• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Application of purfied dental pulp stem cells for treatment of osteonecrosis of the jaw

Research Project

Project/Area Number 16K11656
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionKeio University

Principal Investigator

YASUI Takazumi  慶應義塾大学, 医学部(信濃町), 講師(非常勤) (80348771)

Co-Investigator(Kenkyū-buntansha) 中川 種昭  慶應義塾大学, 医学部(信濃町), 教授 (00227745)
森川 暁  慶應義塾大学, 医学部(信濃町), 講師 (00424169)
馬渕 洋  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50424172)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords歯髄幹細胞 / 顎骨壊死 / フローサイトメトリー / 再生医学 / 移植・再生医療
Outline of Final Research Achievements

The purpose of this study was to investigate the efficacy of dental pulp stem cell transplantation for the prevention and treatment of bisphosphonate-related osteonecrosis of the jaw. We previously identified isolation markers of human dental pulp stem cells and reported that purified dental pulp stem cells by flow cytometry show high proliferation and osteogenic potential. In the present study, it was suggested that transplantation of purified dental pulp stem cells into immunodeficient mice after taking bisphosphonate and tooth extraction has the ability to prevent osteonecrosis of the jaw.

Academic Significance and Societal Importance of the Research Achievements

ビスフォスフォネート製剤等の骨吸収抑制薬により顎骨壊死を生じることが報告されている。抜歯が発症リスク因子とされ、骨吸収抑制薬投与前の抜歯と口腔ケアが重要と考えられているが、実際には投与後に抜歯を必要とする機会は少なくなく、顎骨壊死予防の有効な手段の確立が望まれる。また、顎骨壊死を生じた際には外科的に顎骨切除を行うことがあり、切除部の再生療法の開発が望まれる。本研究では、予期的に分離したLNGFR(Low+)THY-1(High+)DPSCをビスフォスフォネート関連顎骨壊死(BRONJ)モデルマウスに移植し、抜歯後の顎骨壊死予防への有効性を評価した。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Isolation of dental pulp stem cells with high osteogenic potential2017

    • Author(s)
      Yasui Takazumi、Mabuchi Yo、Morikawa Satoru、Onizawa Katsuhiro、Akazawa Chihiro、Nakagawa Taneaki、Okano Hideyuki、Matsuzaki Yumi
    • Journal Title

      Inflammation and Regeneration

      Volume: 37 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s41232-017-0039-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 高い治療効果を有する歯髄幹細胞の分離をめざして2017

    • Author(s)
      安居孝純
    • Organizer
      第38回日本炎症・再生医学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 純化歯髄幹細胞は高い骨形成能を有する2016

    • Author(s)
      安居孝純, 馬渕 洋, 森川 暁, 鬼澤勝弘, 赤澤智宏, 中川種昭, 岡野栄之, 松崎有未
    • Organizer
      第37回日本炎症・再生医学会
    • Place of Presentation
      京都市勧業会館みやこめっせ(京都府京都市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi