The influence of change of sympathetic nerve activities against the treatment response, muscle pathology and muscle activities in patients with chronic masticatory muscle disorders.

• Project/Area Number: 16K11669
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SATO Jun 北海道大学, 歯学研究院, 講師 (60319069)
• Co-Investigator(Kenkyū-buntansha): 北川 善政 北海道大学, 歯学研究院, 教授 (00224957) ; 大賀 則孝 北海道大学, 歯学研究院, 助教 (40548202)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 自律神経 / 交感神経 / 副交感神経 / 口腔顎顔面痛 / 咀嚼筋 / 副交換神経 / 慢性疼痛 / 舌痛症 / 筋病理 / 唾液

Outline of Final Research Achievements

We included the 13 cases with chronic orofacial pain (OFP group) and 37 cases without OFP (control group)in this study. The gender of the subject was male in 31 cases, and female in 19 cases, respectively. The age of the subjects ranged from 21 to 78 years (mean: 46 years). We examined their sympathetic activity using heart beat fluctuation. We examined their low frequency (LF) factor and high frequency (HF) factor. The HF means sympathetic nerve activity and the LF/HF means the parasympathetic nerve. The HF ranged 4.3-986.2 (mean: 227.3) and the LF/HF ranged 0.4-22.7 (mean: 4.1). The HF was significantly higher in the OFP group than that of the control group (P < 0.01). On the other hand, there were no significant differences of the heart rate(P = 0.92) and LF/HF (P = 0.26) between the two groups.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は慢性の口腔顔面痛を伴う患者さんは慢性疼痛を伴わない人と比較して有意に副交感神経活動が低下していることを示すものである。一方で慢性疼痛患者群とコントロ－ル群では交感神経自体の活性に有意差は認められなかった。この結果は研究開始前の慢性疼痛患者さんでは交感神経活動が直接有意に亢進しているという仮説を覆すものである。むしろ慢性疼痛患者さんではリラックス時に活動が活性化する副交感神経活動自体が低下している可能性を示すものである。慢性疼痛患者さんに対する治療の直接のタ－ゲットは交感神経活動の抑制よりもむしろ、副交感神経活性の賦活化を優先する方がふさわしい可能性を示したものと思われる。

Research Products

• [Journal Article] Imaging modalities for drug-related osteonecrosis of the jaw (3), Positron emission tomography imaging for the diagnosis of medication-related osteonecrosis of the jaw. (2019)
  • Author(s): Kitagawa Y, Ohga N, Asaka T, Sato J, Hata H, Helman J, Tsuboi K, Amizuka N, Kuge Y, Shiga T
  • Journal Title: Jpn Dent Sci Rev Volume: 55 Issue: 1 Pages: 65-70
  • DOI: 10.1016/j.jdsr.2018.12.001
  • NAID: 50014414221
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypoxic volume evaluated by 18F-fluoromisonidazole positron emission tomography (FMISO-PET) may be a prognostic factor in patients with oral squamous cell carcinoma: preliminary analyses. (2018)
  • Author(s): Sato J, Kitagawa Y, Watanabe S, Asaka T, Ohga N, Hirata K, Shiga T, Satoh A, Tamaki N.
  • Journal Title: Int J Oral Maxillofac Surg Volume: 47(5) Issue: 5 Pages: 553-560
  • DOI: 10.1016/j.ijom.2017.09.007
  • Peer Reviewed / Open Access
• [Journal Article] The direct immunofluorescence using non-lesional buccal mucosa in mucous membrane pemphigoid. (2018)
  • Author(s): Kamaguchi M, Iwata H, Ujiie I, Ujiie H, Sato J, Kitagawa Y, Shimizu H.
  • Journal Title: Frontier in Med Volume: 5
  • DOI: 10.3389/fmed.2018.00020
  • NAID: 120006416018
  • Peer Reviewed
• [Journal Article] Clinical possibility of baseline FDG-PET SUVmax as a prognostic factor in patients with head and neck non-Hodgkin's lymphoma: a preliminary study. (2018)
  • Author(s): Yoshikawa K, Onodera-Kyan M, Kitagawa Y, Satoh A, Sato J, Kitamura T, Shiga T, Watanabe S.
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine and Pathology (JOMSMP) Volume: 30 Issue: 4 Pages: 319-323
  • DOI: 10.1016/j.ajoms.2018.02.012
  • Peer Reviewed
• [Journal Article] Clinical possibility of baseline FDG-PET SUVmax as a prognostic factor in patients with head and neck non-Hodgkin's lymphoma: a preliminary study (2018)
  • Author(s): Yoshikawa K, Onodera-Kyan M, Kitagawa Y, Satoh A, Sato J, Kitamura T, Shiga T, Watanabe S.
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine and Pathology Volume: in-press
  • Peer Reviewed
• [Journal Article] Possible cases of dental treatment-associated death under local anesthesia in Japan: a review of the literature (2017)
  • Author(s): Miyakoshi M, Sato J, Wada M, Yoshikawa K, Murata T, Taishi Y, Kitamori S, Kitagawa Y.
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 29 Pages: 289-294
  • Peer Reviewed
• [Journal Article] 18F-Fluoromisonidazole positron emission tomography (FMISO-PET) may reflect hypoxia and cell proliferation activity in oral squamous cell carcinoma (2017)
  • Author(s): Sato J, Kitagawa Y, Watanabe S, Asaka T, Ohga N, Hirata K, Okamoto S, Shiga T, Shindoh M, Kuge Y, Tamaki N.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 124 Pages: 261-270
  • Peer Reviewed
• [Journal Article] Elimination of oral candidiasis may increase stimulated whole salivary flow rate. (2016)
  • Author(s): Ohga N＊, Yamazaki Y, Sato J, Asaka T, Morimoto M, Hata H, Satoh C, Kitagawa Y
  • Journal Title: Arch Oral Biol Volume: 71 Pages: 129-133
  • DOI: 10.1016/j.archoralbio.2016.06.028
  • Peer Reviewed / Open Access
• [Journal Article] Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study. (2016)
  • Author(s): Asaka T, Ohga N, Yamazaki Y, Sato J, Satoh C, Kitagawa Y
  • Journal Title: Clin Oral Investig Volume: epub Issue: 7 Pages: 1-8
  • DOI: 10.1007/s00784-016-2004-z
  • Peer Reviewed / Open Access
• [Presentation] Current international consensus on burning mouth syndrome: the diagnosis, classifications and pathophysiology. (2018)
  • Author(s): Sato J, Kitagawa Y
  • Organizer: 第31会日本顎関節学会・第23回日本口腔顔面痛学会
• [Presentation] Review of current international consensus on burning mouth syndrome: Treatment options (2018)
  • Author(s): Sato J, Kitagawa Y, Asaka T, Ohga N, Tsuchiya E,Yamashita E, Satoh C
  • Organizer: 14th Biennial Congress of the European Association of Oral Medicine in conjunction with the World Workshop on Oral Medicien
  • Int'l Joint Research
• [Presentation] Close relationship between the palmoplantar pustulosis and dental treatment (2018)
  • Author(s): Asaka T, Morimoto M, Sato J, Ohga N, Kitagawa Y
  • Organizer: 14th Biennial Congress of the European Association of Oral Medicine in conjunction with the World Workshop on Oral Medicien
  • Int'l Joint Research
• [Presentation] 「Medically unexplained oral symptom への口腔内科的アオウロ－チ」 当科における「MUS患者さん」の対応：第二弾、およびBurning Mouth Syndrome と「MUS」 (2017)
  • Author(s): 佐藤 淳、浅香卓哉、大賀則孝、
  • Organizer: 第27回日本口腔内科・第30回日本口腔診断学会:
  • Invited
• [Presentation] 北大歯科における核医学を用いた臨床研究 (2017)
  • Author(s): 佐藤 淳
  • Organizer: 日本核医学会 中国・四国地方会
  • Invited
• [Presentation] Relationships between FMISO- and FDG-PET parameters including hypoxic volume of the tumor and prognosis in patients with oral squamous cell carcinoma after surgery (2016)
  • Author(s): Sato, J, Kitagawa, Y, Watanabe, S, Kenji H, Okamoto, S, Noritaka, O, Asaka, T, Miyakoshi, M, Hata, H, Shiga T, Shindoh M, Tamaki N
  • Organizer: Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: バルセロナ・コンベンションセンタ－、スペイン,
  • Year and Date: 2016-10-18
  • Int'l Joint Research
• [Presentation] 合同シンポジウム1 （日本歯科心身医学会協力企画：「Medically unexplained oral symptom への口腔内科的アオウロ－チ」: 当科における「Medically unexplained oral symptom」患者への対応 (2016)
  • Author(s): 佐藤 淳、浅香卓哉、大賀則孝、佐藤千晴、佐藤 明、北川善政
  • Organizer: 第26回日本口腔内科・第29回日本口腔診断学会
  • Place of Presentation: 岡山県、岡山市・さん太ホ－ル
  • Year and Date: 2016-09-22
  • Invited
• [Book] Oral Science in Japan 2017 (2017)
  • Author(s): Morimoto M, Ohga N, Kashima H, Asaka T, Satoh C, Sato J, Kitagawa Y
  • Total Pages: 84
  • Publisher: JAPANESE STOMATOLOGICAL SOCIETY
  • ISBN: 9784990823733