Analysis by the genetic and environmental approaches for the elucidation of masticatory muscle tendon-aponeurosis hyperplasia
| Project/Area Number |
16K11699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University (2018-2020)
Saitama Medical University (2016-2017) |
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Principal Investigator |
Yoda Tetsuya 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (60242210)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 毅 埼玉医科大学, 医学部, 准教授 (60406494)
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| Project Period (FY) |
2016-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 咀嚼筋 / 腱 / 腱膜 / メカニカルストレス / 遺伝的要因 / 遺伝子 / 顎関節 / 咀嚼筋腱・腱膜過形成症 / yes-associated protein / CRYBA4 / エストロゲン / Scleraxis / Tenomodulin / 腱分化 / 遺伝子解析 |
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| Outline of Final Research Achievements |
Oestrogen and Cryba4 may be associated with the progression of masticatory muscle tendon-aponeurosis hyperplasia (MMTAH). Cyclic stretch induces decorin expression via yes-associated protein in tenocytes and decorin is upregulated in tendons of MMTAH, suggesting that tendons of MMTAH were subjected to cyclic stretch conditions. Comprehensive gene expression analysis revealed upregulated molecules which is related with mechanical stress or slow muscle. Moreover, we found that cyclic stretch upregulated specific genes in tendons of masticatory muscle but not Achilles tendons. These specific molecules may be associated with the onset of MMTAH.
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| Academic Significance and Societal Importance of the Research Achievements |
咀嚼筋腱・腱膜過形成症の病態は遺伝的要因と環境的要因であると考えられていたが、科学的根拠は全くなかった。本研究の遂行により、メカニカルストレス、特に反復性伸展刺激が腱細胞に対して特異的分子を誘導することがわかり、そのメカニズムの一部が明らかになった。以上は環境的要因の解明に役立つこととなった。また、遺伝的要因の解明として病態に関わる分子群の同定につながった。メカニカルストレスに関わる分子の解析により、整形外科における腱疾患の病態の解明にも役立つことと思われ、社会的にも大きな意義をもつ研究であった。
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Report
(6 results)
Research Products
(7 results)
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[Journal Article] Possible association of oestrogen and Cryba4 with masticatory muscle tendon-aponeurosis hyperplasia2018
Author(s)
Naoki Hayashi, Tsuyoshi Sato, Shoichiro Kokabu, Michihiko Usui, Megumi Yumoto, Eiji Ikami, Yasushi Sakamoto, Akira Nifuji, Tadayoshi Hayata, Masaki Noda, Tetsuya Yoda
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Journal Title
Oral Diseases
Volume: 印刷中
Related Report
Peer Reviewed / Int'l Joint Research
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