• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Developing the model using pH/calcium fluorescent imaging for prevention and treatment of dental caries

Research Project

Project/Area Number 16K11540
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionTohoku University

Principal Investigator

MAYANAGI Gen  東北大学, 歯学研究科, 助教 (10451600)

Co-Investigator(Kenkyū-buntansha) 鷲尾 純平  東北大学, 歯学研究科, 講師 (20400260)
高橋 信博  東北大学, 歯学研究科, 教授 (60183852)
佐藤 拓一  新潟大学, 医歯学系, 教授 (10303132)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細菌 / pH / カルシウム / エナメル質齲蝕 / 根面齲蝕 / フッ化物徐放性歯科材料 / インターフェイス / 蛍光イメージング / 脱灰 / pH / う蝕
Outline of Final Research Achievements

This study aimed to develop the methods to assess pH change at the interface between material or tooth and bacteria continuously under the same kind of conditions as an oral microenvironment in vitro. The fluoride releasing materials and the silver diamine fluoride coated tooth inhibited pH fall at the interface between material/tooth and bacteria. The degree of inhibition of pH fall seemed to correspond to the amounts of fluoride and silver detected, suggesting that the fluoride and silver released from these materials inhibited pH fall.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、歯面や歯根面の詳細な脱灰メカニズムの解明に寄与するものであり、齲蝕の予防・治療に効果のある歯科材料・食品・薬剤等の評価や開発に応用が可能なことに加えて、より精度の高い齲蝕の基礎研究・臨床研究への展開が期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (29 results)

All 2020 2019 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results)

  • [Journal Article] Electrochemical evaluation of the hydrogen peroxide- and fluoride-induced corrosive property and its recovery on the titanium surface2020

    • Author(s)
      Furiya-Sato S, Fukushima A, Mayanagi G, Sasaki K, Takahashi N
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 64 Issue: 3 Pages: 307-312

    • DOI

      10.1016/j.jpor.2019.09.002

    • NAID

      130007885745

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Profiling of microbiota in liquid baby formula consumed with an artificial nipple2019

    • Author(s)
      SANO Hiroto、WAKUI Anna、KAWACHI Miho、KATO Rito、MORIYAMA Sachie、NISHIKATA Mayumi、WASHIO Jumpei、ABIKO Yuki、MAYANAGI Gen、YAMAKI Keiko、SAKASHITA Reiko、TOMIDA Junko、KAWAMURA Yoshiaki、TANAKA Kaori、TAKAHASHI Nobuhiro、SATO Takuichi
    • Journal Title

      Biomedical Research

      Volume: 40 Issue: 4 Pages: 163-168

    • DOI

      10.2220/biomedres.40.163

    • NAID

      130007689885

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sodium fluoride and silver diamine fluoride-coated tooth surfaces inhibit bacterial acid production at the bacteria/tooth interface.2019

    • Author(s)
      Ishiguro T, Mayanagi G, Azumi M, Otani H, Fukushima A, Sasaki K, Takahashi N
    • Journal Title

      J Dent.

      Volume: 印刷中 Pages: 30006-5

    • DOI

      10.1016/j.jdent.2018.12.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corrosive effects of fluoride on titanium under artificial biofilm2018

    • Author(s)
      Fukushima Azusa、Mayanagi Gen、Sasaki Keiichi、Takahashi Nobuhiro
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 62 Issue: 1 Pages: 104-109

    • DOI

      10.1016/j.jpor.2017.08.004

    • NAID

      130006619327

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory effect of resin composite containing S-PRG filler on Streptococcus mutans glucose metabolism2018

    • Author(s)
      Kitagawa Haruaki、Miki-Oka Saeki、Mayanagi Gen、Abiko Yuki、Takahashi Nobuhiro、Imazato Satoshi
    • Journal Title

      J Dent.

      Volume: 70 Pages: 92-96

    • DOI

      10.1016/j.jdent.2017.12.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] pH Response and Tooth Surface Solubility at the Tooth/Bacteria Interface2017

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Takahashi N
    • Journal Title

      Caries Res

      Volume: 51 Issue: 2 Pages: 160-166

    • DOI

      10.1159/000454781

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 母乳および新生児の口腔内の細菌叢解析:保管による影響について2020

    • Author(s)
      佐野拓人、涌井杏奈、河内美帆、森山幸枝、西方真弓、鷲尾純平、安彦友希、真柳 弦、高橋信博、佐藤拓一
    • Organizer
      第9回口腔保健用機能性食品研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ニプル(哺乳瓶用乳首)を通した、口腔から液体ミルク内への流入2020

    • Author(s)
      涌井杏奈、佐野拓人、河内美帆、鷲尾純平、安彦友希、真柳 弦、高橋信博、佐藤拓一
    • Organizer
      第9回口腔保健用機能性食品研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 口腔内マルチイオン測定マイクロデバイスのためのカルシウムイオン選択電極の作製2020

    • Author(s)
      真柳弦,髙橋信博,齊藤滉佑,石原昇,栁田保子
    • Organizer
      令和元年度生体医歯工学研究拠点成果報告会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Diamond-like carbon膜コーティング・チタンのバイオフィルム形成抑制効果の検討2019

    • Author(s)
      真柳 弦, 佐藤 秀明, 石幡 浩志, 吉川 亮太, 藤本 佑典, 山田 聡, 高橋 信博
    • Organizer
      第62回春季日本歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Profiling of microbiota in baby-drinks and liquid baby formula consumed with an artificial nipple2019

    • Author(s)
      Wakui A, Sano H, Kawachi M, Kato R, Washio J, Abiko Y, Mayanagi G, Yamaki K, Takahashi N, Sato T
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Involvementt of oral bacteria -Importance of analyzing bacterial metabolic activity-2019

    • Author(s)
      Washio J, Mayanagi G, Abiko Y, Yanagida Y, Takahashi N
    • Organizer
      第4回生体医歯工学共同研究拠点国際シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Electrochemical evaluation of the hydrogen peroxide-and fluoride-induced corrosive property and its recovery on the titanium surface.2019

    • Author(s)
      Sato S, Fukushima A, Mayanagi G, Sasaki K, Takahashi N
    • Organizer
      International Symposium for Multimodal research and Education in IOHS-Liaison 2019.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 哺乳瓶用乳首(ニプル)を通して乳児用飲料を飲んだ際の,口腔からの逆流について2019

    • Author(s)
      涌井杏奈,佐野拓人,河内美帆,高橋彩朱伽,加藤理都,鷲尾純平,安彦友希,石黒和子,真柳 弦,高橋信博,佐藤拓一
    • Organizer
      第8回口腔保健用機能性食品研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 口腔内微小環境マルチイオン測定マイクロデバイスのためのイオン選択膜の作成2019

    • Author(s)
      真柳 弦、髙橋信博、齋藤滉佑、石原昇、柳田保子
    • Organizer
      平成30年度 生体医歯工学研究拠点成果報告会
    • Related Report
      2018 Research-status Report
  • [Presentation] ニプルを通して飲んだ際の、ベビー飲料内への口腔細菌の流入2018

    • Author(s)
      相原 瞳、涌井杏奈、佐野拓人、河内美帆、鷲尾純平、安彦友希、真柳 弦、 八巻恵子、高橋信博、佐藤拓一
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Profiling of Microbiota of Baby-Drinks after Drinking with Artificial Nipples.2018

    • Author(s)
      Wakui A, Sano H, Aihara H, Kawachi M, Takahashi A, Washio J, Abiko Y, Mayanagi G, Ishiguro K, Yamaki K, Takahashi N, Sato T
    • Organizer
      JADR2018/ 66th Japanese Division Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 非破壊的超高感度細胞内ATP及びNADH計測マイクロデバイスの開発2018

    • Author(s)
      鷲尾純平、真柳弦、髙橋信博、柳田保子
    • Organizer
      東京工業大学 科学技術創成研究院 未来産業技術研究所-東北大学大学院歯学研究科 包括的研究協力協定にかかる連携シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] Microbiota Profiling at the Mouth of Plastic Bottles after Drinking Straight from Bottles2018

    • Author(s)
      Sano H, Aida A, Vidanapathirana GU, Wakui A, Hirabuki Y, Takenaka Y, Kawachi M, Aihara H, Washio J, Abiko Y, Mayanagi G, Ishiguro K, Yamaki K, Takahashi N, Sato T
    • Organizer
      International Symposium for Multimodal Research and Education in IOHS-Liaison 2018 -International Symposium for Interface Oral Health Science 2018-
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ペットボトルの口の部分に付着する細菌および飲料物中の細菌の量および構成の解析(第2報)2018

    • Author(s)
      河内美帆、佐野拓人、涌井杏奈、平吹有香、曾田彩花、竹中佑太、米田茜音、中畑那奈、相原瞳、Vidanapathirana GU、佐藤拓一、鷲尾純平、安彦友希、石黒和子、真柳弦、高橋信博
    • Organizer
      第7回口腔保健用機能性食品研究会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 細菌-材料インターフェイスにおけるフッ素徐放性材料のpH低下抑制効果の評価および将来への展望2018

    • Author(s)
      真柳弦、鷲尾純平、高橋信博、柳田保子、伊藤浩之、石原昇、益一哉
    • Organizer
      平成29年度生体医歯工学共同研究拠点成果報告会
    • Related Report
      2017 Research-status Report
  • [Presentation] スマートデバイスを用いた口腔微小環境マルチイオン測定2017

    • Author(s)
      真柳弦、五十嵐公英、鷲尾純平、土門ひと美、高橋信博、柳田保子、伊藤浩之、石原昇、益一哉
    • Organizer
      東工大未来研-東北大歯学研究科 包括的研究協力協定 第5回研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] pH response and tooth surface solubility at the tooth/bacteria interface2017

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Takahashi N
    • Organizer
      The 2nd International Symposium on Biomedical Engineering
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ペットボトルの口の部分に付着する細菌の量および構成(A pilot study)2017

    • Author(s)
      曾田彩花、佐藤拓一、石黒和子、安彦友希、真柳 弦、鷲尾純平、高橋信博
    • Organizer
      第6回口腔保健用機能性食品研究会・総会
    • Place of Presentation
      鶴見大学会館(神奈川県)
    • Related Report
      2016 Research-status Report
  • [Presentation] スマートISFETを用いた口腔微小環境マルチイオン測定2017

    • Author(s)
      真柳弦、五十嵐公英、鷲尾純平、中條和子、土門ひと美、高橋信博
    • Organizer
      東北大歯学研究科-東工大未来研学術連携シンポジウム
    • Place of Presentation
      東北大学大学院歯学研究科(宮城県)
    • Related Report
      2016 Research-status Report
  • [Presentation] 歯質-細菌インターフェイスにおける歯質脱灰の評価2017

    • Author(s)
      真柳弦、高橋信博、益一哉
    • Organizer
      平成28年度生体医歯工学共同研究拠点成果報告会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of pH using an ISFET at the bacteria/restorative materials interface2016

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon H, Takahashi N
    • Organizer
      International Symposium on Biomedical Engineering
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Corrosive effects of fluoride on titanium under artificial biofilm of Streptococcus mutans2016

    • Author(s)
      Fukushima A, Mayanagi G, Sasaki K, Takahashi N
    • Organizer
      The 11th International Workshop on Biomaterials in Interface Science Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2016
    • Place of Presentation
      東北大学大学院歯学研究科(宮城県)
    • Year and Date
      2016-08-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ISFETのう蝕研究への展開2016

    • Author(s)
      真柳弦、五十嵐公英、鷲尾純平、中條和子、土門ひと美、高橋信博
    • Organizer
      第5回生体医歯工学公開セミナー
    • Place of Presentation
      東京工業大学すずかけ台キャンパス(神奈川県)
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi