| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Periodontal disease is a chronic inflammatory disease in which periodontopathic bacteria interact with host cells to destroy periodontal tissue.The host defenses have various immune responses as a protective response against bacteria.Recent studies have identified novel lymphocytes subsets named innate lymphoid cells (ILCs). ILCs are present in a wide variety of epithelial compartment and occupy an intermediate position between the innate and acquired immune system. ILCs play essential roles in protection against various invading microorganisms including multicellular parasites, and the maintenance of homeostasis and repair of epithelial layers. In this study, identifying and analyzing ILCs localized in the periodontal tissue can be expected to lead not only to the elucidation of preventive methods and treatment for periodontal diseases.
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