| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
A new product containing the peptide P11-4 was recently introduced to enhance remineralization and inhibit demineralization of the tooth substrate. Peptide P11-4 self-assembles into a three-dimensional (3D) scaffold on the surface of the tooth, where it promotes hydroxyapatite precipitation while inhibiting diffusive mineral loss. Therefore, due to its mineralization effect, this material is potentially useful not only for early carious lesions but also for enamel defects caused by erosion and tooth wear. Considering the potential of the self-assembly peptide P11-4 to enhance enamel remineralization, the purpose of this study was to use ultrasonic measurements to evaluate the preventive effects of peptide P11-4 on acidic erosion of enamel substrates.
Within the limitations of this in vitro study, application of the self-assembling peptide P11-4 may be able to prevent the progress of erosion from acid challenge and even to promote remineralization.
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