Basic study on efficacy of root canal irrigation using hard tissue decomposition abilit

• Project/Area Number: 16K11568
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: SUZUKI JIRO 神奈川歯科大学, 大学院歯学研究科, 講師 (00247313)
• Co-Investigator(Kenkyū-buntansha): 石井 信之 神奈川歯科大学, 大学院歯学研究科, 教授 (20163610) ; 浜田 信城 神奈川歯科大学, 大学院歯学研究科, 教授 (20247315) ; 佐藤 武則 神奈川歯科大学, 大学院歯学研究科, 助教 (40638904)
• Project Period (FY): 2016-10-21 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: EDTA / 根管洗浄 / 歯内療法 / 殺菌作用 / アルカリ性 / 根管洗浄剤 / 抗菌効果 / 脱灰 / 根管治療

Outline of Final Research Achievements

The purpose of this present study was to evaluate and analyze the new clear colored chemical cleaning agent (prototype 17% EDTA gel, PENTRON JAPAN), which has great visibility of the root canal foramen for the effectiveness of lubrication and removal of the smear layer created on the dentin surface of root canals.The results of prototype 17% EDTA gel showed the effectiveness of demineralization action and smear layer removal within the appropriate range at each measuring point on the dentin of the root canal. Moreover, the gel has excellent transparency so that it can reduce blocking the visual aspects of the operation, and safer root canal treatment can be made.

Academic Significance and Societal Importance of the Research Achievements

歯内療法における根管洗浄は，機械的に除去できない感染源を化学的に除去する重要な操作で，現在，有機質除去が可能な次亜塩素酸ナトリウム (NaClO) 溶液と無機質除去が可能なエチレンジアミン四酢酸 (EDTA) 溶液を用いた方法が推奨されている．しかしながら，複雑な根管系への応用性と優れた根管洗浄効果を併せ持つ洗浄液の開発が期待されている．また，EDTA製材は根管形成時における、ファイル操作時の補助材としても推奨されており，同材の潤滑効果が及ぼす影響についても検討を行ったところ，試作EDTA製材は，無機質および有機質に対する根管洗浄効果を有し，回転切削器具への潤滑効果を有することが確認された．

Research Products

• [Journal Article] A Questionnaire Survey for Rubber Dam Usage During Endodontic Procedure (2018)
  • Author(s): Jiro Suzuki，Ryuji fujimaki，Tani-Ishii Nobuyuki
  • Journal Title: The international Journal of Microdentistry Volume: 8 Pages: 42-48
  • NAID: 130008043639
  • Peer Reviewed
• [Journal Article] The Clinical evaluation of vertical root fracture after endodontic treatment with mineral trioxide aggregate (2018)
  • Author(s): Nobuyuki Tani-Ishii, Noriko Mutoh, Koichiro Muromachi and Jiro Suzuki
  • Journal Title: Integrative Molecular Medicine Volume: 4 Pages: 1-5
  • Peer Reviewed / Open Access
• [Presentation] Evaluation of root canal dentin adhesion after irrigation by Prototype Alkaline EDTA Solution (2018)
  • Author(s): Ryuji fujimaki，Jiro Suzuki，Tani-Ishii Nobuyuki
  • Organizer: American Association of Endodontists
  • Int'l Joint Research
• [Presentation] Evaluation of smear layer removal and lubrication effect by prototype EDTA gel conditioner (2018)
  • Author(s): Ryuji fujimaki，Jiro Suzuki，Tani-Ishii Nobuyuki
  • Organizer: IFEA，Seoul, Korean
  • Int'l Joint Research
• [Presentation] Evaluation of reducing torsional stress by prototype EDTA : An In Vitro measurement (2018)
  • Author(s): Jiro Suzuki，Ryuji fujimaki，Tani-Ishii Nobuyuki
  • Organizer: IFEA，Seoul, Korean
  • Int'l Joint Research
• [Presentation] Advantageous Effect of Stress Reduction by EDTA Lubricant for Root Canals Preparation (2018)
  • Author(s): Jiro Suzuki，Ryuji fujimaki，Tani-Ishii Nobuyuki
  • Organizer: American Association of Endodontists
  • Int'l Joint Research
• [Presentation] Optimum Concentration of EDTA Solution for Cleaning Root Canals (2017)
  • Author(s): Ryuji Fujimaki, Jiro Suzuki Nobuyuki Tani-Ishii
  • Organizer: American Association of Endodontists
  • Int'l Joint Research
• [Presentation] 試作アルカリ性EDTA溶液を用いた根管洗浄効果に関する研究 ―象牙質脱灰作用と抗菌効果― (2017)
  • Author(s): 藤巻龍治, 鈴木二郎, 佐藤武則, 大橋 桂 ,浜田信城, 石井信之
  • Organizer: 日本歯科保存学会
• [Presentation] 試作EDTA根管洗浄液による象牙質脱灰作用と抗菌効果 (2017)
  • Author(s): 藤巻龍治, 鈴木二郎, 佐藤武則 , 石井信之
  • Organizer: 日本歯内療法学会
• [Presentation] Applicability of Root Canal Irrigation with Prototype EDTA Solution－Evaluation of Mineralization Effect on Root Canal Dentin－ (2016)
  • Author(s): Ryuji fujimaki，Jiro Suzuki， Tani-Ishii Nobuyuki
  • Organizer: Korean Academy of Endodontics
  • Place of Presentation: Seoul, Korean
  • Year and Date: 2016-11-19
  • Int'l Joint Research
• [Presentation] EDTA溶液の根管洗浄効果における最適濃度の検討 (2016)
  • Author(s): 藤巻龍治，鈴木二郎，大橋桂，石井信之
  • Organizer: 日本歯科保存学会2016 秋季学術大会
  • Place of Presentation: キッセイ文化ホール（長野県）
  • Year and Date: 2016-10-27