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Molecular biological search for non-infectiously induced peri-implant bone resorption

Research Project

Project/Area Number 16K11585
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTohoku University

Principal Investigator

Ishibashi MInoru  東北大学, 歯学研究科, 助教 (40231138)

Co-Investigator(Kenkyū-buntansha) 江草 宏  東北大学, 歯学研究科, 教授 (30379078)
山田 将博  東北大学, 歯学研究科, 准教授 (90549982)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsOcclusal Overloading / Saucerization / 破骨細胞 / 骨芽細胞 / 骨細胞 / インプラント周囲組織 / 免疫染色 / 脱灰切片 / 非感染性骨吸収 / 分子生物学 / 動物実験モデル / 骨細胞由来の機構 / 軟組織由来の機構
Outline of Final Research Achievements

The present study purposed to establish an animal experimental model of non-infectious peri-implant bone resorption and to explore its molecular biological mechanism. First, Staphylococcus aureus strains were cultured on various titanium disks to identify the implant surface property with low infection sensitivity. It was found that smooth surface or nano-rough surface had lower infection sensitivity than micro-rough surface.
Next, the influences of oxidative stress associated with noninfectious bone resorption on bone healing were examined. As a result, oxidative stress induced apoptosis and senescence in mesenchymal stem cells and hence, significantly inhibited bone healing. In contrast, conditioning of mesenchymal stem cells with an antioxidant suppressed induction of apoptosis and promoted bone regeneration after cell local transplantation into a bone defect.

Academic Significance and Societal Importance of the Research Achievements

非感染性インプラント周囲骨吸収はインプラントの生存だけでなく,インプラント補綴の審美性や清掃性を損なうため,その術前診断と予防法の確立は重要な臨床的課題の一つである.本研究成果の学術的な特色は,インプラント周囲骨吸収病態解明研究上の障壁を的確に捉え,最新の細胞生物学的知見と組織学的および分子生物学的解析を駆使して,未知であった非感染性インプラント周囲骨吸収の病態を探索し,重要な臨床的課題に解決の糸口を与えた点である.そのため,歯科補綴学の医学的レベルを向上させ,生体材料学ならびに分子細胞生物学の発展にも貢献し得る意義深い成果を得たと考えられる.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 Other

All Journal Article (10 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 5 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress2018

    • Author(s)
      Watanabe Jun、Yamada Masahiro、Niibe Kunimichi、Zhang Maolin、Kondo Takeru、Ishibashi Minoru、Egusa Hiroshi
    • Journal Title

      Biomaterials

      Volume: 185 Pages: 25-38

    • DOI

      10.1016/j.biomaterials.2018.08.055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of osteoblastic function on titanium surface with titanium-doped hydroxyapatite nano-particle coating: an in vitro study.2017

    • Author(s)
      Nakazawa M, Yamada M, Wakamatsu M, Egusa H, Sakurai K.
    • Journal Title

      Int J Oral Maxillofac Implants.

      Volume: in press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Notch signaling partly regulates the osteogenic differentiation of retinoic acid-treated murine induced pluripotent stem cells.2017

    • Author(s)
      Osathanon T, Manokawinchoke J, Egusa H, Pavasant P.
    • Journal Title

      J Oral Sci

      Volume: 印刷中

    • NAID

      130006077653

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Novel antioxidant capability of titanium induced by UV light treatment.2016

    • Author(s)
      Ueno T, Ikeda T, Tsukimura N, Ishijima M, Minamikawa H, Sugita Y, Yamada M, Wakabayashi N, Ogawa T.
    • Journal Title

      Biomaterials.

      Volume: 108 Pages: 177-186

    • DOI

      10.1016/j.biomaterials.2016.08.050

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Fabric of the modern implantology 光機能化の臨床研究による証明 光機能化によりオッセオインテグレーションは加速するのか、増強するのか、それとも両方か2016

    • Author(s)
      小川隆広, 丹野 努, 船登彰芳, 山田将博, 吉松繁人, 石川 亮, 藍 浩之, 鈴木健造, 中川雅裕, 神津 聡.
    • Journal Title

      歯界展望

      Volume: 127 Pages: 734-744

    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Journal Article] The Fabric of the modern implantology 光機能化チタンメッシュ応用 GBR2016

    • Author(s)
      小川隆広, 藍 浩之, 船登彰芳, 山田将博, 吉松繁人, 丹野 努, 石川 亮, 鈴木健造, 中川雅裕, 神津 聡. 鈴木健造.
    • Journal Title

      歯界展望

      Volume: 127 Pages: 926-939

    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Journal Article] The Fabric of the modern implantology インプラント周囲上皮性付着の強化に向けた補綴戦略2016

    • Author(s)
      山田将博, 藍 浩之, 鈴木健造, 中川雅裕,石川 亮, 丹野 努, 神津 聡, 吉松繁人, 小川隆広, 船登彰芳.
    • Journal Title

      歯界展望

      Volume: 127 Pages: 1140-1151

    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Journal Article] The Fabric of the modern implantology 予後からみたインプラント治療が抱える課題2016

    • Author(s)
      船登彰芳, 吉松繁人, 藍 浩之, 鈴木健造, 山田将博, 中川雅裕, 石川 亮, 丹野 努, 神津 聡, 小川隆広.
    • Journal Title

      歯界展望

      Volume: 128 Pages: 104-120

    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Hypoxia enhances osteogenic differentiation in retinoic acid-treated murine induced pluripotent stem cells.2016

    • Author(s)
      Manokawinchoke J, Osathanon T, Egusa H, Pavasant P.
    • Journal Title

      Tissue Eng Regen Med

      Volume: 13(5) Pages: 547-553

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 再生歯科医療の動向と展望2016

    • Author(s)
      江草 宏
    • Journal Title

      大阪口腔インプラント研究会

      Volume: 29 Pages: 2-7

    • Related Report
      2016 Research-status Report
  • [Presentation] Redox Biology-Based Preconditioning of MCSs to Assist Bone Regeneration2018

    • Author(s)
      Jun Watanabe, Masahiro Yaada, Kunimichi Niibe, Taakeru Kondo and Hiroshi Egusa
    • Organizer
      96th General session & Exhiition of the IADR
    • Related Report
      2018 Annual Research Report
  • [Presentation] Redox biology-based strategy in bone regeneration for efficient transplantation of osteoblastic cells.2017

    • Author(s)
      1.Watanabe J, Yamada M, Egusa H.
    • Organizer
      International meeting the 7th Temu Ilmiah Nasional and 4th Scientific Meeting in Dentistry,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] インプラント表面性状の解釈とその骨結合能を推測する方法2017

    • Author(s)
      山田将博
    • Organizer
      平成29年度(公社)日本補綴歯科学会 東北・北海道支部学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] N-acetyl-L-cysteine Reinforces Apoptosis Resistance of MSCs to Promote Bone Regeneration.2017

    • Author(s)
      Watanabe J, Yamada M, Egusa H.
    • Organizer
      Hatton competition in Japanese Association for Dental Research 65th Annual Meeting
    • Related Report
      2017 Research-status Report
  • [Presentation] 歯根セメント質表面の微小硬度と表面形態の評価2017

    • Author(s)
      山田将博、吉岡勇人、新野秀憲、江草 宏
    • Organizer
      平成29年度生体医歯工学共同研究拠点成果報告会
    • Related Report
      2017 Research-status Report
  • [Presentation] チタンナノ表面が人歯根膜細胞分化に及ぼす効果2017

    • Author(s)
      山田将博, 江草 宏, 吉岡勇人, 新野秀憲.
    • Organizer
      平成28年度生体医歯工学共同研究拠点成果報告会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] Preconditioning of marrow stromal cells for autologous stem cell trnsplantation to enhance bone regeneration.2016

    • Author(s)
      Watanabe J, Yamada M, Egusa H.
    • Organizer
      The 11th international workshop on biomaterials in Interface Science
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Preconditioning strategy for bone regeneration in autologous bone marrow stromal cell transplantation.2016

    • Author(s)
      Yamada M.
    • Organizer
      China-Japan Korea Dental Science Symposium 20116
    • Place of Presentation
      Fuzhou, Cina
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] The Fabric of the Modern Implantology 近代インプラント治療のテクニックとサイエンス2017

    • Author(s)
      船登彰芳,山田将博,吉松繁人(編著)(分担執筆)
    • Total Pages
      240
    • Publisher
      医歯薬出版株式会社
    • ISBN
      9784263461358
    • Related Report
      2017 Research-status Report
  • [Remarks]

    • URL

      http://crbr.dent.tohoku.ac.jp/index.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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