• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of alpha-SMA expressing cells in dental pulp wound healing and regeneration

Research Project

Project/Area Number 16K11546
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionNiigata University

Principal Investigator

Yoshiba Nagako  新潟大学, 医歯学総合病院, 講師 (10323974)

Co-Investigator(Kenkyū-buntansha) 大倉 直人  新潟大学, 医歯学総合病院, 助教 (00547573)
吉羽 邦彦  新潟大学, 医歯学系, 教授 (30220718)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords歯髄保存治療 / 創傷治癒 / α-SMA / fibrocyte / α-smooth muscle actin / dental pulp / wound healing / 歯髄組織 / myofibroblast / dental pulp tissue
Outline of Final Research Achievements

Dental pulp is a soft connective tissue encased in mineralized dentine. When dentine continuity is disrupted by caries or traumatic injury, the resident odontoblasts are also destroyed at that site. Pulp capping agents can help to cover the site through the production of a mineralized matrix through the activation of newly differentiated odontoblast-like cells, however, the exact mechanisms of the process have not been fully revealed. The present study has demonstrated that α-SMA expressing cells play a crucial role in the wound healing.

Academic Significance and Societal Importance of the Research Achievements

歯髄幹細胞の存在する場所の1つとして、pulp coreと呼ばれる歯髄組織の中心部にある太い血管があげられている。本研究において、このpulp coreに存在するある種のα-SMA陽性壁細胞が増殖し、創傷部位に移動し、修復象牙芽細胞に分化する可能性が示唆された。その際、骨髄由来のfibrocyteと称される細胞も歯髄組織に入り込み、治癒の促進をしていることも示唆された。これらのことは、歯髄組織が少しでも残っていれば、その組織を再生に導くことができる可能性を示唆するものであり、学術的、社会的意義は大きいと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Detection of bone marrow-derived fibrocytes in human dental pulp repair2018

    • Author(s)
      Yoshiba N, Edanami N, Tohma A, Takeuchi R, Ohkura N, Hosoya A, Noiri Y, Nakamura H, Yoshiba K.
    • Journal Title

      International Endodontic Journal

      Volume: 51 Issue: 11 Pages: 1187-1195

    • DOI

      10.1111/iej.12940

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of bone marrow-derived fibrocytes in human dental pulp repair2018

    • Author(s)
      Yoshiba N, Edanami N, TohmaA, Takeuchi R, Ohkura N, Hosoya A, Noiri Y, Nakamura H, Yoshiba K
    • Journal Title

      International Endodontic Journal

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of Dental Pulp Myofibroblasts in Rat Molars after Pulpotomy2017

    • Author(s)
      Edanami N, Yoshiba N, Ohkura N, Takeuchi R, Tohma A, Noiri Y, Yoshiba K
    • Journal Title

      Journal of Endodontics

      Volume: 43 Issue: 7 Pages: 1116-1121

    • DOI

      10.1016/j.joen.2017.02.018

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of Dental Pulp Myofibroblasts in Rat Molars after Pulpotomy2017

    • Author(s)
      N Edanami, N Yoshiba, N Ohkura, R Takeuchi, A Tohma, Y Noiri, K Yoshiba
    • Journal Title

      Journal of Endodontics

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Bone marrow-derived fibrocytes are involved in human dental pulp repair.2018

    • Author(s)
      Yoshiba N, Edanami N, Tohma A, Takeuchi R, Ohkura N, Oda Y, Hosoya A, Noiri Y, Nakamura H, Yoshiba K.
    • Organizer
      IADR General Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト歯髄組織創傷治癒過程における骨髄由来間葉系前駆細胞fibrocyteの動態検索2017

    • Author(s)
      吉羽永子, 大倉直人, 細矢明宏, 中村浩彰, 野杁由一郎, 吉羽邦彦
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラット臼歯断髄後におけるmyofibroblastの動態解析2017

    • Author(s)
      枝並直樹,吉羽永子,大倉直人,野杁由一郎,吉羽邦彦
    • Organizer
      第50回新潟歯学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 歯髄創傷治癒過程にけるマクロファージの集積とmyofibroblast様細胞の分化2017

    • Author(s)
      枝並直樹,吉羽邦彦, 吉羽永子,大倉直人,竹内涼介, 遠間愛子, 野杁由一郎
    • Organizer
      日本歯科保存学会 2017年度秋季学術大会(第147回)
    • Related Report
      2017 Research-status Report
  • [Presentation] Myofibroblasts in dental pulp healing after pulpotomy with mineral trioxide aggregate (MTA) in rat molars2016

    • Author(s)
      N Edanami, N Yoshiba, N Ohkura, R Takeuchi, A Tohma, K Yoshiba
    • Organizer
      IADR Pulp Biology and Regeneration Group Symposium
    • Place of Presentation
      名古屋コングレスセンター(愛知県名古屋市)
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fibrillin-1 microfibrils influence human dental pulp regeneration2016

    • Author(s)
      N Yoshiba, K Yoshiba, N Ohkura, N Edanami, R Takeuchi, A Tohma, Y Oda, A Hosoya, H Nakamura, T Okiji
    • Organizer
      IADR Pulp Biology and Regeneration Group Symposium
    • Place of Presentation
      名古屋コングレスセンター(愛知県名古屋市)
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi