Neural basis for increases in TMJ nociception under stress conditions
| Project/Area Number |
16K11679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
黒瀬 雅之 新潟大学, 医歯学系, 助教 (40397162)
山村 健介 新潟大学, 医歯学系, 教授 (90272822)
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| Research Collaborator |
Takagi Ritsuo
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔顔面痛 / ストレス / 咬筋 / ラット / 三叉神経 / 三叉神経脊髄路核尾側亜核 / 侵害応答 / うつ / 痛み / 強制水泳ストレス / 神経科学 / 情動 / 電気生理 / 侵害受容 / ウツ / 顎関節 |
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| Outline of Final Research Achievements |
Psychological stress can increase orofacial nociception. We determined the basis for enhancement of orofacial nociception in the trigeminal subnucleus caudalis (Vc) under repeated stress conditions using the rat model. Repeated forced swim stress had facilitatory effects on nociceptive neural responses in the Vc region, suggesting that increases in orofacial pain responses could be due to the enhancement of neural excitability in the Vc region. we determined the effects of repeated administration of selective serotonin -reuptake inhibitor (SSRI) on nociceptive neural activities in the Vc region in response to MM injury with formalin. Results revealed that SSRI could significantly inhibited enhanced neural activities in the Vc region under stress conditions. These results indicated that dysfunction of serotonergic mechanisms could contribute to the increases in masseter muscle nociception after repeated psychophysical stress conditions.
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| Academic Significance and Societal Importance of the Research Achievements |
ストレスが持続するとしばしば痛みが発生したり、増大したりする。一方、人が社会生活を営む上で心理ストレスは不可避である。本研究はストレスが痛みを増大させる事実を歯科的な痛みモデルで示した上で、抗うつ薬として広く使われている、セロトニン再取り込み阻害剤の投与が、ストレスによる痛みを軽減させることを明らかにした。つまりストレス制御こそが痛みのコントロールに重要であり、ストレスによる脳内セロトニン機構の変調の改善が、痛みの軽減に重要であることを示すものである。ストレスが日常的な存在である以上、生活習慣の中でセロトニン機構を調整することが 生活の質を向上させる上で重要になる。
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Report
(4 results)
Research Products
(38 results)
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[Presentation] Psychophysical Stress Enhances Orofacial Nociception in the Rostral Ventromedial Medulla2018
Author(s)
"Shiho Shimizu, Yosuke Nakatani, Masayuki Kurose, Mana Hasegawa, Nobuyuki Ikeda, Noritaka Fujii, Ritsuo Takagi, Kensuke Yamamura, Keiichiro Okamoto, "
Organizer
IADR2018, London
Related Report
Int'l Joint Research
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[Presentation] Japanese Rice Wine, Sake, inhibits Stress-Induced Jaw Muscle Nociception2018
Author(s)
Keiichiro Okamoto, Yosuke Nakatani, Shiho Shimizu, Masayuki Kurose, Yoshito Kakihara, Makio Saeki, Ritsuo Takagi, Kensuke Yamamura
Organizer
IADR2018, London
Related Report
Int'l Joint Research
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