| Project/Area Number |
16K11606
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西村 正宏 鹿児島大学, 医歯学域歯学系, 教授 (00294570)
石井 正和 鹿児島大学, 医歯学域歯学系, 助教 (00456683)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インプラント / 骨 / 骨補填材 / 骨造成 / 歯学 / 再生医学 |
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| Outline of Final Research Achievements |
Implant treatment is an option for defect treatment, but bone loss is a local problem. There are various bone grafting materials, but all have advantages and disadvantages, and artificial bones that are more easily replaced with bones are needed. In this study, carbonated apatite with three-dimensional communicating pores and statin-added type carbonated apatite were inserted and measured, and it was found that the formation of new bone was observed, and those to which statin was added promoted bone replacement. showed that. In addition, statins were not harmful to organs. The tissue skeleton was made using polylactic acid for the 3 dimensional release, but it is necessary to make a more biologically similar structure.
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| Academic Significance and Societal Importance of the Research Achievements |
インプラントに対するニーズが高まるにつれ、インプラント治療をより安全かつ、低侵襲で行う必要性があるが、骨が不足している場合が多いため、骨を増やす必要性があるが、自分の骨では侵襲が大きくなることが多い．より低侵襲に行うためには骨に変化しやすい人工骨が必要であるが、炭酸アパタイトは骨に置換しやすい人工骨であり，骨形成を促進すると言われるスタチンを添加することでより早期に骨に置換するため、安全に治療期間を短縮し、骨を形成する可能性があることが示された．
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