| Project/Area Number |
16K11521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Keio University |
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Principal Investigator |
Asoda Seiji 慶應義塾大学, 医学部(信濃町), 講師 (80296706)
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| Co-Investigator(Kenkyū-buntansha) |
森川 暁 慶應義塾大学, 医学部(信濃町), 講師 (00424169)
吉川 桃子 慶應義塾大学, 医学部(信濃町), 訪問研究員 (50570967)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | CD44v / 口腔扁平上皮癌 / SpCC / CD44 / EMT / CD326 / CD140a / 癌 / トランスレーショナルリサーチ / 口腔 |
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| Outline of Final Research Achievements |
Our group focused on cancer-associated mesenchymal / stromal cells of cetuximab-resistant oral squamous cell carcinoma. We aimed at personalized treatment by constructing expression profiles of CD44v and novel mesenchymal markers.Analysis of cetuximab-resistant undifferentiated oral squamous cell carcinoma using tissue sample revealed that tissue-derived cells expressed both epithelial marker, EpCAM and mesenchymal marker, PDGFRα.The cancer stem cell marker CD44v-positive cells were identified in both cell fractions.
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| Academic Significance and Societal Importance of the Research Achievements |
SpCCの検体を用いて間質特異的細胞表面マーカーやその細胞特性評価を行い、病理診断のみでは予測できない細胞の性質や機能を明らかにした。その上で、効果的薬剤が定まっていないSpCCに対するイマチニブによる新規治療の可能性を見出した。
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