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Establishment of new adhesive system combined with hard tissue regeneration therapy

Research Project

Project/Area Number 16K11645
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Otake Shiho  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50549946)

Co-Investigator(Kenkyū-buntansha) 野崎 浩佑  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (00507767)
吉田 恵一  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (60240280)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords象牙質 / 接着 / 歯科材料 / 炭酸アパタイト / プライマー / 引張接着強さ / 歯冠修復材料 / 歯科用接着材 / サンドブラスト / マイクロテンサイル / ハイドロキシアパタイト / 炭酸含有アパタイト / ナノ / 表面電荷
Outline of Final Research Achievements

The purpose of this study was to establish new techniques for the creation of biomaterials and surface modification that improve the long-term prognosis of the dental prosthesis for dental caries treatment. We have developed a carbonate ion-containing apatite similar to human dentin. In addition, the surface modification of the composite resin block by sandblasting was recommended to be done immediately before the bonding operation in order to obtain a reliable adhesive strength of the prosthesis. In addition, the composite of Polyetheretherketone and SiO2 was fabricated to enhance adhesive bonding strength between the composite materials and adhesive cements. The adhesive strength increased with a SiO2 content of 40 wt%. These results may suggest the reliable dental treatment methods for dental caries.

Academic Significance and Societal Importance of the Research Achievements

高い審美性や金属アレルギーの心配がないことよりメタルフリー修復が行われてきており複雑な加工,成形が可能となった各種歯科用CAD/CAM材料が歯科において導入されてきている.しかしこれらの材料は化学的にも安定した材料でありその高い安定性により接着については困難な状態であるが,これらの歯科材料を臨床において使用するためには確実な接着が求められる.本研究においてCAD/CAM用レジンブロック,PEEK,新規加圧成形型セラミックスについて更なる有効な接着システム,または表面処理条件を解明した事により,臨床においてより確実な接着操作が可能となり,学術的にも社会的にも有意義な研究成果をあげることとなった.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (24 results)

All 2019 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (16 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Influence of SiO<sub>2</sub> content of polyetheretherketone (PEEK) on flexural properties and tensile bond strength to resin cement2019

    • Author(s)
      Rikitoku S, Otake S, Nozaki K, Yoshida K, Miura H
    • Journal Title

      Dental Materials Journal

      Volume: 38 Issue: 3 Pages: 464-470

    • DOI

      10.4012/dmj.2018-234

    • NAID

      130007657715

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2019-05-29
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of elapsed time after air abrasion on bond strength of luting agent to CAD/CAM resin blocks2019

    • Author(s)
      Asano R, Otake S, Nozaki K, Yoshida K, Miura H.
    • Journal Title

      Journal of Oral Science

      Volume: 61 Issue: 3 Pages: 459-467

    • DOI

      10.2334/josnusd.18-0305

    • NAID

      130007696192

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plate-like hydroxyapatite synthesized from dodecanedioic acid enhances chondrogenic cell proliferation2019

    • Author(s)
      Wint Wit Yee、Horiuchi Naohiro、Nozaki Kosuke、Nagai Akiko、Yamashita Kimihiro、Miyashin Michiyo
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 30 Issue: 4 Pages: 375-386

    • DOI

      10.3233/bme-191060

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Antibacterial Property of Facet-Engineered TiO2 Nanosheet in Presence and Absence of Ultraviolet Irradiation2019

    • Author(s)
      Hayashi Kenichiro、Nozaki Kosuke、Tan Zhenquan、Fujita Kazuhisa、Nemoto Reina、Yamashita Kimihiro、Miura Hiroyuki、Itaka Keiji、Ohara Satoshi
    • Journal Title

      Materials

      Volume: 13 Issue: 1 Pages: 78-78

    • DOI

      10.3390/ma13010078

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An oriented hydroxyapatite film with arrayed plate‐like particles enhance chondrogenic differentiation of ATDC5 cells2019

    • Author(s)
      Komuro Hiroaki、Wint Wit Y.、Horiuchi Naohiro、Nozaki Kosuke、Sasano Tetsuo、Miyashin Michiyo、Yamashita Kimihiro、Nagai Akiko
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 108 Issue: 3 Pages: 537-544

    • DOI

      10.1002/jbm.a.36834

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of controlled micro-/nanosurfaces on osteoblast proliferation2017

    • Author(s)
      Iwata Natsuko、Nozaki Kosuke、Horiuchi Naohiro、Yamashita Kimihiro、Tsutsumi Yusuke、Miura Hiroyuki、Nagai Akiko
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 105 Issue: 9 Pages: 2589-2596

    • DOI

      10.1002/jbm.a.36118

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ag nanoparticle?coated zirconia for antibacterial prosthesis2017

    • Author(s)
      Yamada Risa、Nozaki Kosuke、Horiuchi Naohiro、Yamashita Kimihiro、Nemoto Reina、Miura Hiroyuki、Nagai Akiko
    • Journal Title

      Materials Science and Engineering: C

      Volume: 78 Pages: 1054-1060

    • DOI

      10.1016/j.msec.2017.04.149

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of periodontal ligament-derived cells by type III collagen-coated hydroxyapatite2017

    • Author(s)
      Fujita Kazuhisa、Nozaki Kosuke、Horiuchi Naohiro、Yamashita Kimihiro、Miura Hiroyuki、Nagai Akiko
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 29 Issue: 1 Pages: 15-27

    • DOI

      10.3233/bme-171709

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Bond strengths of cements to a newly developed pressable ceramics.2018

    • Author(s)
      S OTAKE, K HAYASHI, K NOZAKI, W KOMADA, K YOSHIDA and H MIURA.
    • Organizer
      International Association for Dental Research
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bond Strengths of Cements to a New Pressable Ceramics.2017

    • Author(s)
      Hayashi K, Otake S, Omori S, Nemoto R, Asano R, Rikitoku S, Miura H.
    • Organizer
      95th General session & Exhibition of the IADR
    • Place of Presentation
      Moscone West(San Francisco, Calif., USA)
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] III型コラーゲンコートアパタイトによる歯根膜の石灰化制御2017

    • Author(s)
      野崎 浩佑,藤田和久,山下 仁大,三浦 宏之,永井 亜希子
    • Organizer
      第69回日本歯科理工学会学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] III型コラーゲンコートハイドロキシアパタイトによる歯根膜幹細胞挙動の制御2017

    • Author(s)
      藤田和久,野崎浩佑,三浦宏之,永井亜希子
    • Organizer
      日本補綴歯科学会第126回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 埋入部位が吸収性骨補填材の骨形成および吸収性に及ぼす影響2017

    • Author(s)
      野崎浩佑,藤田和久,三浦宏之,永井亜希子
    • Organizer
      日本補綴歯科学会第126回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Electrical and structural evaluation of sodium ion doped beta-tricalcium phosphate2017

    • Author(s)
      Kosuke Nozaki, Takayuki Endo, Naohiro Horiuchi, Kimihiro Yamashita, Kazuaki Hashimoto, Keiji Itaka, Akiko NagaiKosuke Nozaki, Takayuki Endo, Naohiro Horiuchi, Kimihiro Yamashita, Kazuaki Hashimoto, Keiji Itaka, Akiko Nagai
    • Organizer
      The Tenth International Conference on the Science and Technology for Advanced Ceramics (STAC-10)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナトリウムイオン固溶β型リン酸三カルシウムの電気特性と構造評価2017

    • Author(s)
      野崎浩佑,遠藤敬幸,堀内尚紘,山下仁大,橋本和明,位高啓史,永井亜希子
    • Organizer
      第26回無機リン化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Regulation of periodontal ligament-derived cell morphology by type III collagen-coated hydroxyapatite2017

    • Author(s)
      K. Nozaki, K. Fujita, N. Horiuchi, K. Yamashita, H. Miura, A. Nagai, K. Itaka
    • Organizer
      2nd International Symposium on Creation of Life Innovation Materials
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 表面電荷を有するβ型リン酸三カルシウムエレクトレットの構造と特性2017

    • Author(s)
      野崎浩佑,山下仁大 ,永井亜希子
    • Organizer
      日本歯科理工学会平成29年度秋期第70回学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] サンドブラスト処理後の経過時間がCAD/CAM用レジンブロックの接着強さに及ぼす影響について2017

    • Author(s)
      浅野良奈, 大竹志保, 稲垣祐久, 藤田理雅, 大森哲, 三浦宏之
    • Organizer
      日本補綴歯科学会第126 回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 新規PEEK 材に対するレジンセメントの引張接着強さ2017

    • Author(s)
      力徳史朗, 大竹志保, 吉田惠一, 三浦宏之
    • Organizer
      日本補綴歯科学会第126 回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 二ケイ酸リチウムガラスセラミックスの機械的性質について2017

    • Author(s)
      松村茉由子, 駒田亘, 菅野桐子, 林建一郎, 進千春, 大竹志保, 三浦宏之
    • Organizer
      日本補綴歯科学会第126 回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] サンドブラスト処理後の経過時間が CAD/CAM用レジンブロックの接着強さに及ぼす影響について.2016

    • Author(s)
      浅野良奈, 大竹志保, 稲垣祐久, 藤田理雅, 大森哲, 三浦宏之.
    • Organizer
      日本接着歯学会第35回学術大会
    • Place of Presentation
      北海道大学札幌キャンパス学術交流会館(札幌)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
  • [Presentation] In vivo evaluation of the role of carbonate ion in hydroxyapatite for bone remodeling.2016

    • Author(s)
      Kosuke Nozaki, Kazuhisa Fujita, Naohiro Horiuchi, Miho Nakamura, Hiroyuki Miura, Kimihiro Yamashita, Akiko Nagai.
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      Palais des congres de Montreal, Montreal, Canada
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 炭酸イオンにより骨形成と生体吸収速度を調和させたリン酸カルシウムの生体内評価.2016

    • Author(s)
      野崎浩佑,藤田和久,山下仁大,三浦宏之,永井亜希子.
    • Organizer
      公益社団法人日本補綴歯科学会第125回学術大会
    • Place of Presentation
      石川県立音楽堂,ANAクラウンプラザホテル金沢,金沢市,石川県
    • Related Report
      2016 Research-status Report
  • [Presentation] アパタイト多孔体の骨形成 能および吸収性を最適化するための炭酸含有量制御の試み.2016

    • Author(s)
      野崎浩佑,藤田和久,桑村雄太,三浦宏之,山下仁大,橋本和明,永井亜希子.
    • Organizer
      日本バイオマテリアル学会シンポジウム
    • Place of Presentation
      福岡国際会議場,福岡市,福岡県
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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