Mechanism of acquired resistance and genome evolution treated with anti-cancer drug against oral cancer
| Project/Area Number |
16K11737
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山根木 康嗣 兵庫医科大学, 医学部, 講師 (00434944)
川邊 睦記 兵庫医科大学, 医学部, 助教 (10760720)
岸本 裕充 兵庫医科大学, 医学部, 教授 (30291818)
中野 芳朗 兵庫医科大学, 医学部, 教授 (30360267)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔がん / 唾液腺癌 / 癌化学療法 / 放射線治療 / 獲得耐性 / 口腔扁平上皮癌 / ゲノム変化 / 口腔癌 / 治療抵抗性 / 遺伝子変異 / がん化学療法 / 遺伝子変化 / 自然耐性 / ゲノム解析 / 次世代シークエンサー |
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| Outline of Final Research Achievements |
In this study, we established newly oral squamous cell carcinoma cell lines and salivary gland carcinoma cell line derived from surgical specimen. Moreover, we analyzed some oncogene and tumor suppressor gene. Furthermore, we established acquired resistant cell lines against CDDP and Cmab. In addition, we established radiation resistant oral carcinoma cell line. Now, we analyzed mutation of oncogene and tumor suppressor gene using Next Generation Sequencer against parental cell lines. Next, we established mucoepidermoid carcinoma cell lines, and adenoid cystic carcinoma cell line. we will analyze molecular characterization of salivary gland carcinoma cell lines.
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| Academic Significance and Societal Importance of the Research Achievements |
口腔がんの治療方針としては外科切除が優先されるが、術後再発や転移のリスクが高い場合は放射線化学療法（あるいは放射線治療）が行われることが推奨される。術後治療の効果が患者の予後を決定するといっても過言ではない。われわれは術後治療の効果判定を切除した組織検体から予測できないかと考え、患者由来の癌培養細胞を作成し、がん化学療法や放射線治療を行った際の遺伝子の変化から効果予測が可能かを検討した。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching.2019
Author(s)
Otsuru M, Ota Y, Yanamoto S, Okura M, Umeda M, Kirita T, Kurita H, Ueda M, Komori T, Yamakawa N, Kamata T, Hasegawa T, Shibahara T, Ohiro Y, Yamashita Y, Noguchi K, Noguchi T, Karakida K, Naito H, Aikawa T, Yamashita T, Kabata D, Shintani A.
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Journal Title
Ann Surg Oncol.
Volume: 26
Issue: 2
Pages: 555-563
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Assessment of tumor response to chemoradiotherapy and predicting prognosis in patients with head and neck squamous cell carcinoma by PERCIST2018
Author(s)
Katsuura K, Kitashima K,Fujiwara M, Tarada T, Uwa N, Noguch K, Doi H, Tamaki Y, Yoshida R, Tsuchitani T, Fujita M, Yamakado K
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Journal Title
Annals of Nuclear Medicine
Volume: 32(7)
Issue: 7
Pages: 453-62
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Change in tongue pressure in patients with head and neck cancer after surgical resection2017
Author(s)
Hasegawa Y, Sugahara K, Fukuoka T, Saito S, Sakuramoto A, Horii N, Sano S, Hasegawa , Nakao Y, Nanto T, Kadoi K, Moridera K, Noguchi K, Domen K, Kishimoto H.
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Journal Title
Odontology
Volume: 00
Issue: 4
Pages: 00-00
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Hedgehog signaling and genetic diseases.2016
Author(s)
Yoshiro Nakano, Kazuma Noguchi, Hideaki Chiyo, Ritsuko Pooh, Hiromitsu Kishimoto, Tomoko Hashimoto-Tamaoki
Organizer
The 13th International Congress of Human Genetics
Place of Presentation
国立京都国際会議場（京都府京都市）
Year and Date
2016-04-06
Related Report
Int'l Joint Research
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