯学会総会・学術大会
• [Presentation] 高速撮像MRIを利用した嚥下機能評価法の臨床応用 (2017)
  • Author(s): 6.西村 瞬，田中達朗，小田昌史，鬼頭慎司，若杉（佐藤）奈緒，松本（武田）忍，宮村侑一，城嶋孝章，今村義治，森本泰宏
  • Organizer: 第27回日本口腔内科学会・第30回日本口腔診断学会学術大会
• [Presentation] Cine MRIによる嚥下機能評価の試み (2016)
  • Author(s): 田中達朗, 西村 瞬, 小田昌史, 鬼頭慎司, 松本（武田）忍, 森本泰宏
  • Organizer: 第23回日本歯科医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2016-10-21
• [Presentation] 『ここまでわかる画像診断』-超高速撮像 MRI を利用した嚥下機能評価法の開発 (2016)
  • Author(s): 西村 瞬, 田中達朗 , 小田昌史, 鬼頭慎司, 松本（武田）忍, 森本泰宏
  • Organizer: 第26回日本口腔内科学会・第29回日本口腔診断学会合同学術大会
  • Place of Presentation: 岡山
  • Invited