| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Metastasis is the most important prognostic factor for oral cancer. However, it has not yet been developed an effective treatment to overcome metastasis. This is considered to be due to the fact that the conventional focus point can not target the rate-limiting step of metastatic foci formation. In this study, I examined methods to release the resistance to the cell death signal acquired by metastatic cells and activate the ability of the body to induce cancer cell death.
As a result, it has been suggested that Src inactivation on intravascular cancer cells can dissolve its resistance to TRAIL (death ligand to cancer cells) and suppress the formation of metastatic foci.
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