| Project/Area Number |
16K11697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Tojyo Itaru 和歌山県立医科大学, 医学部, 講師 (70405439)
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| Co-Investigator(Kenkyū-buntansha) |
平石 幸裕 和歌山県立医科大学, 医学部, 博士研究員 (40573449)
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| Research Collaborator |
Nakanishi Takashi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔扁平上皮癌 / PD-L1 / p53 / CK17 / 免疫チェックポイント阻害剤 / 免疫チェックポイント阻害薬 / PD-1 / 免疫染色 / 細胞培養 / がん免疫療法 |
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| Outline of Final Research Achievements |
We studied the correlation among immunohistochemical expressions of p53, CK17, PD-L1 in 48 biopsy samples of oral squamous cell carcinoma. Positive rate of p53, CK17, PD-L1(tumor cells) and PD-L1(infiltrating lymphocytes in tumor) is 63.2%, 91.7%, 48.9% and 57.1% respectively. Regarding tumor cells The expression of PD-L1 and p53 positively correlated. Because resolution time of variant p53 protein delays and the protein is accumulated into a nucleus, the variant p53 protein is identified as overexpression. Although p53 inhibits the expression of PD-L1 directly, when variant p53 which lost a function is accumulated, PD-L1 overexpresses. Thus, it is thought that the expression of p53 and PD-L1 shows positively correlation in oral squamous cell carcinoma.
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| Academic Significance and Societal Importance of the Research Achievements |
学術的には口腔扁平上皮癌において、p53の発現がPD-L1の発現に正の相関を示すことは、これまで報告されたことはなく、新知見である。社会的にはPD-L1の口腔扁平上皮癌組織における発現は、ニボルマブが口腔扁平上皮癌に奏功するかどうかのバイオマーカーの一つと考えられており、口腔扁平上皮癌においてp53がPD-L1の発現に正の相関を示すことが確認されれば、口腔扁平上皮癌組織におけるp53の発現もニボルマブが患者に奏功するかどうかのバイオマーカーの一つとして考えられる可能性がある。
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