| Project/Area Number |
16K11590
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
窪木 拓男 岡山大学, 医歯薬学総合研究科, 教授 (00225195)
大野 彩 (木村彩) 岡山大学, 大学病院, 助教 (20584626)
大野 充昭 岡山大学, 医歯薬学総合研究科, 助教 (60613156)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 要介護高齢者 / 低栄養 / 腸内エコシステム / 腸内細菌叢 / 16SRNA解析 / 低栄養高齢者 / 16SrRNA解析 / 口腔内細菌叢 / メタゲノム解析 / 歯科補綴学一般 |
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| Outline of Final Research Achievements |
The results of comprehensive analyses of the intestinal flora and metabolites in the elderly requiring long-term care showed that the ratio of bacterial flora X and Y, at the division level, were significantly higher in overweight and underweight individuals, respectively. At the genus level, the bacterial flora Z and A were identified, respectively, as a bacterium positively and negatively correlated with BMI. Moreover, it became clear that some samples of underweight individuals could be distributed in the same cluster.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により，高齢者の栄養不良と腸内細菌叢との関連の詳細が明らかになれば，腸内細菌叢にアプローチする新たな栄養改善療法の開発につながる可能性がある．さらに，口腔内細菌叢と腸内細菌叢の関連が明らかになれば，口腔内細菌叢をバイオマーカーとして栄養不良リスクの高い高齢者を検出し，早期介入を行う有効な手法となり得ることが推測され，超高齢社会における本邦の医療・介護の両面において大きく貢献できると考える．
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