Application of anti-inflammatory small molecule compound, terrein and its novel analogue, for the treatment of endodontic or periodontal diseases.
| Project/Area Number |
16K11549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中山 真彰 岡山大学, 医歯薬学総合研究科, 助教 (10579105)
高柴 正悟 岡山大学, 医歯薬学総合研究科, 教授 (50226768)
萬代 大樹 岡山大学, 自然科学研究科, 特任助教 (60534427)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | terrein / 歯周炎 / 根尖性歯周炎 / 歯周病 / 歯周・歯内疾患 / 低分子化合物 / 歯内疾患 / 歯周疾患 / 抗炎症 / 有機合成化学 |
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| Outline of Final Research Achievements |
In this study, we examined the possibility of the anti-inflammatory small molecule compound terrein as a therapeutic agent for inflammatory bone resorption diseases (especially endodontic or periodontal diseases). As a result of present study, (1) success of synthesized new terrein analogues, which have inhibitory effect of osteoclast differentiation, (2) one of the intracellular target molecules of terrain is JAK1, (3) intraperitoneal administration of terrein significantly inhibited alveolar bone resorption in the mouse ligature-induced periodontal disease model, and terrain suppressed the infiltration of inflammatory cells into the subepithelial region. The results suggest that terrein, a low molecular weight compound, may be applied as a treatment for endodontic or periodontal diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
近年，自身の歯が多数残る高齢者数は増加しており，8020運動達成者の割合が50%を超えたと報告されている。一方，歯が口腔内に残存することに伴い，う蝕や歯周病の発症リスクも上昇している。そのため，今後，口腔内に多量の感染・炎症巣を持つ高齢者の割合が増加することは，口腔感染に伴う全身疾患（誤嚥性肺炎等）の発症リスクを上昇させる，すなわち医療費の増加につながると考える。今回報告した低分子化合物terreinの口腔組織（炎症性細胞，上皮 骨組織等）に対する様々な薬理効果を応用することが出来れば，超高齢社会を意識した新たな口腔疾患治療（予防）薬として応用できると考える。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblasts2018
Author(s)
Satoshi Yamamoto, Kazuhiro Omori, Hiroki Mandai, Masaaki Nakayama, Saki Nakagawa, Hiroya Kobayashi, Tadashi Kunimine, Hiroshi Yoshimura, Kyosuke Sakaida, Hidefumi Sako, Soichiro Ibaragi, Tadashi Yamamoto, Hiroshi Maeda, Seiji Suga, and Shogo Takashiba
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Journal Title
Heliyon
Volume: 4
Issue: 11
Pages: e00979-e00979
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 真菌二次代謝産物terreinはマウス歯周病モデルにおける歯槽骨吸収を抑制する2019
Author(s)
佐光 秀文, 大森 一弘, 中川 沙紀, 坂井田 京佑, 山本 総司, 青柳 浩明, 小林 寛也, 大野 充昭, 平井 公人, 山城 圭介, 山本 直史, 高柴 正悟
Organizer
第39回日本歯科薬物療法学会総会・学術大会
Related Report
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[Presentation] Fungal metabolite, terrein, suppresses IL-6/sIL-6R-induced CSF1 secretion in gingival fibroblasts2017
Author(s)
S. Yamamoto, K Omori, A. Goto, H. Kobayashi, S. Nakagawa, A. Nakamura, D. Yamamoto, T. Yamamoto, S. Takashiba
Organizer
95th, International Association for Dental Research
Place of Presentation
San Francisco, CA, USA
Related Report
Int'l Joint Research
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