Strategy Foundation of Preemptive medicine for peri-implantitis
| Project/Area Number |
16K11617
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
楠本 哲次 大阪歯科大学, 医療保健学部, 教授 (70186394)
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| Research Collaborator |
YAMAUCHI Nobuhiro
YAMAWAKI Isao
KATO Hirohito
UMEDA Makoto
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | インプラント周囲炎 / hyperglycemia / 硬組織再生 / インプラント / 光線力学療法 / Light Emitting Diode / グルコース濃度 / 炎症 / チタン / 硬組織分化 / 酸化チタン / グルコース / 硬組織分化誘導 / 炎症性サイトカイン / ぺリオドンタルメディシン / ナノ構造 |
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| Outline of Final Research Achievements |
Patients with Diabetes mellitus (DM) have an increased risk of losing their teeth compared with other individuals. Dental implants are a standard of care for treating partial or full edentulism, and various implant surface treatments have recently been developed to increase dental implant stability. However, some studies have reported that DM reduces osseointegration and the success rate of dental implants. The purpose of this study was to determine the effects of high glucose levels for hard tissue formation on a nano-scale modified titanium surface.
High glucose concentration increased hard tissue formation, but the quality of the mineralized tissue decreased. Furthermore, the nano-scale modified titanium surface increased mineralized tissue formation and anti-inflammatory, but the quality of hard tissue was dependent on glucose concentration.
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| Academic Significance and Societal Importance of the Research Achievements |
現在の骨結合型インプラントは初めての症例が行われて約50年が経過している。そのなかで糖尿病を中心とした生活習慣病も今般の食生活の変化に応じて多くの患者が罹患されている。そのような患者がインプラントを過去に埋入されて悪化した症例や，その全身疾患のためにインプラント補綴を受けることができない症例が散見されている。
申請者らはペリオドンタルメディシンの一つで代表的な生活習慣病の糖尿病において硬組織再生治療に及ぼす影響について調べた。その結果，糖尿病患者のインプラント治療のオッセオインテグレーションの獲得がより堅固なものとなり, インプラント治療の適応範囲が拡大されていくのではないかと考えられる。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Hyperglycemia effects hard tissue formation in bone barrow mesenchymal stem cells and periodontal ligament stem cells2017
Author(s)
嘉藤 弘仁, 田口 洋一郎, 山脇 勲, 奥田 麻貴子, 小石 玲子, 野口 正皓, 山内 伸浩, 今井 一貴, 高橋 宰達, 田中 昭男, 梅田 誠
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Journal Title
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)
Volume: 59
Issue: 3
Pages: 118-124
DOI
NAID
ISSN
0385-0110, 1880-408X
Related Report
Peer Reviewed
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[Presentation] Effects of hyperglycaemia in human periodontal ligament stem cells2016
Author(s)
Makoto Umeda, Hirohito Kato, Yoichiro Taguchi, Isao Yamawaki, Nobuhiro Yamauchi, Masahiro Noguchi
Organizer
The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
Place of Presentation
San Diego Convention Center（San Diego, CA, USA）
Year and Date
2016-09-10
Related Report
Int'l Joint Research
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[Presentation] Osteogenic effects of high glucose concentration on nano - modified titanium surface2016
Author(s)
Yoichiro Taguchi, Isao Yamawaki, Satoshi Komasa, Hirohito Kato, Akio Tanaka, Makoto Umeda
Organizer
The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
Place of Presentation
San Diego Convention Center（San Diego, CA, USA）
Year and Date
2016-09-10
Related Report
Int'l Joint Research
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