Chronic muscle pain due to the impairment of myoblast fusion

• Project/Area Number: 16K11580
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tohoku Fukushi University
• Principal Investigator: Masahiro Tsuchiya 東北福祉大学, 健康科学部, 教授 (60372322)
• Co-Investigator(Kenkyū-buntansha): 神崎 展 東北大学, 医工学研究科, 准教授 (10272262) ; 渡邉 誠 東北福祉大学, その他, 教授 (80091768) ; 萩原 嘉廣 東北大学, 医学系研究科, 准教授 (90436139)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 顎関節症 / 好中球 / IL1 / 糖代謝 / 筋衛星細胞 / IL-1 / 慢性筋痛 / 筋細胞融合 / 筋痛

Outline of Final Research Achievements

Skeletal muscle regeneration after injury is a complex process involving inflammatory microenvironments. Interleukin (IL)-1 is a key mediator of inflammatory responses and exerts pleiotropic impacts on various cell types. Thus, we aimed to investigate the role of IL-1 during skeletal muscle regeneration. We herein show that IL-1KO mice exhibit delayed muscle regeneration characterized by delayed infiltrations of immune cells accompanied by suppressed local production of proinflammatory factors including IL-6 and delayed increase of satellite cells postinjury. Meanwhile, IL-1β secretion and NLRP3 inflammasome activation in macrophages produced mechanical hyperalgesia on over-exercised muscle pain. Taken together, we conclude that IL-1 plays a positive role in muscle regeneration, but also reduces over-exercised muscle pain.

Academic Significance and Societal Importance of the Research Achievements

顎関節症に伴う慢性筋痛の多くは筋・筋膜性疼痛疾患(MPS)と同様の症状を含み，異常な線維性構造（索状硬結）の存在と遷延化した炎症性サイトカイン産生を特徴とする．しかしながら，その発症メカニズムは不明であり，治療法も確立されていない．
運動後の筋組織ではIL1βの発現上昇と細胞融合の活性化が報告されている．本研究ではその現象に着目し，運動後に浸潤する炎症性細胞がIL-1βを介して筋痛を誘導することを明らかとした．IL-1は主要な炎症性サイトカインとしての働きが知られる一方で、そのメカニズムについては不明な点が多いが、我々の結果はIL-1の新規性のある働きを示すものである．

Research Products

• [Journal Article] Association between lower back pain and lower extremity pain among young volleyball players: A cross-sectional study (2020)
  • Author(s): Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Itoi Eiji、Nagatomi Ryoichi
  • Journal Title: Physical Therapy in Sport Volume: 43 Pages: 65-69
  • DOI: 10.1016/j.ptsp.2020.02.005
  • Peer Reviewed / Open Access
• [Journal Article] Upper Extremity Pain Is Associated with Lower Back Pain among Young Basketball Players: A Cross-Sectional Study (2020)
  • Author(s): Hagiwara Yoshihiro、Yabe Yutaka、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Itoi Eiji、Nagatomi Ryoichi
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 250 Issue: 2 Pages: 79-85
  • DOI: 10.1620/tjem.250.79
  • NAID: 130007798065
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Restriction in the hip internal rotation of the stride leg is associated with elbow and shoulder pain in elite young baseball players (2020)
  • Author(s): Sekiguchi Takuya、Hagiwara Yoshihiro、Yabe Yutaka、Tsuchiya Masahiro、Itaya Nobuyuki、Yoshida Shinichiro、Yano Toshihisa、Sogi Yasuhito、Suzuki Kazuaki、Itoi Eiji
  • Journal Title: Journal of Shoulder and Elbow Surgery Volume: 29 Issue: 1 Pages: 139-145
  • DOI: 10.1016/j.jse.2019.07.004
  • Peer Reviewed / Open Access
• [Journal Article] Association of cleft lip and palate on mother-to-infant bonding: a cross-sectional study in the Japan Environment and Children’s Study (JECS) (2019)
  • Author(s): Tsuchiya Shinobu、Japan Environment & Children’s Study Group、Tsuchiya Masahiro、Momma Haruki、Koseki Takeyoshi、Igarashi Kaoru、Nagatomi Ryoichi、Arima Takahiro、Yaegashi Nobuo
  • Journal Title: BMC Pediatrics Volume: 19 Issue: 1 Pages: 505-505
  • DOI: 10.1186/s12887-019-1877-9
  • Peer Reviewed / Open Access
• [Journal Article] Parents’ Own Experience of Verbal Abuse Is Associated with their Acceptance of Abuse towards Children from Youth Sports Coaches (2019)
  • Author(s): Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kanazawa Kenji、Koide Masashi、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Itoi Eiji、Nagatomi Ryoichi
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 249 Issue: 4 Pages: 249-254
  • DOI: 10.1620/tjem.249.249
  • NAID: 130007761144
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Exercise‐evoked intramuscular neutrophil‐endothelial interactions support muscle performance and GLUT4 translocation: a mouse gnawing model study (2019)
  • Author(s): Chaweewannakorn Chayanit、Nyasha Mazvita R.、Chen Weijian、Sekiai Shigenori、Tsuchiya Masahiro、Hagiwara Yoshihiro、Bouzakri Karim、Sasaki Keiichi、Kanzaki Makoto
  • Journal Title: The Journal of Physiology Volume: 598 Issue: 1 Pages: 101-122
  • DOI: 10.1113/jp278564
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Musculoskeletal pain and new-onset poor physical function in elderly survivors of a natural disaster: a longitudinal study after the great East Japan earthquake (2019)
  • Author(s): Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Onoki Takahiro、Tsuji Ichiro、Itoi Eiji
  • Journal Title: BMC Geriatrics Volume: 19 Issue: 1 Pages: 274-274
  • DOI: 10.1186/s12877-019-1283-z
  • Peer Reviewed / Open Access
• [Journal Article] Association between continued residence in temporary prefabricated housing and musculoskeletal pain in survivors of the Great East Japan Earthquake: a longitudinal study (2019)
  • Author(s): Sogi Yasuhito、Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Sugawara Yumi、Tsuchiya Masahiro、Koide Masashi、Itaya Nobuyuki、Yoshida Shinichirou、Yano Toshihisa、Tsuji Ichiro、Itoi Eiji
  • Journal Title: BMJ Open Volume: 9 Issue: 10 Pages: e030761-e030761
  • DOI: 10.1136/bmjopen-2019-030761
  • Peer Reviewed / Open Access
• [Journal Article] In vitro exercise model using contractile human and mouse hybrid myotubes (2019)
  • Author(s): Chen Weijian、Nyasha Mazvita R.、Koide Masashi、Tsuchiya Masahiro、Suzuki Naoki、Hagiwara Yoshihiro、Aoki Masashi、Kanzaki Makoto
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 11914-11914
  • DOI: 10.1038/s41598-019-48316-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Verbal Abuse from Coaches Is Associated with Loss of Motivation for the Present Sport in Young Athletes: A Cross-Sectional Study in Miyagi Prefecture (2019)
  • Author(s): Yabe Yutaka、Hagiwara Yoshihiro、Sekiguchi Takuya、Momma Haruki、Tsuchiya Masahiro、Kuroki Kaoru、Kanazawa Kenji、Koide Masashi、Itaya Nobuyuki、Yoshida Shinichirou、Sogi Yasuhito、Yano Toshihisa、Itoi Eiji、Nagatomi Ryoichi
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 248 Issue: 2 Pages: 107-113
  • DOI: 10.1620/tjem.248.107
  • NAID: 130007666273
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of inflammasome activation via elevation of uric acid level in nociception in a mouse model of muscle pain (2019)
  • Author(s): Yoshida Shinichirou、Hagiwara Yoshihiro、Tsuchiya Masahiro、Shinoda Masamichi、Koide Masashi、Hatakeyama Hiroyasu、Chaweewannakorn Chayanit、Suzuki Kazuaki、Yano Toshihisa、Sogi Yasuhito、Itaya Nobuyuki、Sekiguchi Takuya、Yabe Yutaka、Sasaki Keiichi、Kanzaki Makoto、Itoi Eiji
  • Journal Title: Molecular Pain Volume: 15 Pages: 1-16
  • DOI: 10.1177/1744806919858797
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High prevalence of toothache among Great East Japan Earthquake survivors living in temporary housing. (2019)
  • Author(s): Tsuchiya M, Aida J, Watanabe T, Shinoda M, Sugawara Y, Tomata Y, Yabe Y, Sekiguchi T, Watanabe M, Osaka K, Sasaki K, Hagiwara Y, Tsuji I.
  • Journal Title: Community Dent Oral Epidemiol. Volume: 47(2) Issue: 2 Pages: 119-126
  • DOI: 10.1111/cdoe.12433
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of catecholaminergic and GABAAergic mediations in the anxiety-related behavior in long-term powdered diet-fed mice. (2019)
  • Author(s): Yaoita F, Tsuchiya M, Arai Y, Tadano T, Tan-No K.
  • Journal Title: Neurochem Int. Volume: 124 Pages: 1-9
  • DOI: 10.1016/j.neuint.2018.12.002
  • Peer Reviewed
• [Journal Article] The characteristics of coaches that verbally and physically abuse young baseball players using a self-reported questionnaire. (2019)
  • Author(s): Hagiwara Y, Sekiguchi T, Yabe Y, Momma H, Tsuchiya M, Kanazawa K, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Itoi E, Nagatomi R.
  • Journal Title: J Orthop Sci. Volume: 24(2) Issue: 2 Pages: 361-367
  • DOI: 10.1016/j.jos.2018.06.024
  • Peer Reviewed
• [Journal Article] Knee pain is associated with lower back pain in young baseball players: a cross-sectional study. (2019)
  • Author(s): Yabe Y, Hagiwara Y, Sekiguchi T, Momma H, Tsuchiya M, Kuroki K, Kanazawa K, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Itoi E, Nagatomi R.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc. Volume: 27(3) Issue: 3 Pages: 985-990
  • DOI: 10.1007/s00167-018-5129-6
  • Peer Reviewed
• [Journal Article] Sleep Disturbance Is Associated with New Onset and Continuation of Lower Back Pain: A Longitudinal Study among Survivors of the Great East Japan Earthquake (2018)
  • Author(s): Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Tsuchiya M, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Tsuji I, Itoi E.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 246 Issue: 1 Pages: 9-14
  • DOI: 10.1620/tjem.246.9
  • NAID: 130007479611
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] Playing video games for more than 3 hours a day is associated with shoulder and elbow pain in elite young male baseball players. (2018)
  • Author(s): Sekiguchi T, Hagiwara Y, Yabe Y, Tsuchiya M, Itaya N, Yoshida S, Yano T, Sogi Y, Suzuki K, Itoi E.
  • Journal Title: J Shoulder Elbow Surg. Volume: 27(9) Issue: 9 Pages: 1629-1635
  • DOI: 10.1016/j.jse.2018.06.005
  • Peer Reviewed
• [Journal Article] Association between trunk pain and lower extremity pain among youth soccer players: a cross-sectional study. (2018)
  • Author(s): Sogi Y, Hagiwara Y, Yabe Y, Sekiguchi T, Momma H, Tsuchiya M, Kuroki K, Kanazawa K, Koide M, Itaya N, Yoshida S, Yano T, Itoi E, Nagatomi R.
  • Journal Title: BMC Sports Sci Med Rehabil. Volume: 10 Issue: 1 Pages: 13-13
  • DOI: 10.1186/s13102-018-0102-8
  • Peer Reviewed
• [Journal Article] Musculoskeletal Pain is Associated With New-Onset Psychological Distress in Survivors of the Great East Japan Earthquake. (2018)
  • Author(s): Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Tsuchiya M, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Tsuji I, Itoi E.
  • Journal Title: Disaster Med Public Health Prep. Volume: - Issue: 02 Pages: 1-6
  • DOI: 10.1017/dmp.2018.57
  • Peer Reviewed
• [Journal Article] Neutrophils Provide a Favorable IL-1-Mediated Immunometabolic Niche that Primes GLUT4 Translocation and Performance in Skeletal Muscles. (2018)
  • Author(s): Tsuchiya M, Sekiai S, Hatakeyama H, Koide M, Chaweewannakorn C, Yaoita F, Tan-No K, Sasaki K, Watanabe M, Sugawara S, Endo Y, Itoi E, Hagiwara Y, Kanzaki M.
  • Journal Title: Cell Rep. Volume: 23(8) Pages: 2354-2364
  • Peer Reviewed
• [Journal Article] Comparative proteome analysis of the capsule from patients with frozen shoulder. (2018)
  • Author(s): Hagiwara Y, Mori M, Kanazawa K, Ando A, Yabe Y, Koide M, Sekiguchi T, Itaya N, Tsuchiya M, Itoi E.
  • Journal Title: J Shoulder Elbow Surg. Volume: 27(10) Issue: 10 Pages: 1770-1778
  • DOI: 10.1016/j.jse.2018.03.010
  • Peer Reviewed
• [Journal Article] The Characteristics of Coaches that Verbally or Physically Abuse Young Athletes (2018)
  • Author(s): Yabe Y, Hagiwara Y, Sekiguchi T, Momma H, Tsuchiya M, Kuroki K, Kanazawa K, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Itoi E, Nagatomi R.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 244 Issue: 4 Pages: 297-304
  • DOI: 10.1620/tjem.244.297
  • NAID: 130006682574
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] Effects of Low-Intensity Pulsed Ultrasound for Preventing Joint Stiffness in Immobilized Knee Model in Rats. (2018)
  • Author(s): Itaya N, Yabe Y, Hagiwara Y, Kanazawa K, Koide M, Sekiguchi T, Yoshida S, Sogi Y, Yano T, Tsuchiya M, Saijo Y, Itoi E.
  • Journal Title: Ultrasound Med Biol. Volume: - Issue: 6 Pages: 1244-1256
  • DOI: 10.1016/j.ultrasmedbio.2018.02.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Roles of IL-1α/β in regeneration of cardiotoxin-injured muscle and satellite cell function (2018)
  • Author(s): Chaweewannakorn Chayanit、Tsuchiya Masahiro、Koide Masashi、Hatakeyama Hiroyasu、Tanaka Yukinori、Yoshida Shinichirou、Sugawara Shunji、Hagiwara Yoshihiro、Sasaki Keiichi、Kanzaki Makoto
  • Journal Title: Am. J. Physiol. Regul. Integr. Comp. Physiol. Volume: 印刷中 Issue: 1 Pages: R90-R103
  • DOI: 10.1152/ajpregu.00310.2017
  • Peer Reviewed
• [Journal Article] Yoshida S, Hagiwara Y, Tsuchiya M, Shinoda M, Koide M, Hatakeyama H, Chaweewannakorn C, Yano T, Sogi Y, Itaya N, Sekiguchi T, Yabe Y, Sasaki K, Kanzaki M, Itoi E. (2018)
  • Author(s): Involvement of neutrophils and interleukin-18 in nociception in a mouse model of muscle pain.
  • Journal Title: Mol Pain. Volume: －
  • DOI: 10.1177/1744806918757286
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep. (2018)
  • Author(s): Yaoita F, Muto M, Murakami H, Endo S, Kozawa M, Tsuchiya M, Tadano T, Tan-No K.
  • Journal Title: Physiol Behav. Volume: 186 Pages: 52-61
  • DOI: 10.1016/j.physbeh.2018.01.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Higher Incidence of Sleep Disturbance among Survivors with Musculoskeletal Pain after the Great East Japan Earthquake: A Prospective Study (2018)
  • Author(s): Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Tsuchiya M, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Tsuji I, Itoi E.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 244 Issue: 1 Pages: 25-32
  • DOI: 10.1620/tjem.244.25
  • NAID: 130006307431
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Retained Myogenic Potency of Human Satellite Cells from Torn Rotator Cuff Muscles Despite Fatty Infiltration (2018)
  • Author(s): Koide M, Hagiwara Y, Tsuchiya M, Kanzaki M, Hatakeyama H, Tanaka Y, Minowa T, Takemura T, Ando A, Sekiguchi T, Yabe Y, Itoi E.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 244 Issue: 1 Pages: 15-24
  • DOI: 10.1620/tjem.244.15
  • NAID: 130006287941
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Factors associated with sports-related dental injuries among young athletes: a cross-sectional study in Miyagi prefecture. (2017)
  • Author(s): Tsuchiya S, Tsuchiya M, Momma H, Sekiguchi T, Kuroki K, Kanazawa K, Koseki T, Igarashi K, Nagatomi R, Hagiwara Y.
  • Journal Title: BMC Oral Health. Volume: 17 Issue: 1 Pages: 168-168
  • DOI: 10.1186/s12903-017-0466-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Excessive game playing is associated with musculoskeletal pain among youth athletes: a cross-sectional study in Miyagi prefecture. (2017)
  • Author(s): Sekiguchi T, Hagiwara Y, Momma H, Tsuchiya M, Kuroki K, Kanazawa K, Yabe Y, Yoshida S, Koide M, Itaya N, Itoi E, Nagatomi R.
  • Journal Title: J Sports Sci. Volume: 22 Issue: 16 Pages: 1-7
  • DOI: 10.1080/02640414.2017.1420453
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Coexistence of Trunk or Lower Extremity Pain with Elbow and/or Shoulder Pain among Young Overhead Athletes: A Cross-Sectional Study (2017)
  • Author(s): Sekiguchi T, Hagiwara Y, Momma H, Tsuchiya M, Kuroki K, Kanazawa K, Yabe Y, Yoshida S, Koide M, Itaya N, Itoi E, Nagatomi R.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 243 Issue: 3 Pages: 173-178
  • DOI: 10.1620/tjem.243.173
  • NAID: 130006210076
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between sleep disturbance and new-onset subjective knee pain in Great East Japan Earthquake survivors: A prospective cohort study in the Miyagi prefecture. (2017)
  • Author(s): Hagiwara Y, Sekiguchi T, Sugawara Y, Yabe Y, Koide M, Itaya N, Yoshida S, Sogi Y, Tsuchiya M, Tsuji I, Itoi E.
  • Journal Title: J Orthop Sci. Volume: 23 Issue: 2 Pages: 334-340
  • DOI: 10.1016/j.jos.2017.10.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Induction of the Histamine-Forming Enzyme Histidine Decarboxylase in Skeletal Muscles by Prolonged Muscular Work: Histological Demonstration and Mediation by Cytokines (2017)
  • Author(s): Ayada K, Tsuchiya M, Yoneda H, Yamaguchi K, Kumamoto H, Sasaki K, Tadano T, Watanabe M, Endo Y.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 40 Issue: 8 Pages: 1326-1330
  • DOI: 10.1248/bpb.b17-00112
  • NAID: 130005876320
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association Between Sleep Disturbance and New-onset Subjective Shoulder Pain in Survivors of the Great East Japan Earthquake: A Prospective Cohort Study in Miyagi Prefecture (2017)
  • Author(s): Hagiwara Y, Sekiguchi T, Sugawara Y, Yabe Y, Koide M, Itaya N, Yoshida S, Sogi Y, Tsuchiya M, Tsuji I, Itoi E.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 242 Issue: 3 Pages: 193-201
  • DOI: 10.1620/tjem.242.193
  • NAID: 130005745351
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Late bedtimes, short sleeping time, and longtime video-game playing are associated with low back pain in school-aged athletes. (2017)
  • Author(s): Yabe Y, Hagiwara Y, Sekiguchi T, Momma H, Tsuchiya M, Kuroki K, Kanazawa K, Koide M, Itaya N, Itoi E, Nagatomi R.
  • Journal Title: Eur Spine J. Volume: - Issue: 5 Pages: 1112-1118
  • DOI: 10.1007/s00586-017-5177-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Excessive Game Playing Is Associated with Poor Toothbrushing Behavior among Athletic Children: A Cross-Sectional Study in Miyagi, Japan (2017)
  • Author(s): Tsuchiya M, Momma H, Sekiguchi T, Kuroki K, Kanazawa K, Watanabe M, Hagiwara Y, Nagatomi R.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 241 Issue: 2 Pages: 131-138
  • DOI: 10.1620/tjem.241.131
  • NAID: 130005332357
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Living status, economic hardship and sleep disturbance were associated with subjective shoulder pain in survivors of the Great East Japan Earthquake: A cross sectional study. (2017)
  • Author(s): Hagiwara Y, Sekiguchi T, Yabe Y, Sugawara Y, Watanabe T, Kanazawa K, Koide M, Itaya N, Tsuchiya M, Tsuji I, Itoi E.
  • Journal Title: J Orthop Sci. Volume: 印刷中 Issue: 3 Pages: 442-446
  • DOI: 10.1016/j.jos.2016.12.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inflammatory Effects of Nitrogen-Containing Bisphosphonates (N-BPs): Modulation by Non-N-BPs (2017)
  • Author(s): Shima K, Tsuchiya M, Oizumi T, Takano-Yamamoto T, Sugawara S, Endo Y.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 40 Issue: 1 Pages: 25-33
  • DOI: 10.1248/bpb.b16-00521
  • NAID: 130005188786
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of living environment and subjective economic hardship on new-onset of low back pain for survivors of the Great East Japan Earthquake. (2017)
  • Author(s): Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Sato M, Kanazawa K, Koide M, Itaya N, Tsuchiya M, Tsuji I, Itoi E.
  • Journal Title: J Orthop Sci. Volume: 22 Issue: 1 Pages: 43-49
  • DOI: 10.1016/j.jos.2016.11.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Transfer of the bone morphogenetic protein 4 gene into rat periodontal ligament by in vivo electroporation (2016)
  • Author(s): Tsuchiya S, Chiba M, Kishimoto KN, Nakamura H, Tsuchiya M, Hayashi H
  • Journal Title: Archives of Oral Biology Volume: 74 Pages: 123-132
  • DOI: 10.1016/j.archoralbio.2016.11.013
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Youth baseball players with elbow and shoulder pain have both low back and knee pain: a cross-sectional study. (2016)
  • Author(s): Sekiguchi T, Hagiwara Y, Momma H, Tsuchiya M, Kuroki K, Kanazawa K, Yabe Y, Koide M, Itaya N, Itoi E, Nagatomi R.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc. Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of methylphenidate on the impairment of spontaneous alternation behavior in mice intermittently deprived of REM sleep. (2016)
  • Author(s): Fukie Niijima-Yaoita、Yuka Nagasawa、Masahiro Tsuchiya、Yuichiro Arai、Takeshi Tadano、Koichi Tan-No
  • Journal Title: Neurochem. Int. Volume: 100巻 Pages: 128-137
  • DOI: 10.1016/j.neuint.2016.09.010
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Strategy against the Osteonecrosis of the Jaw Associated with Nitrogen-Containing Bisphosphonates (N-BPs): Attempts to Replace N-BPs with the Non-N-BP Etidronate (2016)
  • Author(s): Oizumi T, Yamaguchi K, Sato K, Okada S, Suzuki H, Funayama H, Mori S, Nagasaka H, Tsuchiya M, Hagiwara W, Itoi E, Sugawara S, Takahashi T, Endo Y:
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 9 Pages: 1549-1554
  • DOI: 10.1248/bpb.b16-00041
  • NAID: 130005262320
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways (2016)
  • Author(s): Shima K, Nemoto W, Tsuchiya M, Tan-No K, Takano-Yamamoto T, Sugawara S, Endo Y.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 5 Pages: 770-777
  • DOI: 10.1248/bpb.b15-00882
  • NAID: 130005149271
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phosphonocarboxylates Can Protect Mice against the Inflammatory and Necrotic Side Effects of Nitrogen-Containing Bisphosphonates by Inhibiting Their Entry into Cells <i>via</i> Phosphate Transporters (2016)
  • Author(s): Kiyama T, Tsuchiya M, Okada S, Oizumi T, Yamaguchi K, Sasaki K, Sugawara S, Endo Y.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 5 Pages: 712-720
  • DOI: 10.1248/bpb.b15-00770
  • NAID: 130005149275
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analgesic Effects of 1st Generation Anti-histamines in Mice (2016)
  • Author(s): Mebae Takahashi, Kazuhiro Shima, Masahiro Tsuchiya, Yoshihiro Hagiwara, Hirokazu Mizoguchi, Shinobu Sakurada, Shunji Sugawara, Takuo Fujita, Takeshi Tadano, Makoto Watanabe, Satoshi Fukumoto, Yasuo Endo
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 4 Pages: 620-624
  • DOI: 10.1248/bpb.b15-00755
  • NAID: 130005141684
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of living environments and working status on low back pain for survivors of the Great East Japan Earthquake. (2016)
  • Author(s): Hagiwara Y, Yabe Y, Sugawara Y, Sato M, Watanabe T, Kanazawa K, Sonofuchi K, Koide M, Sekiguchi T, Tsuchiya M, Tsuji I, Itoi E.
  • Journal Title: J Orthop Sci. Volume: 21 Issue: 2 Pages: 138-142
  • DOI: 10.1016/j.jos.2015.12.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Decreased elastic fibers and increased proteoglycans in the ligamentum flavum of patients with lumbar spinal canal stenosis. (2016)
  • Author(s): Yabe Y, Hagiwara Y, Tsuchiya M, Honda M, Hatori K, Sonofuchi K, Kanazawa K, Koide M, Sekiguchi T, Itaya N, Itoi E.
  • Journal Title: J Orthop Res. Volume: 34 Issue: 7 Pages: 1241-1247
  • DOI: 10.1002/jor.23130
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 食事を生涯楽しむための 健口(けんこう)生活 (2019)
  • Author(s): 土谷 昌広
  • Organizer: 歯と健康のつどい
  • Invited
• [Presentation] 東日本大震災後の歯痛罹患と住居形態に関する検討 (2019)
  • Author(s): 土谷昌広,相田潤,渡邉崇,篠田雅路,菅原由美,遠又靖丈,矢部裕,関口拓矢,渡邉誠,小坂健,佐々木啓一,萩原嘉廣,辻一郎
  • Organizer: 第41回日本疼痛学会
• [Presentation] お口と健康 2019 (2019)
  • Author(s): 土谷 昌広
  • Organizer: 東北福祉大学公開講座
  • Invited
• [Presentation] 在宅療養歯科支援診療所 及びかかりつけ強化型歯科診療所 届出に関する心得 (2019)
  • Author(s): 土谷 昌広
  • Organizer: 仙台歯科医師会 施設基準届出に係る講習会
  • Invited
• [Presentation] 東日本大震災後のプレハブ仮設居住者における歯痛罹患に関する検討 (2019)
  • Author(s): 土谷昌広,渡部芳彦,渡邉 誠,佐々木啓一
  • Organizer: 日本補綴歯科学会第128回学術大
• [Presentation] スポーツ関連外傷歯既往の関連因子に関するの検討：宮城県スポーツ少年団団員の横断調査 (2019)
  • Author(s): 土谷昌広,土谷忍
  • Organizer: 日本口腔科学会第73会学術集会
• [Presentation] Joint Hemorrhage Accelerates Cartilage Degeneration In A Rat Immobilized Knee Model. (2019)
  • Author(s): Sogi Y, Hagiwara Y, Yabe Y, Tsuchiya M, Chimoto E, Onoda Y, Sekiguchi T, Itaya N, Yoshida S, Yano T, Suzuki K, Itoi E.
  • Organizer: ORS 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Involvement of neutrophils and interleukin-18 in nociception in a mouse model of muscle pain. (2018)
  • Author(s): Yoshida S, Hagiwara Y, Tsuchiya M, Shinoda M, Koide M, Hatakeyama H, Chaweewannakorn C, Yano T, Sogi Y, Itaya N, Sekiguchi T, Yabe Y, Sasaki K, Kanzaki M, Itoi E
  • Organizer: The 17th WORLD CONGRESS ON PAIN
  • Int'l Joint Research
• [Presentation] 筋機能時における好中球由来IL1βの役割 (2018)
  • Author(s): 土谷 昌広，Chayanit Chaweewannakorn，佐々木 啓一，菅 原 俊二，渡邉 誠，遠藤 康男
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] マウス筋機械痛覚過敏に対するIL-18の関与 (2018)
  • Author(s): 土谷 昌広, 吉田 新一郎, 萩原 嘉廣, 篠田 雅路, 小出 将志, 畠山 裕康, チャウイワンナコン・チャヤニ, 矢野 利尚, 曽木 靖仁, 板谷 信行, 関口 拓矢, 矢部 裕, 土谷 忍, 佐々木 啓一, 神崎 展, 井樋 栄二.
  • Organizer: 第40回日本疼痛学会
• [Presentation] 長期粉末食飼育がマウスの情動発達に及ぼす影響について (2018)
  • Author(s): 八百板富紀枝，今泉宏紀，川浪啓豪，土谷昌広，只野 武，丹野孝一
  • Organizer: 日本薬学会第138年会
• [Presentation] Roles of Interleukin-1 in mediating the skeletal muscle activity (2017)
  • Author(s): Chaweewannakorn C, Tsuchiya M, Kanzaki M, Hagiwara Y, Hatakeyama H, Koide M, Yoshida S, Sasaki K
  • Organizer: the 17th Asian Academy of Craniomandibular Disorders
  • Int'l Joint Research
• [Presentation] Roles of Interlukin-1 in the regulation of myoblast fusion and actin dynamics (2017)
  • Author(s): Chaweewannakorn C, Hatakeyama H, Tsuchiya M, Hagiwara Y, Koide M, Yoshida S, Kanzaki M, Sasaki K.
  • Organizer: 2017 American Society for Cell Biology (ASCB) | European Molecular Biology Organization (EMBO) Meeting
  • Int'l Joint Research
• [Presentation] 高齢者施設における経口維持加算対象者のアセスメントと常勤歯科衛生士の役割 (2017)
  • Author(s): 秋山利津子、土谷 昌広、渡部 芳彦
  • Organizer: 日本老年歯科医学会第28回学術大会
• [Presentation] 介護保険施設に常勤する歯科衛生士のあり方の考察 (2017)
  • Author(s): 片桐美由紀、渡部芳彦、秋山利津子、土谷昌広
  • Organizer: 日本老年歯科医学会第28回学術大会
• [Presentation] 粉末食を用いた長期飼育がマウスの糖代謝機構へ及ぼす影響 (2017)
  • Author(s): 土谷忍、土谷昌広、佐々木啓一、渡邉誠
  • Organizer: 第71回日本口腔科学会学術集会
• [Presentation] 東日本大震災被災者における歯周病と不眠症の関連 (2017)
  • Author(s): 土谷昌広，渡邉誠
  • Organizer: 第71回日本口腔科学会学術集会
• [Presentation] 筋機能発現における好中球の産生するIL1βの糖代謝調節機構 (2017)
  • Author(s): 土谷昌広,チャヤニチャウィワンナコン,佐々木啓一,渡部芳彦,渡邉 誠
  • Organizer: 日本補綴歯科学会第126回学術大会
• [Presentation] 腰部脊柱管狭窄症の肥厚した黄色靭帯における弾性線維とプロテオグリカンの解析． (2016)
  • Author(s): 矢部裕、萩原嘉廣、土谷昌広、本田雅人、金澤憲治、小出将志、関口拓矢、板谷信行、井樋栄二．
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡市博多区）
  • Year and Date: 2016-10-13
• [Presentation] 廃用萎縮・脂肪変性した筋組織中の筋・脂肪前駆細胞の分化能の評価． (2016)
  • Author(s): 小出将志、矢部裕、萩原嘉廣、土谷昌広、本田雅人、金澤憲治、関口拓矢、板谷信行、井樋栄二．
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡市博多区）
  • Year and Date: 2016-10-13
• [Presentation] 介護福祉領域における歯科衛生士の連携に関する研究． (2016)
  • Author(s): 渡部芳彦、秋山（若生）利津子、小林淑子、田中英子、片桐美由紀、岸さやか、堀越省子、渡部千代、人見早苗、土谷昌広
  • Organizer: 日本歯科衛生学会第11回学術大会
  • Place of Presentation: 広島国際会議場（広島県広島市）
  • Year and Date: 2016-09-17
• [Presentation] 東日本大震災被災者における歯周病と不眠症の関連． (2016)
  • Author(s): 土谷昌広，萩原嘉廣，渡部芳彦，渡邉誠．
  • Organizer: 日本補綴歯科学会第125回学術大会．
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2016-07-08
• [Presentation] Expression of umami taste-related genes in the tongue: a pilot study for genetic taste diagnosis. (2016)
  • Author(s): Noriaki Shoji*, Shizuko Satoh-Kuriwada, Masahiro Tsuchiya, Hisayuki Uneyama, Misako Kawai, and Takashi Sasano
  • Organizer: 17th International symposium on olfaction and Taste.
  • Place of Presentation: Pacifico Yokohama (Yokohama)
  • Year and Date: 2016-06-05
  • Int'l Joint Research / Invited
• [Book] 福祉・保健・医療のための栄養ケア入門 : 多職種連携の栄養学 (2019)
  • Author(s): 渡辺, 早苗, 寺本, 房子, 石山, 麗子, 小坂, 和江, 五味, 郁子, 土谷, 昌広, 細山田, 洋子
  • Total Pages: 154
  • Publisher: 建帛社
  • ISBN: 9784767933863
• [Book] 健康と医療福祉のための栄養学 身体のしくみと栄養素の働きを理解する (2018)
  • Author(s): 渡邉 早苗, 寺本 房子, 松谷 美和子, 土谷 昌広, 小野 若菜子
  • Total Pages: 224
  • Publisher: 医歯薬出版
  • ISBN: 9784263707371