| Project/Area Number |
16K11748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
丹羽 均 大阪大学, 歯学研究科, 教授 (30218250)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経障害性疼痛 / 炎症性疼痛 / 低酸素負荷 / 筋性疼痛 / c-Fos / 眼窩下神経 / Von Frey / 神経栄養因子 / 三叉神経 |
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| Outline of Final Research Achievements |
This study tested several pain models and compared the development of behavioral responses to pain and sensory stimulation. The models included infra-orbital nerve chronic constriction and crush injury models, masseter muscle pain model, and chronic hypoxia-induced dysesthesia model. In nerve-injury and muscle pain models, the mechanical and thermal thresholds were found to decrease after an experimental intervention but the time course changes differed between the two models. In dysesthesia mode, sensory thresholds of the oral mucosa were decreased while the mechanical thresholds of whisker pad skin were not altered. Chronic hypoxia-induced dysesthesia model were found to show an increase of c-Fos-positive cells in the trigeminal spinal subnucleus caudalis.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究成果から、疼痛反応の発現過程やその時間経過が異なる疼痛モデルと神経障害性疼痛モデルとを比較することによって、今後、神経系の再生に関わる重要な神経栄養因子が、疼痛制御や抑制に関わる神経成長因子の役割を明らかにする研究につなげていくことに社会的意義がある。
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