The sleepiness effect of oral care

• Project/Area Number: 16K11611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tohoku Fukushi University
• Principal Investigator: Watanabe Makoto 東北福祉大学, 総合福祉学科, 教授 (80091768)
• Co-Investigator(Kenkyū-buntansha): 土谷 昌広 東北福祉大学, 健康科学部, 准教授 (60372322) ; 萩原 嘉廣 東北大学, 医学系研究科, 准教授 (90436139) ; 水野 康 東北福祉大学, 教育学部, 准教授 (40261789)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 咀嚼 / ブラキシズム / 口腔機能 / 口腔ケア / 歯周病 / 睡眠障害 / ストレス / 慢性痛疾患 / 精神的ストレス / 睡眠 / 痛み

Outline of Final Research Achievements

Sleep is a very important basis for maintaining mental and physical health, and sleep disorders generally tend to exacerbate mental and physical disorders. As shown in the oral environment, high prevalence of periodontal disease has been reported in sleep disorder patients. However, there are many questions about the causal-relationships. From the results of a large-scale disaster health survey, we have shown that periodontal disease are strongly correlated wit h prevalence of insomnia. Although the causal relationship between them is finally unknown, our study suggested that the specialized oral care intervention conducted in the nursing home might support that the improvement and maintenance of the oral health status would lead to the qualitative improvement of sleep. Therefore, it is considered that the effectiveness of dental intervention for sleep disorder patients was shown.

Academic Significance and Societal Importance of the Research Achievements

睡眠の問題は心身共に直接的に疾患へと繋がるリスクが高く，その慢性化はQOLを大きく低下させる．歯周病も成人の８割が罹患するとされており、睡眠と同様に国民病と言える状況である．これら二つの疾患はともにself-management（生活習慣や健康行動の自己管理）に因る部分が大きく，我が国の抱える医療費問題からもその重要性は高まる一方である．
本研究結果から示される，口腔疾患と睡眠障害の密接な関係，そして睡眠障害治療における新しい選択肢の一つとしての歯科医療の提示は，睡眠障害の発症メカニズム解明の一助となり，臨床的にきわめて意義のある研究であるといえる．

Research Products

• [Journal Article] Dental Status is Associated With Incident Functional Disability in Community-Dwelling Older Japanese: A Prospective Cohort Study Using Propensity Score Matching (2020)
  • Author(s): Takamasa Komiyama, Takashi Ohi, Yasutake Tomata, Fumiya Tanji, Ichiro Tsuji, Makoto Watanabe, Yoshinori Hattori
  • Journal Title: Journal of Epidemiology Volume: 30 Issue: 2 Pages: 84-90
  • DOI: 10.2188/jea.JE20180203
  • NAID: 130007795073
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-02-05
  • Peer Reviewed / Open Access
• [Journal Article] Maximum Occlusal Force and Incident Functional Disability in Older Adults: The Tsurugaya Project. (2018)
  • Author(s): Ohi T, Komiyama T, Miyoshi Y, Murakami T, Tsuboi A, Tomata Y, Tsuji I, Watanabe M, Hattori Y.
  • Journal Title: JDR Clinical & Translational Research Volume: 3(2)
  • Peer Reviewed
• [Journal Article] Relationship between status of dentition and incident functional disability in an elderly Japanese population: prospective cohort study of the Tsurugaya project (2018)
  • Author(s): Komiyama Takamasa、Ohi Takashi、Miyoshi Yoshitada、Murakami Takahisa、Tsuboi Akito、Tomata Yasutake、Tsuji Ichiro、Watanabe Makoto、Hattori Yoshinori
  • Journal Title: Journal of Prosthodontic Research Volume: 62 Issue: 4 Pages: 443-448
  • DOI: 10.1016/j.jpor.2018.04.003
  • NAID: 130007521608
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed
• [Journal Article] Neutrophils Provide a Favorable IL-1-Mediated Immunometabolic Niche that Primes GLUT4 Translocation and Performance in Skeletal Muscles (2018)
  • Author(s): Tsuchiya Masahiro、Sekiai Shigenori、Hatakeyama Hiroyasu、Koide Masashi、Chaweewannakorn Chayanit、Yaoita Fukie、Tan-No Koichi、Sasaki Keiichi、Watanabe Makoto、Sugawara Shunji、Endo Yasuo、Itoi Eiji、Hagiwara Yoshihiro、Kanzaki Makoto
  • Journal Title: Cell Reports Volume: 23 Issue: 8 Pages: 2354-2364
  • DOI: 10.1016/j.celrep.2018.04.067
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of masticatory muscle coordination during unilateral single-tooth clenching using muscle functional magnetic resonance imaging. (2018)
  • Author(s): Yamaguchi S, Okada C, Watanabe Y, Watanabe M, Hattori Y.
  • Journal Title: J Oral Rehabil. Volume: 45 Issue: 1 Pages: 9-16
  • DOI: 10.1111/joor.12583
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of Low-Intensity Pulsed Ultrasound for Preventing Joint Stiffness in Immobilized Knee Model in Rats. (2018)
  • Author(s): Itaya N, Yabe Y, Hagiwara Y, Kanazawa K, Koide M, Sekiguchi T, Yoshida S, Sogi Y, Yano T, Tsuchiya M, Saijo Y, Itoi E.
  • Journal Title: Ultrasound Med Biol. Volume: - Issue: 6 Pages: 1244-1256
  • DOI: 10.1016/j.ultrasmedbio.2018.02.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep. (2018)
  • Author(s): Yaoita F, Muto M, Murakami H, Endo S, Kozawa M, Tsuchiya M, Tadano T, Tan-No K.
  • Journal Title: Physiol Behav. Volume: 186 Pages: 52-61
  • DOI: 10.1016/j.physbeh.2018.01.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Higher Incidence of Sleep Disturbance among Survivors with Musculoskeletal Pain after the Great East Japan Earthquake: A Prospective Study (2018)
  • Author(s): Yabe Y, Hagiwara Y, Sekiguchi T, Sugawara Y, Tsuchiya M, Koide M, Itaya N, Yoshida S, Sogi Y, Yano T, Tsuji I, Itoi E.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 244 Issue: 1 Pages: 25-32
  • DOI: 10.1620/tjem.244.25
  • NAID: 130006307431
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between sleep disturbance and new-onset subjective knee pain in Great East Japan Earthquake survivors: A prospective cohort study in the Miyagi prefecture. (2017)
  • Author(s): Hagiwara Y, Sekiguchi T, Sugawara Y, Yabe Y, Koide M, Itaya N, Yoshida S, Sogi Y, Tsuchiya M, Tsuji I, Itoi E.
  • Journal Title: J Orthop Sci. Volume: 23 Issue: 2 Pages: 334-340
  • DOI: 10.1016/j.jos.2017.10.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Excessive Game Playing Is Associated with Poor Toothbrushing Behavior among Athletic Children: A Cross-Sectional Study in Miyagi, Japan (2017)
  • Author(s): Tsuchiya M, Momma H, Sekiguchi T, Kuroki K, Kanazawa K, Watanabe M, Hagiwara Y, Nagatomi R.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 241 Issue: 2 Pages: 131-138
  • DOI: 10.1620/tjem.241.131
  • NAID: 130005332357
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Analgesic Effects of 1st Generation Anti-histamines in Mice (2016)
  • Author(s): Mebae Takahashi, Kazuhiro Shima, Masahiro Tsuchiya, Yoshihiro Hagiwara, Hirokazu Mizoguchi, Shinobu Sakurada, Shunji Sugawara, Takuo Fujita, Takeshi Tadano, Makoto Watanabe, Satoshi Fukumoto, Yasuo Endo
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 4 Pages: 620-624
  • DOI: 10.1248/bpb.b15-00755
  • NAID: 130005141684
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association Between Tooth Loss, Receipt of Dental Care, and Functional Disability in an Elderly Japanese Population: The Tsurugaya Project. (2016)
  • Author(s): T Komiyama, T Ohi, Y Miyoshi, T Murakami, A Tsuboi, Y Tomata, I Tsuji, M Watanabe, Y Hattori.
  • Journal Title: Journal of American Geriatric Society Volume: 64 Issue: 12 Pages: 2495-2502
  • DOI: 10.1111/jgs.14390
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of masticatory activity during unilateral single tooth clenching using muscle functional magnetic resonance imaging. (2016)
  • Author(s): Okada C, Yamaguchi S, Watanabe Y, Watanabe M, Hattori Y.
  • Journal Title: J Oral Rehabil. Volume: 43 Issue: 8 Pages: 583-590
  • DOI: 10.1111/joor.12404
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Contribution of each masticatory muscle to the bite force determined by MRI using a novel metal-free bite force gauge and an index of total muscle activity. (2016)
  • Author(s): Takahashi M, Yamaguchi S, Fujii T, Watanabe M, Hattori Y
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: - Issue: 4 Pages: 804-813
  • DOI: 10.1002/jmri.25223
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 筋機能時における好中球由来IL1βの役割 (2018)
  • Author(s): 土谷 昌広，Chayanit Chaweewannakorn，佐々木 啓一，菅 原 俊二，渡邉 誠，遠藤 康男
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] 長期粉末食飼育がマウスの情動発達に及ぼす影響について (2018)
  • Author(s): 八百板富紀枝，今泉宏紀，川浪啓豪，土谷昌広，只野 武，丹野孝一
  • Organizer: 日本薬学会第138年会
• [Presentation] マウス筋機械痛覚過敏に対するIL-18の関与 (2018)
  • Author(s): 土谷 昌広, 吉田 新一郎, 萩原 嘉廣, 篠田 雅路, 小出 将志, 畠山 裕康, チャウイワンナコン・チャヤニ, 矢野 利尚, 曽木 靖仁, 板谷 信行, 関口 拓矢, 矢部 裕, 土谷 忍, 佐々木 啓一, 神崎 展, 井樋 栄二.
  • Organizer: 第40回日本疼痛学会
• [Presentation] 長期粉末食飼育がマウスの情動発達に及ぼす影響について (2018)
  • Author(s): 八百板 富紀枝, 今泉 宏紀, 川浪 啓豪, 土谷 昌広,只野 武, 丹野 孝一
  • Organizer: 日本薬学会第138年会
• [Presentation] ②長期粉末食飼育誘発性低不安行動におけるグルココルチコイド受容体およびノルアドレナリン神経系の関与 (2017)
  • Author(s): 八百板富紀枝、小澤美芙由、遠藤汐里、土谷昌広、荒井裕一朗、根本亙、中川西修、只野武、丹野孝一
  • Organizer: 日本薬理学会北部会
• [Presentation] 筋機能発現における好中球の産生するIL1βの糖代謝調節機構 (2017)
  • Author(s): 土谷昌広,チャヤニチャウィワンナコン,佐々木啓一,渡部芳彦,渡邉 誠
  • Organizer: 日本補綴歯科学会第126回学術大会
• [Presentation] 東日本大震災被災者における歯周病と不眠症の関連 (2017)
  • Author(s): 土谷昌広，渡邉誠
  • Organizer: 第71回日本口腔科学会学術集会
• [Presentation] 粉末食を用いた長期飼育がマウスの糖代謝機構へ及ぼす影響 (2017)
  • Author(s): 土谷忍、土谷昌広、佐々木啓一、渡邉誠
  • Organizer: 第71回日本口腔科学会学術集会
• [Presentation] 東日本大震災被災者における歯周病と不眠症の関連． (2016)
  • Author(s): 土谷昌広，萩原嘉廣，渡部芳彦，渡邉誠．
  • Organizer: 日本補綴歯科学会第125回学術大会．
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2016-07-08
• [Book] 健康と医療福祉のための栄養学 身体のしくみと栄養素の働きを理解する (2018)
  • Author(s): 渡邉 早苗, 寺本 房子, 松谷 美和子, 土谷 昌広, 小野 若菜子
  • Total Pages: 224
  • Publisher: 医歯薬出版
  • ISBN: 9784263707371